Xiaflex and Injection site bruising - a phase IV clinical study of FDA data
Summary:
Injection site bruising is found among people who take Xiaflex, especially for people who are male, 60+ old, have been taking the drug for < 1 month.
The phase IV clinical study analyzes which people take Xiaflex and have Injection site bruising. It is created by eHealthMe based on reports of 4,355 people who have side effects when taking Xiaflex from the FDA, and is updated regularly. You can use the study as a second opinion to make health care decisions.
Phase IV trials are used to detect adverse drug outcomes and monitor drug effectiveness in the real world. With medical big data and AI algorithms, eHealthMe is running millions of phase IV trials and makes the results available to the public. Our original studies have been referenced on 600+ medical publications including The Lancet, Mayo Clinic Proceedings, and Nature.
4,355 people reported to have side effects when taking Xiaflex.
Among them, 181 people (4.16%) have Injection site bruising.
What is Xiaflex?
Xiaflex has active ingredients of collagenase clostridium histolyticum. eHealthMe is studying from 3,704 Xiaflex users for its effectiveness, alternative drugs and more.
What is Injection site bruising?
Injection site bruising is found to be associated with 1,484 drugs and 947 conditions by eHealthMe.
Number of Xiaflex and Injection site bruising reports submitted per year:

Time on Xiaflex when people have Injection site bruising *:
Gender of people who have Injection site bruising when taking Xiaflex*:
Age of people who have Injection site bruising when taking Xiaflex *:
Common drugs people take besides Xiaflex *:
Common side effects people have besides Injection site bruising *:
Common conditions people have *:
* Approximation only. Some reports may have incomplete information.
Do you take Xiaflex and have Injection site bruising?
Check whether Injection site bruising is associated with a drug or a conditionHow to use the study?
You can discuss the study with your doctor, to ensure that all drug risks and benefits are fully discussed and understood.
Related studies
How severe was Injection site bruising and when was it recovered:
Expand to all the drugs that have ingredients of collagenase clostridium histolyticum:
Alternative drugs to, pros and cons of Xiaflex:
- Xiaflex (3,704 reports)
Common Xiaflex side effects:
- Curvature of the penis: 125 reports
- Cuts and puncture wounds: 116 reports
- Drug ineffective: 899 reports
- Dupuytren's contracture (thickening of the fibrous tissue layer underneath the skin of the palm and fingers): 137 reports
- Fracture of penis (rupture of one or both of covering): 362 reports
- Head injury: 453 reports
- Injection site bruising: 181 reports
- Injection site pain: 293 reports
- Injection site swelling: 190 reports
- Pain: 280 reports
- Pain in extremity: 154 reports
- Penile haematoma (localized collection of blood outside the blood vessels on penis): 183 reports
- Penile pain: 285 reports
- Penile swelling: 394 reports
- Peripheral swelling: 123 reports
- Swelling: 324 reports
Browse all side effects of Xiaflex:
a b c d e f g h i j k l m n o p q r s t u v w x y zInjection site bruising treatments and more:
- Injection site bruising (59,700 reports)
COVID vaccines that are related to Injection site bruising:
- Injection site bruising in Moderna COVID Vaccine
- Injection site bruising in Pfizer BioNTech Covid Vaccine
