Zidovudine and Ototoxicity - a phase IV clinical study of FDA data
Summary:
Ototoxicity is reported only by a few people who take Zidovudine.
The phase IV clinical study analyzes which people take Zidovudine and have Ototoxicity. It is created by eHealthMe based on reports of 9,692 people who have side effects while taking Zidovudine from the FDA, and is updated regularly.
Phase IV trials are used to detect adverse drug outcomes and monitor drug effectiveness in the real world. With medical big data and AI algorithms, eHealthMe is running millions of phase IV trials and makes the results available to the public. Our original studies have been referenced on 600+ medical publications including The Lancet, Mayo Clinic Proceedings, and Nature.
9,692 people reported to have side effects when taking Zidovudine.
Among them, 3 people (0.03%) have Ototoxicity.
What is Zidovudine?
Zidovudine has active ingredients of zidovudine. eHealthMe is studying from 9,331 Zidovudine users for its effectiveness, alternative drugs and more.
What is Ototoxicity?
Ototoxicity (damage to the ear) is found to be associated with 598 drugs and 336 conditions by eHealthMe.
Number of Zidovudine and Ototoxicity reports submitted per year:
Time on Zidovudine when people have Ototoxicity *:
- < 1 month: 0.0 %
- 1 - 6 months: 0.0 %
- 6 - 12 months: 0.0 %
- 1 - 2 years: 100 %
- 2 - 5 years: 0.0 %
- 5 - 10 years: 0.0 %
- 10+ years: 0.0 %
Gender of people who have Ototoxicity when taking Zidovudine *:
- female: 33.33 %
- male: 66.67 %
Age of people who have Ototoxicity when taking Zidovudine *:
- 0-1: 0.0 %
- 2-9: 0.0 %
- 10-19: 0.0 %
- 20-29: 0.0 %
- 30-39: 66.67 %
- 40-49: 33.33 %
- 50-59: 0.0 %
- 60+: 0.0 %
Common drugs people take besides Zidovudine *:
- Lamivudine: 2 people, 66.67%
- Zerit: 1 person, 33.33%
- Viread: 1 person, 33.33%
- Azithromycin: 1 person, 33.33%
- Copegus: 1 person, 33.33%
- Epivir: 1 person, 33.33%
- Ethambutol Hydrochloride: 1 person, 33.33%
- Fluconazole: 1 person, 33.33%
- Ipratropium Bromide: 1 person, 33.33%
- Isoniazid: 1 person, 33.33%
Common side effects people have besides Ototoxicity *:
- Tinnitus (a ringing in the ears): 2 people, 66.67%
- Hypoacusis (loss of hearing): 1 person, 33.33%
- Hearing Impaired: 1 person, 33.33%
- Dizziness: 1 person, 33.33%
- Deafness Neurosensory: 1 person, 33.33%
Common conditions people have *:
- Mycobacterium Kansasii Infection (bacterial infection): 1 person, 33.33%
- Hiv Infection: 1 person, 33.33%
* Approximation only. Some reports may have incomplete information.
Do you take Zidovudine and have Ototoxicity?
Check whether Ototoxicity is associated with a drug or a conditionHow to use the study?
You can discuss the study with your doctor, to ensure that all drug risks and benefits are fully discussed and understood.
