Zestoretic and Exostosis - a phase IV clinical study of FDA data


Exostosis is found among people who take Zestoretic, especially for people who are male, 60+ old, have been taking the drug for 2 - 5 years.

The phase IV clinical study analyzes which people take Zestoretic and have Exostosis. It is created by eHealthMe based on reports of 4,049 people who have side effects when taking Zestoretic from the FDA, and is updated regularly. You can use the study as a second opinion to make health care decisions.

Phase IV trials are used to detect adverse drug outcomes and monitor drug effectiveness in the real world. With medical big data and AI algorithms, eHealthMe is running millions of phase IV trials and makes the results available to the public. Our original studies have been referenced on 600+ medical publications including The Lancet, Mayo Clinic Proceedings, and Nature.

On Apr, 02, 2023

4,049 people reported to have side effects when taking Zestoretic.
Among them, 15 people (0.37%) have Exostosis.

What is Zestoretic?

Zestoretic has active ingredients of hydrochlorothiazide; lisinopril. It is often used in high blood pressure. eHealthMe is studying from 4,195 Zestoretic users for its effectiveness, alternative drugs and more.

What is Exostosis?

Exostosis (formation of new bone on the surface of a bone) is found to be associated with 1,657 drugs and 923 conditions by eHealthMe.

Number of Zestoretic and Exostosis reports submitted per year:

Could Zestoretic cause Exostosis?

Time on Zestoretic when people have Exostosis *:

  • < 1 month: 0.0 %
  • 1 - 6 months: 0.0 %
  • 6 - 12 months: 0.0 %
  • 1 - 2 years: 0.0 %
  • 2 - 5 years: 100 %
  • 5 - 10 years: 0.0 %
  • 10+ years: 0.0 %

Gender of people who have Exostosis when taking Zestoretic *:

  • female: 33.33 %
  • male: 66.67 %

Age of people who have Exostosis when taking Zestoretic *:

  • 0-1: 0.0 %
  • 2-9: 0.0 %
  • 10-19: 0.0 %
  • 20-29: 0.0 %
  • 30-39: 0.0 %
  • 40-49: 0.0 %
  • 50-59: 14.29 %
  • 60+: 85.71 %

Common drugs people take besides Zestoretic *:

  1. Vioxx: 11 people, 73.33%
  2. Ibuprofen: 2 people, 13.33%
  3. Lisinopril: 2 people, 13.33%
  4. Plavix: 2 people, 13.33%
  5. Magnesium: 2 people, 13.33%
  6. Lortab: 2 people, 13.33%
  7. Glucophage: 2 people, 13.33%
  8. Coumadin: 2 people, 13.33%
  9. Vicodin: 2 people, 13.33%
  10. Gemfibrozil: 1 person, 6.67%

Common side effects people have besides Exostosis *:

  1. Stress And Anxiety: 13 people, 86.67%
  2. Heart Attack: 12 people, 80.00%
  3. High Blood Cholesterol: 11 people, 73.33%
  4. Ventricular Arrhythmia (problem with the rate or rhythm of the heartbeat): 10 people, 66.67%
  5. Cardiac Disorder: 10 people, 66.67%
  6. Atelectasis (partial or complete collapse of the lung): 10 people, 66.67%
  7. Transient Ischaemic Attack (a transient episode of neurologic dysfunction caused by ischemia (loss of blood flow)): 10 people, 66.67%
  8. Coronary Artery Reocclusion (blockage after treatment of coronary artery): 9 people, 60.00%
  9. Coronary Heart Disease (narrowing or blockage of the coronary arteries): 9 people, 60.00%
  10. Stroke (sudden death of a portion of the brain cells due to a lack of oxygen): 8 people, 53.33%

Common conditions people have *:

  1. Carpal Tunnel Syndrome (nerve compression at wrist results numbness weakness, pain , swelling): 9 people, 60.00%
  2. Ventricular Dysfunction (heart dysfunction): 1 person, 6.67%
  3. Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 1 person, 6.67%
  4. Postmenopause: 1 person, 6.67%
  5. Pain: 1 person, 6.67%
  6. Osteoporosis (bones weak and more likely to break): 1 person, 6.67%
  7. Multiple Myeloma (cancer of the plasma cells): 1 person, 6.67%
  8. High Blood Cholesterol: 1 person, 6.67%
  9. Fibromyalgia (a long-term condition which causes pain all over the body): 1 person, 6.67%
  10. Depression: 1 person, 6.67%

* Approximation only. Some reports may have incomplete information.

Do you take Zestoretic and have Exostosis?

Check whether Exostosis is associated with a drug or a condition

How to use the study?

You can discuss the study with your doctor, to ensure that all drug risks and benefits are fully discussed and understood.

Related studies

How severe was Exostosis and when was it recovered:

Expand to all the drugs that have ingredients of hydrochlorothiazide; lisinopril:

Alternative drugs to, pros and cons of Zestoretic:

Common Zestoretic side effects:

Browse all side effects of Zestoretic:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Exostosis treatments and more:

COVID vaccines that are related to Exostosis:

Common drugs associated with Exostosis:

All the drugs that are associated with Exostosis:

Common conditions associated with Exostosis:

All the conditions that are associated with Exostosis:

How the study uses the data?

The study uses data from the FDA. It is based on hydrochlorothiazide; lisinopril (the active ingredients of Zestoretic) and Zestoretic (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

Who is eHealthMe?

With medical big data and proven AI algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 600+ medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).


WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.

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