- Injection site bruising in Johnson and Johnson Covid Vaccine
Common drugs associated with Injection site bruising:
- Acetylsalicylic acid: 144 reports
- Actemra: 318 reports
- Acth: 156 reports
- Acthar: 156 reports
- Actos: 323 reports
- Advair hfa: 272 reports
- Advil: 190 reports
- Aimovig: 480 reports
- Albuterol: 259 reports
- Alendronate sodium: 128 reports
- Aleve: 146 reports
- Allegra: 167 reports
- Allopurinol: 143 reports
- Alprazolam: 186 reports
- Amaryl: 263 reports
- Ambien: 275 reports
- Amlodipine: 634 reports
- Ampyra: 194 reports
- Apokyn: 119 reports
- Arava: 295 reports
- Asa: 181 reports
- Asacol: 168 reports
- Aspirin: 2,009 reports
- Atenolol: 393 reports
- Ativan: 152 reports
- Avandia: 249 reports
- Avonex: 1,902 reports
- Baby aspirin: 277 reports
- Baclofen: 269 reports
- Basaglar: 212 reports
- Benadryl: 235 reports
- Benlysta: 172 reports
- Betaseron: 499 reports
- Biotin: 161 reports
- Botox: 358 reports
- Botox cosmetic: 190 reports
- Budesonide: 105 reports
- Bydureon: 873 reports
- Byetta: 2,047 reports
- Calcium: 932 reports
- Carvedilol: 172 reports
- Celebrex: 456 reports
- Celexa: 160 reports
- Centrum: 130 reports
- Cimzia: 446 reports
- Claritin: 155 reports
- Clonazepam: 292 reports
- Clopidogrel: 112 reports
- Copaxone: 725 reports
- Cosentyx: 1,698 reports
- Coumadin: 403 reports
- Crestor: 326 reports
- Cymbalta: 365 reports
- Dexilant: 103 reports
- Diazepam: 110 reports
- Diovan: 162 reports
- Dupixent: 580 reports
- Effexor: 181 reports
- Eliquis: 125 reports
- Enbrel: 14,029 reports
- Enoxaparin sodium: 216 reports
- Epipen: 148 reports
- Evista: 129 reports
- Extavia: 232 reports
- Fenofibrate: 119 reports
- Fish oil: 546 reports
- Flexeril: 183 reports
- Flonase: 218 reports
- Flovent: 139 reports
- Fluoxetine: 160 reports
- Folic acid: 822 reports
- Forteo: 5,006 reports
- Fosamax: 208 reports
- Furosemide: 371 reports
- Gabapentin: 736 reports
- Genotropin: 328 reports
- Glatopa: 374 reports
- Glimepiride: 233 reports
- Glipizide: 360 reports
- Glucophage: 403 reports
- Glyburide: 250 reports
- Hctz: 138 reports
- Humalog: 923 reports
- Humatrope: 142 reports
- Humira: 10,066 reports
- Humulin n: 137 reports
- Humulin r: 133 reports
- Hydrochlorothiazide: 408 reports
- Hydroxyzine: 107 reports
- Ibu: 723 reports
- Ibuprofen: 646 reports
- Imitrex: 114 reports
- Imuran: 186 reports
- Insulin: 232 reports
- Januvia: 156 reports
- Kineret: 191 reports
- Klonopin: 208 reports
- Lantus: 1,269 reports
- Lantus solostar: 506 reports
- Lasix: 317 reports
- Leflunomide: 283 reports
- Levemir: 122 reports
- Levothyroxine sodium: 152 reports
- Lexapro: 302 reports
- Lialda: 128 reports
- Lipitor: 514 reports
- Lisinopril: 934 reports
- Lopurin: 143 reports
- Lorazepam: 207 reports
- Losartan: 344 reports
- Lovenox: 309 reports
- Lyrica: 326 reports
- Magnesium: 309 reports
- Makena: 285 reports
- Melatonin: 106 reports
- Meloxicam: 295 reports
- Metformin: 2,195 reports
- Methotrexate: 3,661 reports
- Methotrexate sodium: 205 reports
- Metoprolol tartrate: 111 reports
- Mobic: 111 reports
- Morphine: 193 reports
- Multivitamin: 594 reports
- Naproxen: 219 reports
- Nasonex: 108 reports
- Neurontin: 249 reports
- Nexium: 456 reports
- Norco: 131 reports
- Norvasc: 232 reports
- Novolog: 322 reports
- Omeprazole: 847 reports
- Omnitrope: 283 reports
- Orencia: 351 reports
- Oxycodone: 223 reports
- Pantoprazole: 370 reports
- Paxil: 121 reports
- Pegasys: 398 reports
