Zoloft and Ototoxicity - a phase IV clinical study of FDA data


Ototoxicity is reported only by a few people who take Zoloft.

The phase IV clinical study analyzes which people take Zoloft and have Ototoxicity. It is created by eHealthMe based on reports of 118,546 people who have side effects while taking Zoloft from the FDA, and is updated regularly.

With medical big data and AI algorithms, eHealthMe enables everyone to run phase IV clinical trial to detect adverse drug outcomes and monitor effectiveness. Our original studies have been referenced on 600+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Most recently, phase IV clinial trails for COVID 19 vaccines have been added, check here.

On May, 25, 2022

118,546 people reported to have side effects when taking Zoloft.
Among them, 5 people (0.0%) have Ototoxicity.

What is Zoloft?

Zoloft has active ingredients of sertraline hydrochloride. It is often used in depression. eHealthMe is studying from 128,469 Zoloft users for its effectiveness, alternative drugs and more.

What is Ototoxicity?

Ototoxicity (damage to the ear) is found to be associated with 597 drugs and 335 conditions by eHealthMe.

Number of Zoloft and Ototoxicity reports submitted per year:

Could Zoloft cause Ototoxicity?

Gender of people who have Ototoxicity when taking Zoloft *:

  • female: 80 %
  • male: 20 %

Age of people who have Ototoxicity when taking Zoloft *:

  • 0-1: 0.0 %
  • 2-9: 0.0 %
  • 10-19: 0.0 %
  • 20-29: 0.0 %
  • 30-39: 50 %
  • 40-49: 25 %
  • 50-59: 0.0 %
  • 60+: 25 %

Common drugs people take besides Zoloft *:

  1. Ambien: 2 people, 40.00%
  2. Cipro: 2 people, 40.00%
  3. Floxin Otic: 2 people, 40.00%
  4. Xarelto: 1 person, 20.00%
  5. Atarax: 1 person, 20.00%
  6. Ativan: 1 person, 20.00%
  7. Avelox: 1 person, 20.00%
  8. Cortisporin: 1 person, 20.00%
  9. Fosamax: 1 person, 20.00%
  10. Gravol: 1 person, 20.00%

Common side effects people have besides Ototoxicity *:

  1. Hyperacusis (disorder in loudness perception): 2 people, 40.00%
  2. Neuralgia (pain in one or more nerves): 2 people, 40.00%
  3. Temporomandibular Joint Syndrome (pain at the temporomandibular joint due to various causes of increased muscle tension and spasm. it is believed that syndrome is a physical manifestation of psychological stress): 2 people, 40.00%
  4. Tinnitus (a ringing in the ears): 2 people, 40.00%
  5. Ruptured Eardrum (tear in eardrum): 2 people, 40.00%
  6. Hearing Impaired: 2 people, 40.00%
  7. Complex Regional Pain Syndrome (long lasting pain condition most often affecting one of the limbs (arms, legs, hands, or feet)): 2 people, 40.00%
  8. Conductive Deafness (deafness due to a problem in conducting sound waves): 2 people, 40.00%
  9. Hypoacusis (loss of hearing): 2 people, 40.00%
  10. Ear Disorder: 2 people, 40.00%

Common conditions people have *:

  1. Sleep Disorder: 1 person, 20.00%
  2. Otitis Externa (external ear infection): 1 person, 20.00%
  3. Metastatic Malignant Melanoma (spreadable cancer tumour of melanine): 1 person, 20.00%
  4. Insomnia (sleeplessness): 1 person, 20.00%

* Approximation only. Some reports may have incomplete information.

Do you take Zoloft and have Ototoxicity?

Check whether Ototoxicity is associated with a drug or a condition

How to use the study?

You can discuss the study with your doctor, to ensure that all drug risks and benefits are fully discussed and understood.

Related publications that referenced our studies

Related studies

Alternative drugs to, pros and cons of Zoloft:

Ototoxicity treatments and more:

COVID vaccines that are related to Ototoxicity:

How severe was Ototoxicity and when was it recovered:

Expand to all the drugs that have ingredients of sertraline hydrochloride:

Common drugs associated with Ototoxicity:

All the drugs that are associated with Ototoxicity:

All the conditions that are associated with Ototoxicity:

How the study uses the data?

The study uses data from the FDA. It is based on sertraline hydrochloride (the active ingredients of Zoloft) and Zoloft (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

Who is eHealthMe?

With medical big data and proven AI algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 600+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).


WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.

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