Zepatier and Peripheral swelling - a phase IV clinical study of FDA data


We study 4,462 people who have side effects when taking Zepatier. Peripheral swelling is found, especially among people who are female, 60+ old, have been taking the drug for < 1 month, also take Amlodipine and have Hepatitis c.

The phase IV clinical study analyzes which people take Zepatier and have Peripheral swelling. It is created by eHealthMe based on reports from the FDA, and is updated regularly. You may use the study as a second opinion to make health care decisions.

Phase IV trials are used to detect adverse drug outcomes and monitor drug effectiveness in the real world. With medical big data and AI algorithms, eHealthMe is running millions of phase IV trials and makes the results available to the public. Our original studies have been referenced on 700+ medical publications including The Lancet, Mayo Clinic Proceedings, and Nature.

On Sep, 30, 2023

4,462 people reported to have side effects when taking Zepatier.
Among them, 44 people (0.99%) have Peripheral swelling.

What is Zepatier?

Zepatier has active ingredients of elbasvir; grazoprevir. Currently, eHealthMe is studying from 4,463 Zepatier users.

What is Peripheral swelling?

Peripheral swelling is found to be associated with 2,600 drugs and 1,662 conditions by eHealthMe. Currently, we are studying 156,380 people who have Peripheral swelling.

Number of Zepatier and Peripheral swelling reports submitted per year:

Could Zepatier cause Peripheral swelling?

Time on Zepatier when people have Peripheral swelling *:

  • < 1 month: 50.0 %
  • 1 - 6 months: 37.5 %
  • 6 - 12 months: 12.5 %
  • 1 - 2 years: 0.0 %
  • 2 - 5 years: 0.0 %
  • 5 - 10 years: 0.0 %
  • 10+ years: 0.0 %

Gender of people who have Peripheral swelling when taking Zepatier *:

  • female: 52.38 %
  • male: 47.62 %

Age of people who have Peripheral swelling when taking Zepatier *:

  • 0-1: 0.0 %
  • 2-9: 0.0 %
  • 10-19: 0.0 %
  • 20-29: 0.0 %
  • 30-39: 3.45 %
  • 40-49: 13.79 %
  • 50-59: 41.38 %
  • 60+: 41.38 %

Common drugs people take besides Zepatier *:

  1. Amlodipine: 3 people, 6.82%
  2. Naprosyn: 2 people, 4.55%
  3. Isentress: 2 people, 4.55%
  4. Xanax: 1 person, 2.27%
  5. Suboxone: 1 person, 2.27%
  6. Sovaldi: 1 person, 2.27%
  7. Oxycodone: 1 person, 2.27%
  8. Hydrocodone: 1 person, 2.27%
  9. Flexeril: 1 person, 2.27%
  10. Depakote: 1 person, 2.27%

Common side effects people have besides Peripheral swelling *:

  1. Pain In Extremity: 7 people, 15.91%
  2. Fatigue (feeling of tiredness): 6 people, 13.64%
  3. Nausea (feeling of having an urge to vomit): 4 people, 9.09%
  4. Insomnia (sleeplessness): 3 people, 6.82%
  5. Joint Swelling: 3 people, 6.82%
  6. Headache (pain in head): 3 people, 6.82%
  7. Spinal Pain (pain in spine): 2 people, 4.55%
  8. Dysstasia (difficulty in standing): 2 people, 4.55%
  9. Hyperhidrosis (abnormally increased sweating): 2 people, 4.55%
  10. Joint Pain: 2 people, 4.55%

Common conditions people have *:

  1. Hepatitis C: 24 people, 54.55%
  2. Hiv Infection: 2 people, 4.55%
  3. High Blood Pressure: 1 person, 2.27%
  4. Hepatitis Chronic Active: 1 person, 2.27%

* Approximation only. Some reports may have incomplete information.

Do you take Zepatier and have Peripheral swelling?

Check whether Peripheral swelling is associated with a drug or a condition

How to use the study?

You can discuss the study with your doctor, to ensure that all drug risks and benefits are fully discussed and understood.

Related studies

Zepatier side effects by duration, gender and age:

Peripheral swelling treatments and more:

Common drugs associated with Peripheral swelling:

All the drugs that are associated with Peripheral swelling:

Common conditions associated with Peripheral swelling:

All the conditions that are associated with Peripheral swelling:

How the study uses the data?

The study uses data from the FDA. It is based on elbasvir; grazoprevir (the active ingredients of Zepatier) and Zepatier (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

Who is eHealthMe?

With medical big data and proven AI algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 700+ medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).


WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.

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