Ziac and Osteoporosis - a phase IV clinical study of FDA data


Osteoporosis is found among people who take Ziac, especially for people who are female, 40-49 old.

The phase IV clinical study analyzes which people take Ziac and have Osteoporosis. It is created by eHealthMe based on reports of 4,150 people who have side effects when taking Ziac from the FDA, and is updated regularly. You can use the study as a second opinion to make health care decisions.

Phase IV trials are used to detect adverse drug outcomes and monitor drug effectiveness in the real world. With medical big data and AI algorithms, eHealthMe is running millions of phase IV trials and makes the results available to the public. Our original studies have been referenced on 600+ medical publications including The Lancet, Mayo Clinic Proceedings, and Nature.

On Feb, 07, 2023

4,150 people reported to have side effects when taking Ziac.
Among them, 21 people (0.51%) have Osteoporosis.

What is Ziac?

Ziac has active ingredients of bisoprolol fumarate; hydrochlorothiazide. It is often used in high blood pressure. eHealthMe is studying from 4,390 Ziac users for its effectiveness, alternative drugs and more.

What is Osteoporosis?

Osteoporosis (bones weak and more likely to break) is found to be associated with 2,561 drugs and 1,858 conditions by eHealthMe.

Number of Ziac and Osteoporosis reports submitted per year:

Could Ziac cause Osteoporosis?

Gender of people who have Osteoporosis when taking Ziac *:

  • female: 90.48 %
  • male: 9.52 %

Age of people who have Osteoporosis when taking Ziac *:

  • 0-1: 0.0 %
  • 2-9: 0.0 %
  • 10-19: 0.0 %
  • 20-29: 0.0 %
  • 30-39: 0.0 %
  • 40-49: 44.44 %
  • 50-59: 16.67 %
  • 60+: 38.89 %

Common drugs people take besides Ziac *:

  1. Zometa: 9 people, 42.86%
  2. Ambien: 9 people, 42.86%
  3. Aredia: 9 people, 42.86%
  4. Cephalexin: 9 people, 42.86%
  5. Lexapro: 9 people, 42.86%
  6. Lortab: 9 people, 42.86%
  7. Zithromax: 8 people, 38.10%
  8. Vicodin: 8 people, 38.10%
  9. Norco: 8 people, 38.10%
  10. Synthroid: 8 people, 38.10%

Common side effects people have besides Osteoporosis *:

  1. Weight Increased: 10 people, 47.62%
  2. Depression: 10 people, 47.62%
  3. Intervertebral Disc Degeneration (spinal disc degeneration): 9 people, 42.86%
  4. Joint Pain: 9 people, 42.86%
  5. Hepatic Steatosis (fatty liver disease): 9 people, 42.86%
  6. Fatigue (feeling of tiredness): 9 people, 42.86%
  7. Metastases To Bone (cancer spreads to bone): 9 people, 42.86%
  8. Dry Skin: 9 people, 42.86%
  9. Renal Cyst (kidney cyst): 9 people, 42.86%
  10. Dental Fistula: 9 people, 42.86%

Common conditions people have *:

  1. Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 5 people, 23.81%
  2. Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 2 people, 9.52%
  3. Arthritis (form of joint disorder that involves inflammation of one or more joints): 2 people, 9.52%
  4. Hypothyroidism (abnormally low activity of the thyroid gland, resulting in retardation of growth and mental development): 1 person, 4.76%
  5. Breast Cancer: 1 person, 4.76%
  6. Bone Disorder: 1 person, 4.76%

* Approximation only. Some reports may have incomplete information.

Do you take Ziac and have Osteoporosis?

Check whether Osteoporosis is associated with a drug or a condition

How to use the study?

You can discuss the study with your doctor, to ensure that all drug risks and benefits are fully discussed and understood.

Related publications that referenced our studies

Related studies

How severe was Osteoporosis and when was it recovered:

Expand to all the drugs that have ingredients of bisoprolol fumarate; hydrochlorothiazide:

Alternative drugs to, pros and cons of Ziac:

  • Ziac (4,390 reports)

Common Ziac side effects:

Browse all side effects of Ziac:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Osteoporosis treatments and more:

COVID vaccines that are related to Osteoporosis:

Common drugs associated with Osteoporosis:

All the drugs that are associated with Osteoporosis:

Common conditions associated with Osteoporosis:

All the conditions that are associated with Osteoporosis:

How the study uses the data?

The study uses data from the FDA. It is based on bisoprolol fumarate; hydrochlorothiazide (the active ingredients of Ziac) and Ziac (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

Who is eHealthMe?

With medical big data and proven AI algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 600+ medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).


WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.

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