Xiaflex and Accidental death - a phase IV clinical study of FDA data

Summary:

Accidental death is reported only by a few people who take Xiaflex.

The phase IV clinical study is created by eHealthMe based on reports of 4,355 people who have side effects while taking Xiaflex from the FDA, and is updated regularly.

Phase IV trials are used to detect adverse drug outcomes and monitor drug effectiveness in the real world. With medical big data and AI algorithms, eHealthMe is running millions of phase IV trials and makes the results available to the public. Our original studies have been referenced on 600+ medical publications including The Lancet, Mayo Clinic Proceedings, and Nature.



On Sep, 26, 2022

4,355 people reported to have side effects when taking Xiaflex.
Among them, 2 people (0.05%) died.


What is Xiaflex?

Xiaflex has active ingredients of collagenase clostridium histolyticum. eHealthMe is studying from 4,357 Xiaflex users for its effectiveness, alternative drugs and more.

Number of Xiaflex and Accidental death reports submitted per year:

Could Xiaflex cause Accidental death?

Time on Xiaflex when people died *:

  • < 1 month: 100 %
  • 1 - 6 months: 0.0 %
  • 6 - 12 months: 0.0 %
  • 1 - 2 years: 0.0 %
  • 2 - 5 years: 0.0 %
  • 5 - 10 years: 0.0 %
  • 10+ years: 0.0 %

Gender of people who died when taking Xiaflex *:

  • female: 0.0 %
  • male: 100 %

Age of people who died when taking Xiaflex *:

  • 0-1: 0.0 %
  • 2-9: 0.0 %
  • 10-19: 0.0 %
  • 20-29: 0.0 %
  • 30-39: 0.0 %
  • 40-49: 0.0 %
  • 50-59: 0.0 %
  • 60+: 100 %

Common drugs people take besides Xiaflex *:

  1. Zocor: 2 people, 100.00%
  2. Ibuprofen: 2 people, 100.00%
  3. Aspirin: 2 people, 100.00%

Common side effects people have before they died *:

  1. Oedema Peripheral (superficial swelling): 2 people, 100.00%
  2. Head Injury: 2 people, 100.00%
  3. Traumatic Brain Injury (brain injury due to trauma): 1 person, 50.00%
  4. Road Traffic Accident: 1 person, 50.00%
  5. Multiple Injuries: 1 person, 50.00%
  6. Brain Stem Syndrome: 1 person, 50.00%

Common conditions people have *:

  1. Dupuytren's Contracture (thickening of the fibrous tissue layer underneath the skin of the palm and fingers): 2 people, 100.00%

* Approximation only. Some reports may have incomplete information.


How to use the study?

You can discuss the study with your doctor, to ensure that all drug risks and benefits are fully discussed and understood.



Related studies

Expand to all the drugs that have ingredients of collagenase clostridium histolyticum:

Alternative drugs to, pros and cons of Xiaflex:

Common Xiaflex side effects:

Browse all side effects of Xiaflex:

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COVID vaccines that are related to Accidental death:

Common drugs associated with Accidental death:

All the drugs that are associated with Accidental death:

All the conditions that are associated with Accidental death:

How the study uses the data?

The study uses data from the FDA. It is based on collagenase clostridium histolyticum (the active ingredients of Xiaflex) and Xiaflex (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

Who is eHealthMe?

With medical big data and proven AI algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 600+ medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.

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