Ziac and Insomnia - a phase IV clinical study of FDA data
Summary:
Insomnia is found among people who take Ziac, especially for people who are female, 60+ old.
The phase IV clinical study analyzes which people take Ziac and have Insomnia. It is created by eHealthMe based on reports of 4,150 people who have side effects when taking Ziac from the FDA, and is updated regularly. You can use the study as a second opinion to make health care decisions.
Phase IV trials are used to detect adverse drug outcomes and monitor drug effectiveness in the real world. With medical big data and AI algorithms, eHealthMe is running millions of phase IV trials and makes the results available to the public. Our original studies have been referenced on 600+ medical publications including The Lancet, Mayo Clinic Proceedings, and Nature.
4,150 people reported to have side effects when taking Ziac.
Among them, 137 people (3.3%) have Insomnia.
What is Ziac?
Ziac has active ingredients of bisoprolol fumarate; hydrochlorothiazide. It is often used in high blood pressure. eHealthMe is studying from 4,389 Ziac users for its effectiveness, alternative drugs and more.
What is Insomnia?
Insomnia (sleeplessness) is found to be associated with 4,595 drugs and 4,885 conditions by eHealthMe.
Number of Ziac and Insomnia reports submitted per year:

Gender of people who have Insomnia when taking Ziac*:
Age of people who have Insomnia when taking Ziac *:
Common drugs people take besides Ziac *:
Common side effects people have besides Insomnia *:
Common conditions people have *:
* Approximation only. Some reports may have incomplete information.
Do you take Ziac and have Insomnia?
Check whether Insomnia is associated with a drug or a conditionHow to use the study?
You can discuss the study with your doctor, to ensure that all drug risks and benefits are fully discussed and understood.
Related studies
How severe was Insomnia and when was it recovered:
Expand to all the drugs that have ingredients of bisoprolol fumarate; hydrochlorothiazide:
Alternative drugs to, pros and cons of Ziac:
- Ziac (4,389 reports)
Common Ziac side effects:
- High blood pressure: 342 reports
- Weakness: 314 reports
- Fatigue (feeling of tiredness): 286 reports
- Diarrhea: 264 reports
- Pain: 250 reports
- Drug ineffective: 249 reports
Browse all side effects of Ziac:
a b c d e f g h i j k l m n o p q r s t u v w x y zInsomnia treatments and more:
- Insomnia (387,957 reports)
COVID vaccines that are related to Insomnia:
- Insomnia in Moderna COVID Vaccine
- Insomnia in Pfizer BioNTech Covid Vaccine
- Insomnia in Johnson and Johnson Covid Vaccine
Common drugs associated with Insomnia:
- Prednisone: 11,837 reports
- Aspirin: 10,926 reports
- Lyrica: 10,535 reports
- Cymbalta: 9,690 reports
- Seroquel: 7,933 reports
- Methotrexate: 7,481 reports
- Humira: 7,415 reports
- Omeprazole: 7,272 reports
- Gabapentin: 7,176 reports
- Synthroid: 7,110 reports
All the drugs that are associated with Insomnia:
- Insomnia (4,595 drugs)
Common conditions associated with Insomnia:
- Depression: 16,686 reports
- Pain: 12,769 reports
- Multiple sclerosis: 12,002 reports
- High blood pressure: 11,095 reports
- Rheumatoid arthritis: 10,870 reports
- Stress and anxiety: 9,545 reports
All the conditions that are associated with Insomnia:
- Insomnia (4,885 conditions)
How the study uses the data?
The study uses data from the FDA. It is based on bisoprolol fumarate; hydrochlorothiazide (the active ingredients of Ziac) and Ziac (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.
Who is eHealthMe?
With medical big data and proven AI algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 600+ medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).
WARNING, DISCLAIMER, USE FOR PUBLICATION
WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.
DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.
If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.
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