Related studies
How severe was Ototoxicity and when was it recovered:
Expand to all the drugs that have ingredients of zidovudine:
Alternative drugs to, pros and cons of Zidovudine:
- Zidovudine (9,331 reports)
Common Zidovudine side effects:
- Abdominal distension: 170 reports
- Abdominal pain: 253 reports
- Agranulocytosis (a deficiency of granulocytes in the blood, causing increased vulnerability to infection): 432 reports
- Alanine aminotransferase increased: 321 reports
- Anaemia (lack of blood): 753 reports
- Anaemia neonatal: 176 reports
- Arrhythmias (irregular heartbeat): 125 reports
- Aseptic necrosis (the death of bone tissue due to a lack of blood supply): 104 reports
- Aspartate aminotransferase increased: 299 reports
- Birth control: 191 reports
- Blood alkaline phosphatase increased: 122 reports
- Blood bilirubin increased: 161 reports
- Blood creatine phosphokinase increased: 232 reports
- Blood creatinine increased: 152 reports
- Blood lactate dehydrogenase increased: 117 reports
- Blood lactic acid increased: 399 reports
- Breathing difficulty: 120 reports
- Cardiac murmur (an heart sound in valve abnormality): 230 reports
- Chest pain: 117 reports
- Complications of maternal exposure to therapeutic drugs: 236 reports
- Congenital anomaly (birth defect): 157 reports
- Cough: 189 reports
- Death: 185 reports
- Dehydration (dryness resulting from the removal of water): 139 reports
- Diarrhea: 442 reports
- Dizziness: 122 reports
- Drug exposure during pregnancy: 1,081 reports
- Drug ineffective: 179 reports
- Drug resistance (reduction in effectiveness of a drug): 129 reports
- Drug toxicity: 112 reports
- Fatigue (feeling of tiredness): 258 reports
- Fever: 699 reports
- Foetal exposure during pregnancy (exposing your unborn child to contraindicated in pregnancy leads birth defect): 119 reports
- Gamma-glutamyltransferase increased: 153 reports
- Haemoglobin decreased: 223 reports
- Headache (pain in head): 156 reports
- Heart attack: 150 reports
- Hepatic failure (liver failure): 129 reports
- Hepatitis (inflammation of the liver): 110 reports
- Hepatomegaly (abnormal enlargement of the liver): 198 reports
- Hepatotoxicity (chemical-driven liver damage): 113 reports
- High blood cholesterol: 227 reports
- High blood pressure: 147 reports
- Hiv infection: 143 reports
- Hyperlactacidaemia (the acidosis and also reduces the capacity of the kidney): 103 reports
- Hyperlipidaemia (presence of excess lipids in the blood): 213 reports
- Hypertriglyceridaemia (excess of triglycerides in the blood): 276 reports
- Immune reconstitution syndrome (immune recovery syndrome): 349 reports
- Joint pain: 121 reports
- Lactic acidosis (low ph in body tissues): 268 reports
- Lipodystrophy acquired (a regional loss of subcutaneous adipose tissue which usually starts in the face, extends downward acquired): 208 reports
- Lymph follicular hypertrophy (an increase in the size of the lymph node follicles): 171 reports
- Malaise (a feeling of general discomfort or uneasiness): 197 reports
- Maternal drugs affecting foetus (chemical affecting the baby before birth taken by mother): 763 reports
- Mitochondrial toxicity (a condition in which the mitochondria of a body's cells become damaged or decline significantly in number;): 109 reports
- Muscle aches (muscle pain): 118 reports
- Nausea (feeling of having an urge to vomit): 411 reports
- Nausea and vomiting: 315 reports
- Neonatal disorder (disease of neonates): 306 reports
- Neutropenia neonatal (an abnormally low number of neutrophils in below a month baby): 198 reports
- Pancreatitis (inflammation of pancreas): 152 reports
- Pancytopenia (medical condition in which there is a reduction in the number of red and white blood cells, as well as platelets): 148 reports
- Pneumonia: 168 reports
- Portal hypertension (increase in the blood pressure within a system of veins called the portal venous system): 111 reports
- Premature baby: 515 reports
- Rashes (redness): 240 reports
- Renal failure acute (rapid kidney dysfunction): 157 reports
- Renal impairment (severely reduced kidney function): 137 reports
- Respiratory distress (difficulty in breathing): 102 reports
- Sepsis (a severe blood infection that can lead to organ failure and death): 200 reports
- Small for dates baby (an unborn baby is growing more slowly and is smaller than most babies are at the same age): 127 reports
- Stillbirth (a birth of dead foetus): 119 reports
- Sudden infant death syndrome: 101 reports
- Thrombocytopenia (decrease of platelets in blood): 251 reports
- Weakness: 272 reports
- Weight decreased: 188 reports
Browse all side effects of Zidovudine:
a b c d e f g h i j k l m n o p q r s t u v w x y zOtotoxicity treatments and more:
- Ototoxicity (1,631 reports)
COVID vaccines that are related to Ototoxicity:
- Ototoxicity in Moderna COVID Vaccine
- Ototoxicity in Pfizer BioNTech Covid Vaccine
- Ototoxicity in Johnson and Johnson Covid Vaccine
Common drugs associated with Ototoxicity:
- Carboplatin: 234 reports
- Cisplatin: 258 reports
- Etoposide: 170 reports
- Gentamicin: 147 reports
All the drugs that are associated with Ototoxicity:
- Ototoxicity (598 drugs)
All the conditions that are associated with Ototoxicity:
- Ototoxicity (336 conditions)
How the study uses the data?
The study uses data from the FDA. It is based on zidovudine (the active ingredients of Zidovudine) and Zidovudine (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.
Who is eHealthMe?
With medical big data and proven AI algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 600+ medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).
WARNING, DISCLAIMER, USE FOR PUBLICATION
WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.
DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.
If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.
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