Zoloft and Gastrointestinal perforation - a phase IV clinical study of FDA data


Gastrointestinal perforation is found among people who take Zoloft, especially for people who are female, 60+ old, have been taking the drug for < 1 month.

The phase IV clinical study analyzes which people take Zoloft and have Gastrointestinal perforation. It is created by eHealthMe based on reports of 118,546 people who have side effects when taking Zoloft from the FDA, and is updated regularly. You can use the study as a second opinion to make health care decisions.

With medical big data and AI algorithms, eHealthMe enables everyone to run phase IV clinical trial to detect adverse drug outcomes and monitor effectiveness. Our original studies have been referenced on 600+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Most recently, phase IV clinial trails for COVID 19 vaccines have been added, check here.

On Aug, 01, 2022

118,546 people reported to have side effects when taking Zoloft.
Among them, 56 people (0.05%) have Gastrointestinal perforation.

What is Zoloft?

Zoloft has active ingredients of sertraline hydrochloride. It is often used in depression. eHealthMe is studying from 128,469 Zoloft users for its effectiveness, alternative drugs and more.

What is Gastrointestinal perforation?

Gastrointestinal perforation (hole in the digestive tract) is found to be associated with 1,577 drugs and 1,209 conditions by eHealthMe.

Number of Zoloft and Gastrointestinal perforation reports submitted per year:

Could Zoloft cause Gastrointestinal perforation?

Time on Zoloft when people have Gastrointestinal perforation *:

  • < 1 month: 66.67 %
  • 1 - 6 months: 0.0 %
  • 6 - 12 months: 0.0 %
  • 1 - 2 years: 0.0 %
  • 2 - 5 years: 33.33 %
  • 5 - 10 years: 0.0 %
  • 10+ years: 0.0 %

Gender of people who have Gastrointestinal perforation when taking Zoloft *:

  • female: 64.29 %
  • male: 35.71 %

Age of people who have Gastrointestinal perforation when taking Zoloft *:

  • 0-1: 0.0 %
  • 2-9: 2.33 %
  • 10-19: 0.0 %
  • 20-29: 0.0 %
  • 30-39: 6.98 %
  • 40-49: 11.63 %
  • 50-59: 20.93 %
  • 60+: 58.14 %

Common drugs people take besides Zoloft *:

  1. Synthroid: 11 people, 19.64%
  2. Prilosec: 9 people, 16.07%
  3. Flomax: 8 people, 14.29%
  4. Neurontin: 8 people, 14.29%
  5. Zyrtec: 7 people, 12.50%
  6. Lorazepam: 6 people, 10.71%
  7. Decadron: 6 people, 10.71%
  8. Benadryl: 6 people, 10.71%
  9. Avastin: 6 people, 10.71%
  10. Imodium: 5 people, 8.93%

Common side effects people have besides Gastrointestinal perforation *:

  1. Dehydration (dryness resulting from the removal of water): 9 people, 16.07%
  2. Hypotension (abnormally low blood pressure): 9 people, 16.07%
  3. Weakness: 8 people, 14.29%
  4. Abdominal Pain: 8 people, 14.29%
  5. Nausea And Vomiting: 8 people, 14.29%
  6. Peritonitis (inflammation of the peritoneum, the thin tissue that lines the inner wall of the abdomen and covers most of the abdominal organs): 8 people, 14.29%
  7. Fall: 7 people, 12.50%
  8. Rashes (redness): 7 people, 12.50%
  9. Nausea (feeling of having an urge to vomit): 7 people, 12.50%
  10. Insomnia (sleeplessness): 6 people, 10.71%

Common conditions people have *:

  1. Crohn's Disease (condition that causes inflammation of the gastrointestinal tract): 6 people, 10.71%
  2. Pain: 6 people, 10.71%
  3. Ovarian Cancer (cancer of ovary): 4 people, 7.14%
  4. Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 4 people, 7.14%
  5. High Blood Pressure: 4 people, 7.14%
  6. Asthma: 4 people, 7.14%
  7. Multiple Myeloma (cancer of the plasma cells): 4 people, 7.14%
  8. Constipation: 3 people, 5.36%
  9. Sleep Disorder: 3 people, 5.36%
  10. Nausea (feeling of having an urge to vomit): 3 people, 5.36%

* Approximation only. Some reports may have incomplete information.

Do you take Zoloft and have Gastrointestinal perforation?

Check whether Gastrointestinal perforation is associated with a drug or a condition

How to use the study?

You can discuss the study with your doctor, to ensure that all drug risks and benefits are fully discussed and understood.

Related publications that referenced our studies

Related studies

Alternative drugs to, pros and cons of Zoloft:

Gastrointestinal perforation treatments and more:

COVID vaccines that are related to Gastrointestinal perforation:

How severe was Gastrointestinal perforation and when was it recovered:

Expand to all the drugs that have ingredients of sertraline hydrochloride:

Common drugs associated with Gastrointestinal perforation:

All the drugs that are associated with Gastrointestinal perforation:

Common conditions associated with Gastrointestinal perforation:

All the conditions that are associated with Gastrointestinal perforation:

How the study uses the data?

The study uses data from the FDA. It is based on sertraline hydrochloride (the active ingredients of Zoloft) and Zoloft (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

Who is eHealthMe?

With medical big data and proven AI algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 600+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).


WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.

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