Zantac and Tumor perforation - a phase IV clinical study of FDA data


Tumor perforation is reported only by a few people who take Zantac.

The phase IV clinical study analyzes which people take Zantac and have Tumor perforation. It is created by eHealthMe based on reports of 365,012 people who have side effects while taking Zantac from the FDA, and is updated regularly.

Phase IV trials are used to detect adverse drug outcomes and monitor drug effectiveness in the real world. With medical big data and AI algorithms, eHealthMe is running millions of phase IV trials and makes the results available to the public. Our original studies have been referenced on 600+ medical publications including The Lancet, Mayo Clinic Proceedings, and Nature.

On Mar, 24, 2023

365,012 people reported to have side effects when taking Zantac.
Among them, 2 people (0.0%) have Tumor perforation.

What is Zantac?

Zantac has active ingredients of ranitidine hydrochloride. It is often used in gastroesophageal reflux disease. eHealthMe is studying from 367,148 Zantac users for its effectiveness, alternative drugs and more.

What is Tumor perforation?

Tumor perforation is found to be associated with 144 drugs and 81 conditions by eHealthMe.

Number of Zantac and Tumor perforation reports submitted per year:

Could Zantac cause Tumor perforation?

Gender of people who have Tumor perforation when taking Zantac *:

  • female: 100 %
  • male: 0.0 %

Age of people who have Tumor perforation when taking Zantac *:

  • 0-1: 0.0 %
  • 2-9: 0.0 %
  • 10-19: 0.0 %
  • 20-29: 0.0 %
  • 30-39: 0.0 %
  • 40-49: 100 %
  • 50-59: 0.0 %
  • 60+: 0.0 %

Common drugs people take besides Zantac *:

  1. Ms Contin: 2 people, 100.00%
  2. Compazine: 2 people, 100.00%
  3. Oxycodone: 1 person, 50.00%

Common side effects people have besides Tumor perforation *:

  1. Pneumoperitoneum (air or gas in the abdominal (peritoneal) cavity): 2 people, 100.00%

* Approximation only. Some reports may have incomplete information.

Do you take Zantac and have Tumor perforation?

Check whether Tumor perforation is associated with a drug or a condition

How to use the study?

You can discuss the study with your doctor, to ensure that all drug risks and benefits are fully discussed and understood.

Related studies

How severe was Tumor perforation and when was it recovered:

Expand to all the drugs that have ingredients of ranitidine hydrochloride:

Alternative drugs to, pros and cons of Zantac:

Common Zantac side effects:

Browse all side effects of Zantac:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Tumor perforation treatments and more:

COVID vaccines that are related to Tumor perforation:

All the drugs that are associated with Tumor perforation:

All the conditions that are associated with Tumor perforation:

How the study uses the data?

The study uses data from the FDA. It is based on ranitidine hydrochloride (the active ingredients of Zantac) and Zantac (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

Who is eHealthMe?

With medical big data and proven AI algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 600+ medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).


WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.

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