Xyrem and Respiratory distress - a phase IV clinical study of FDA data


Respiratory distress is found among people who take Xyrem, especially for people who are female, 30-39 old, have been taking the drug for < 1 month.

The phase IV clinical study analyzes which people take Xyrem and have Respiratory distress. It is created by eHealthMe based on reports of 73,973 people who have side effects when taking Xyrem from the FDA, and is updated regularly. You can use the study as a second opinion to make health care decisions.

Phase IV trials are used to detect adverse drug outcomes and monitor drug effectiveness in the real world. With medical big data and AI algorithms, eHealthMe is running millions of phase IV trials and makes the results available to the public. Our original studies have been referenced on 600+ medical publications including The Lancet, Mayo Clinic Proceedings, and Nature.

On Apr, 02, 2023

73,973 people reported to have side effects when taking Xyrem.
Among them, 36 people (0.05%) have Respiratory distress.

What is Xyrem?

Xyrem has active ingredients of sodium oxybate. It is often used in narcolepsy. eHealthMe is studying from 74,316 Xyrem users for its effectiveness, alternative drugs and more.

What is Respiratory distress?

Respiratory distress (difficulty in breathing) is found to be associated with 2,440 drugs and 1,828 conditions by eHealthMe.

Number of Xyrem and Respiratory distress reports submitted per year:

Could Xyrem cause Respiratory distress?

Time on Xyrem when people have Respiratory distress *:

  • < 1 month: 64.29 %
  • 1 - 6 months: 14.29 %
  • 6 - 12 months: 0.0 %
  • 1 - 2 years: 7.14 %
  • 2 - 5 years: 7.14 %
  • 5 - 10 years: 0.0 %
  • 10+ years: 7.14 %

Gender of people who have Respiratory distress when taking Xyrem *:

  • female: 80 %
  • male: 20 %

Age of people who have Respiratory distress when taking Xyrem *:

  • 0-1: 0.0 %
  • 2-9: 5.56 %
  • 10-19: 0.0 %
  • 20-29: 5.56 %
  • 30-39: 33.33 %
  • 40-49: 22.22 %
  • 50-59: 27.78 %
  • 60+: 5.56 %

Common drugs people take besides Xyrem *:

  1. Oxycodone: 7 people, 19.44%
  2. Vitamin D: 6 people, 16.67%
  3. Lyrica: 5 people, 13.89%
  4. Zyrtec: 4 people, 11.11%
  5. Seroquel: 4 people, 11.11%
  6. Zoloft: 4 people, 11.11%
  7. Cytomel: 4 people, 11.11%
  8. Concerta: 4 people, 11.11%
  9. Nasonex: 4 people, 11.11%
  10. Neurontin: 4 people, 11.11%

Common side effects people have besides Respiratory distress *:

  1. Weight Decreased: 11 people, 30.56%
  2. High Blood Pressure: 11 people, 30.56%
  3. Pain: 7 people, 19.44%
  4. Stress And Anxiety: 7 people, 19.44%
  5. Cognitive Disorder (mental health disorders affects learning, memory, perception, and problem solving): 6 people, 16.67%
  6. Drowsiness: 6 people, 16.67%
  7. Acute Kidney Failure: 6 people, 16.67%
  8. Intervertebral Disc Protrusion (spinal disc protrusion): 6 people, 16.67%
  9. Consciousness - Decreased: 5 people, 13.89%
  10. Heart Palpitations (feelings or sensations that your heart is pounding or racing): 5 people, 13.89%

Common conditions people have *:

  1. Belligerence (aggressive or warlike behaviour): 2 people, 5.56%
  2. Alcoholism (problems with alcohol): 2 people, 5.56%
  3. Stress And Anxiety: 1 person, 2.78%
  4. Pain: 1 person, 2.78%
  5. Nasopharyngeal Cancer (cancer of nasopharynx): 1 person, 2.78%
  6. Convulsion (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled shaking of the body): 1 person, 2.78%

* Approximation only. Some reports may have incomplete information.

Do you take Xyrem and have Respiratory distress?

Check whether Respiratory distress is associated with a drug or a condition

How to use the study?

You can discuss the study with your doctor, to ensure that all drug risks and benefits are fully discussed and understood.

Related studies

How severe was Respiratory distress and when was it recovered:

Expand to all the drugs that have ingredients of sodium oxybate:

Alternative drugs to, pros and cons of Xyrem:

Common Xyrem side effects:

Browse all side effects of Xyrem:

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Respiratory distress treatments and more:

COVID vaccines that are related to Respiratory distress:

Common drugs associated with Respiratory distress:

All the drugs that are associated with Respiratory distress:

Common conditions associated with Respiratory distress:

All the conditions that are associated with Respiratory distress:

How the study uses the data?

The study uses data from the FDA. It is based on sodium oxybate (the active ingredients of Xyrem) and Xyrem (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

Who is eHealthMe?

With medical big data and proven AI algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 600+ medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).


WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.

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