- Pentasa: 150 reports
- Percocet: 176 reports
- Plaquenil: 642 reports
- Plavix: 602 reports
- Plegridy: 270 reports
- Potassium: 219 reports
- Praluent: 679 reports
- Prednisone: 2,505 reports
- Premarin: 150 reports
- Prevacid: 197 reports
- Prilosec: 354 reports
- Probiotic: 104 reports
- Profen: 646 reports
- Prolia: 128 reports
- Protonix: 219 reports
- Prozac: 203 reports
- Q10: 102 reports
- Ramipril: 146 reports
- Ranitidine: 203 reports
- Rebif: 961 reports
- Remicade: 145 reports
- Repatha: 4,345 reports
- Ribavirin: 247 reports
- Rituxan: 117 reports
- Sandostatin: 423 reports
- Sandostatin lar: 340 reports
- Sertraline: 159 reports
- Simponi: 167 reports
- Simvastatin: 381 reports
- Singulair: 502 reports
- Spiriva: 215 reports
- Spironolactone: 176 reports
- Strensiq: 246 reports
- Sulfasalazine: 341 reports
- Sumavel dosepro: 197 reports
- Symbicort: 297 reports
- Symlin: 111 reports
- Synthroid: 820 reports
- Taltz: 215 reports
- Topamax: 182 reports
- Tramadol: 571 reports
- Tresiba: 119 reports
- Trulicity: 1,094 reports
- Tylenol: 553 reports
- Tymlos: 465 reports
- Ventolin: 190 reports
- Vicodin: 168 reports
- Victoza: 287 reports
- Vitamin b12: 489 reports
- Vitamin c: 329 reports
- Vitamin d: 1,409 reports
- Vitamin d3: 417 reports
- Vitamin e: 171 reports
- Vitamins: 356 reports
- Vivitrol: 184 reports
- Voltaren: 117 reports
- Wellbutrin: 265 reports
- Xanax: 368 reports
- Xarelto: 154 reports
- Xeljanz: 187 reports
- Xiaflex: 181 reports
- Xolair: 505 reports
- Zantac: 174 reports
- Zetia: 179 reports
- Zocor: 123 reports
- Zofran: 141 reports
- Zoloft: 268 reports
- Zolpidem: 122 reports
- Zyrtec: 365 reports
All the drugs that are associated with Injection site bruising:
- Injection site bruising (1,484 drugs)
Common conditions associated with Injection site bruising:
- Acid reflux: 607 reports
- Acupuncture and pain: 688 reports
- Ankylosing spondylitis: 1,458 reports
- Anticoagulant therapy: 142 reports
- Antidepressant therapy: 681 reports
- Anxiety: 536 reports
- Arthritis: 274 reports
- Asthma: 864 reports
- Back pain: 118 reports
- Birth control: 255 reports
- Birth control and family planning: 245 reports
- Blood cholesterol increased: 3,520 reports
- Blood pressure abnormal: 311 reports
- Blood pressure - high: 956 reports
- Blood pressure inadequately controlled: 157 reports
- Blood pressure management: 167 reports
- Blood triglycerides abnormal: 3,520 reports
- Blood triglycerides increased: 3,520 reports
- Cardiac disorder: 169 reports
- Colitis ulcerative: 890 reports
- Contraception: 245 reports
- Crohns: 3,045 reports
- Crohn's disease: 3,045 reports
- Crohns disease: 3,045 reports
- Depression: 629 reports
- Diabetes: 1,123 reports
- Diabetes mellitus: 1,135 reports
- Diabetes mellitus insulin-dependent: 190 reports
- Diabetes mellitus management: 1,197 reports
- Diabetes mellitus non-insulin-dependent: 2,387 reports
- Diabetes - type 2: 4,251 reports
- Diabetic type 2: 4,106 reports
- Dm: 1,122 reports
- Dyslipidemia: 3,520 reports
- Dyssomnia: 297 reports
- Family planning and contraception: 255 reports
- Fibromyalgia: 116 reports
- Fibrositis: 121 reports
- Gastroesophageal reflux disease: 633 reports
- Gastro-oesophageal reflux disease: 633 reports
- Gastrooesophageal reflux disease: 633 reports
- General physical condition: 432 reports
- Gerd: 607 reports
- Gerds: 633 reports
- Granulomatous ileocolitis: 3,045 reports
- Growth hormone deficiency: 293 reports
