Zantac and Rheumatoid arthritis - a phase IV clinical study of FDA data

Summary:

We study 365,012 people who have side effects when taking Zantac. Rheumatoid arthritis is found, especially among people who are female, 60+ old, have been taking the drug for 10+ years, also take Nexium and have Pain.

The phase IV clinical study analyzes which people take Zantac and have Rheumatoid arthritis. It is created by eHealthMe based on reports from the FDA, and is updated regularly. You may use the study as a second opinion to make health care decisions.

Phase IV trials are used to detect adverse drug outcomes and monitor drug effectiveness in the real world. With medical big data and AI algorithms, eHealthMe is running millions of phase IV trials and makes the results available to the public. Our original studies have been referenced on 700+ medical publications including The Lancet, Mayo Clinic Proceedings, and Nature.

On Aug, 23, 2023

365,012 people reported to have side effects when taking Zantac.
Among them, 438 people (0.12%) have Rheumatoid arthritis.

What is Zantac?

Zantac has active ingredients of ranitidine hydrochloride. It is used in gastroesophageal reflux disease. Currently, eHealthMe is studying from 433,180 Zantac users.

What is Rheumatoid arthritis?

Rheumatoid arthritis (a chronic progressive disease causing inflammation in the joints) is found to be associated with 2,838 drugs and 2,038 conditions by eHealthMe. Currently, we are studying 1,046,716 people who have Rheumatoid arthritis.

Number of Zantac and Rheumatoid arthritis reports submitted per year:

Could Zantac cause Rheumatoid arthritis?

* Approximation only. Some reports may have incomplete information.

Do you take Zantac and have Rheumatoid arthritis?

Check whether Rheumatoid arthritis is associated with a drug or a condition

How to use the study?

You can discuss the study with your doctor, to ensure that all drug risks and benefits are fully discussed and understood.

Related publications that referenced our studies

Mathai, P. C., Andrade, N. N., Aggarwal, N., Nerurkar, S., & Kapoor, P. , "Low-dose methotrexate in rheumatoid arthritis: a potential risk factor for bisphosphonate-induced osteonecrosis of the jaw", Oral and maxillofacial surgery, 2018 Jan .
Azuma N, Matsui K, Hashimoto N, Yoshikawa T, Sano H, "Successful Switch to Golimumab for Eosinophilia and Skin Symptoms Related to Multiple Biologics in a Patient with Rheumatoid Arthritis", Internal Medicine, 2017 Jun .
Saif MW, "Rheumatoid arthritis associated with the use of Sandostatin? LAR? depot in a patient with pancreatic neuroendocrine tumor", An association or a coincidence? The first case report, 2017 Jan .
Ahmed AB, Radwan AM, Baddary HM, "Prevalence of Generalized Anxiety Disorder in Patients with Rheumatoid Arthritis and its Relationship with Disease Activity", The Egyptian Journal of Hospital Medicine, 2016 Jan .

Related studies

Zantac side effects by duration, gender and age:

Zantac side effects (433,180 reports)

Rheumatoid arthritis treatments and more:

Rheumatoid arthritis (1,046,716 reports)

Common drugs associated with Rheumatoid arthritis:

All the drugs that are associated with Rheumatoid arthritis:

Rheumatoid arthritis (2,838 drugs)

Common conditions associated with Rheumatoid arthritis:

Pain: 3,972 reports
High blood pressure: 3,281 reports
Osteoporosis: 2,349 reports

All the conditions that are associated with Rheumatoid arthritis:

Rheumatoid arthritis (2,038 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on ranitidine hydrochloride (the active ingredients of Zantac) and Zantac (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

Who is eHealthMe?

With medical big data and proven AI algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 700+ medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.