Zoloft and Depression aggravated - a phase IV clinical study of FDA data
Summary:
We study 125,609 people who have side effects when taking Zoloft. Depression aggravated is found, especially among people who are female, 60+ old, have been taking the drug for 1 - 6 months, also take Xanax and have Pain.
The phase IV clinical study analyzes which people take Zoloft and have Depression aggravated. It is created by eHealthMe based on reports from the FDA, and is updated regularly. You may use the study as a second opinion to make health care decisions.
Phase IV trials are used to detect adverse drug outcomes and monitor drug effectiveness in the real world. With medical big data and AI algorithms, eHealthMe is running millions of phase IV trials and makes the results available to the public. Our original studies have been referenced on 700+ medical publications including The Lancet, Mayo Clinic Proceedings, and Nature.
125,609 people reported to have side effects when taking Zoloft.
Among them, 8,970 people (7.14%) have Depression aggravated.
What is Zoloft?
Zoloft has active ingredients of sertraline hydrochloride. It is used in depression. Currently, eHealthMe is studying from 136,115 Zoloft users.
What is Depression aggravated?
Depression aggravated is found to be associated with 1,881 drugs and 687 conditions by eHealthMe. Currently, we are studying 2,253 people who have Depression aggravated.
Number of Zoloft and Depression aggravated reports submitted per year:

Time on Zoloft when people have Depression aggravated *:
Gender of people who have Depression aggravated when taking Zoloft*:
Age of people who have Depression aggravated when taking Zoloft *:
Common drugs people take besides Zoloft *:
Common side effects people have besides Depression aggravated *:
Common conditions people have *:
* Approximation only. Some reports may have incomplete information.
Do you take Zoloft and have Depression aggravated?
Check whether Depression aggravated is associated with a drug or a conditionHow to use the study?
You can discuss the study with your doctor, to ensure that all drug risks and benefits are fully discussed and understood.
Related publications that referenced our studies
- Izgi C, Erdem G, Mansuroglu D, Kurtoglu N, Kara M, Gunesdogdu F, "Severe hypokalemia probably associated with sertraline use", Annals of Pharmacotherapy, 2014 Jan .
Related studies
Zoloft side effects by duration, gender and age:
- Zoloft side effects (136,115 reports)
Depression aggravated treatments and more:
- Depression aggravated (2,253 reports)
Common drugs associated with Depression aggravated:
- Chantix: 11,936 reports
- Prednisone: 11,218 reports
- Aspirin: 10,276 reports
- Oxycontin: 9,844 reports
- Accutane: 9,826 reports
- Zoloft: 8,970 reports
- Fosamax: 8,630 reports
- Cymbalta: 8,215 reports
- Vioxx: 8,039 reports
- Xanax: 7,767 reports
All the drugs that are associated with Depression aggravated:
- Depression aggravated (1,881 drugs)
Common conditions associated with Depression aggravated:
- Multiple sclerosis: 20,384 reports
- Depression: 19,325 reports
- Pain: 12,961 reports
- High blood pressure: 10,256 reports
- Rheumatoid arthritis: 10,067 reports
- Stress and anxiety: 9,456 reports
All the conditions that are associated with Depression aggravated:
- Depression aggravated (687 conditions)
How the study uses the data?
The study uses data from the FDA. It is based on sertraline hydrochloride (the active ingredients of Zoloft) and Zoloft (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.
Who is eHealthMe?
With medical big data and proven AI algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 700+ medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).
WARNING, DISCLAIMER, USE FOR PUBLICATION
WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.
DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.
If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.
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