- Hbp: 956 reports
- Headache: 166 reports
- Hepatitis c: 331 reports
- High blood cholesterol: 3,841 reports
- High blood cholesterol and triglycerides: 3,619 reports
- High blood pressure: 999 reports
- High cholesterol: 3,619 reports
- Hormone replacement therapy: 116 reports
- Hypercholesterolaemia: 3,619 reports
- Hyperlipidemia: 3,619 reports
- Hypersensitivity: 347 reports
- Hypertension: 999 reports
- Hypnosis and pain: 931 reports
- Hypophosphatasia: 135 reports
- Hypopituitarism: 114 reports
- Hypothyroid: 396 reports
- Hypothyroidism: 396 reports
- Iddm: 184 reports
- Ileitis: 2,941 reports
- Inability to sleep: 291 reports
- Inflammatory bowel disease - crohn's disease: 3,045 reports
- Inflammatory bowel disease - ulcerative colitis: 850 reports
- Insomnia: 297 reports
- Jitters: 536 reports
- Joint aches: 132 reports
- Joint pain: 132 reports
- Jra: 366 reports
- Juvenile chronic polyarthritis: 366 reports
- Juvenile idiopathic arthritis: 366 reports
- Juvenile onset diabetes: 184 reports
- Juvenile rheumatoid arthritis: 372 reports
- Lipoprotein test: 3,520 reports
- Lupus: 182 reports
- Migraine: 1,185 reports
- Migraines: 988 reports
- Mineral supplementation: 127 reports
- Ms: 3,825 reports
- Multiple sclerosis: 3,950 reports
- Muscle spasms: 131 reports
- Myxedema: 380 reports
- Nausea: 152 reports
- Niddm: 4,106 reports
- Osteoarthritis: 111 reports
- Osteoarthritis aggravated: 111 reports
- Osteoporosis: 3,949 reports
- Osteoporosis post-menopausal: 441 reports
- Pain: 931 reports
- Pain relief by acupuncture: 902 reports
- Panhypopituitarism: 293 reports
- Parkinson's disease: 123 reports
- Peyronie's disease: 133 reports
- Pituitary dwarfism: 317 reports
- Pregnancy: 255 reports
- Preventive health care: 137 reports
- Psoriasis: 4,181 reports
- Psoriatic arthropathy: 3,445 reports
- Ra: 12,641 reports
- Regional enteritis: 3,045 reports
- Relapsing-remitting multiple sclerosis: 285 reports
- Rheumatoid arthritis: 12,291 reports
- Rheumatoid spondylitis: 1,458 reports
- Sarcoidosis: 101 reports
- Skin wrinkling: 221 reports
- Sleep aid: 291 reports
- Sleep issues: 291 reports
- Spondylarthropathy: 1,458 reports
- Spondylitis: 1,390 reports
- Still's disease: 372 reports
- Stress: 560 reports
- Stress and anxiety: 560 reports
- Supplementation therapy: 156 reports
- Systemic lupus erythematosus: 209 reports
- Thin bones: 4,070 reports
- Thrombosis: 213 reports
- Thyroid diseases: 189 reports
- Type 1 diabetes: 184 reports
- Type 1 diabetes mellitus: 184 reports
- Type 2 diabetes: 4,106 reports
- Type 2 diabetes mellitus: 4,106 reports
- Uc: 890 reports
- Ulcerative colitis: 850 reports
- Underactive thyroid: 396 reports
- Vitamin supplementation: 432 reports
- Wakefulness: 297 reports
All the conditions that are associated with Injection site bruising:
- Injection site bruising (947 conditions)
How the study uses the data?
The study uses data from the FDA. It is based on collagenase clostridium histolyticum (the active ingredients of Xiaflex) and Xiaflex (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.
Who is eHealthMe?
With medical big data and proven AI algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 600+ medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).
WARNING, DISCLAIMER, USE FOR PUBLICATION
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DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.
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