Zantac and Bradykinesia - a phase IV clinical study of FDA data


We study 431,038 people who have side effects when taking Zantac. Bradykinesia is found, especially among people who are male, 60+ old, also take Metoclopramide and have Herpes zoster.

The phase IV clinical study analyzes which people take Zantac and have Bradykinesia. It is created by eHealthMe based on reports from the FDA, and is updated regularly. You may use the study as a second opinion to make health care decisions.

Phase IV trials are used to detect adverse drug outcomes and monitor drug effectiveness in the real world. With medical big data and AI algorithms, eHealthMe is running millions of phase IV trials and makes the results available to the public. Our original studies have been referenced on 700+ medical publications including The Lancet, Mayo Clinic Proceedings, and Nature.

On Oct, 03, 2023

431,038 people reported to have side effects when taking Zantac.
Among them, 13 people (0.0%) have Bradykinesia.

What is Zantac?

Zantac has active ingredients of ranitidine hydrochloride. It is used in gastroesophageal reflux disease. Currently, eHealthMe is studying from 433,180 Zantac users.

What is Bradykinesia?

Bradykinesia (decreased bodily movement. it is associated with basal ganglia diseases) is found to be associated with 808 drugs and 446 conditions by eHealthMe. Currently, we are studying 6,111 people who have Bradykinesia.

Number of Zantac and Bradykinesia reports submitted per year:

Could Zantac cause Bradykinesia?

Gender of people who have Bradykinesia when taking Zantac *:

  • female: 15.38 %
  • male: 84.62 %

Age of people who have Bradykinesia when taking Zantac *:

  • 0-1: 0.0 %
  • 2-9: 0.0 %
  • 10-19: 0.0 %
  • 20-29: 0.0 %
  • 30-39: 0.0 %
  • 40-49: 0.0 %
  • 50-59: 11.11 %
  • 60+: 88.89 %

Common drugs people take besides Zantac *:

  1. Metoclopramide: 7 people, 53.85%
  2. Sinemet: 5 people, 38.46%
  3. Acyclovir: 5 people, 38.46%
  4. Cordarone: 5 people, 38.46%
  5. Klonopin: 5 people, 38.46%
  6. Coumadin: 5 people, 38.46%
  7. Valium: 5 people, 38.46%
  8. Protonix: 4 people, 30.77%
  9. Ranitidine: 3 people, 23.08%
  10. Neurontin: 3 people, 23.08%

Common side effects people have besides Bradykinesia *:

  1. Movement - Uncoordinated: 6 people, 46.15%
  2. Tremor (trembling or shaking movements in one or more parts of your body): 6 people, 46.15%
  3. Emotional Disorder: 6 people, 46.15%
  4. Parkinson's Disease: 6 people, 46.15%
  5. Headache (pain in head): 5 people, 38.46%
  6. Confusional State: 5 people, 38.46%
  7. Overdose: 5 people, 38.46%
  8. Gait Disturbance: 5 people, 38.46%
  9. Tardive Dyskinesia (a disorder that involves involuntary movements): 5 people, 38.46%
  10. Extrapyramidal Disorder (involuntary muscle spasms in the face and neck): 5 people, 38.46%

Common conditions people have *:

  1. Herpes Zoster: 5 people, 38.46%
  2. Atrial Fibrillation/flutter (atrial fibrillation and flutter are abnormal heart rhythms in which the atria, or upper chambers of the heart, are out of sync with the ventricles): 4 people, 30.77%
  3. Malignant Melanoma (skin cancer rises from melancytes): 1 person, 7.69%
  4. Gastrointestinal Motility Disorder (abnormal intestinal contractions): 1 person, 7.69%

* Approximation only. Some reports may have incomplete information.

Do you take Zantac and have Bradykinesia?

Check whether Bradykinesia is associated with a drug or a condition

How to use the study?

You can discuss the study with your doctor, to ensure that all drug risks and benefits are fully discussed and understood.

Related studies

Zantac side effects by duration, gender and age:

Bradykinesia treatments and more:

Common drugs associated with Bradykinesia:

All the drugs that are associated with Bradykinesia:

Common conditions associated with Bradykinesia:

All the conditions that are associated with Bradykinesia:

How the study uses the data?

The study uses data from the FDA. It is based on ranitidine hydrochloride (the active ingredients of Zantac) and Zantac (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

Who is eHealthMe?

With medical big data and proven AI algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 700+ medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).


WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.

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