Zometa and Exostosis - a phase IV clinical study of FDA data
Summary:
We study 68,309 people who have side effects when taking Zometa. Exostosis is found, especially among people who are female, 60+ old, have been taking the drug for 2 - 5 years, also take Aredia and have Metastases to bone.
The phase IV clinical study analyzes which people take Zometa and have Exostosis. It is created by eHealthMe based on reports from the FDA, and is updated regularly. You may use the study as a second opinion to make health care decisions.
What are phase IV trials?
Phase IV trials are used to detect adverse drug outcomes and monitor drug effectiveness in the real world. With medical big data and AI algorithms, eHealthMe is running millions of phase IV trials and makes the results available to the public. Our original studies have been referenced on 700+ medical publications including The Lancet, Mayo Clinic Proceedings, and Nature.
68,309 people reported to have side effects when taking Zometa.
Among them, 1,330 people (1.95%) have Exostosis.
What is Zometa?
Zometa has active ingredients of zoledronic acid. It is used in multiple myeloma. Currently, eHealthMe is studying from 70,203 Zometa users.
What is Exostosis?
Exostosis (formation of new bone on the surface of a bone) is found to be associated with 1,694 drugs and 924 conditions by eHealthMe. Currently, we are studying 12,965 people who have Exostosis.
Number of Zometa and Exostosis reports submitted per year:

Time on Zometa when people have Exostosis *:
Gender of people who have Exostosis when taking Zometa*:
Age of people who have Exostosis when taking Zometa *:
Common drugs people take besides Zometa *:
Common side effects people have besides Exostosis *:
Common conditions people have *:
* Approximation only. Some reports may have incomplete information.
Do you take Zometa and have Exostosis?
Check whether Exostosis is associated with a drug or a conditionHow to use the study?
You can discuss the study with your doctor, to ensure that all drug risks and benefits are fully discussed and understood.
Related studies
How severe was Exostosis and when was it recovered:
Expand to all the drugs that have ingredients of zoledronic acid:
- Exostosis and drugs with ingredients of zoledronic acid (1,429 reports)
Alternative drugs to, pros and cons of Zometa:
- Zometa (70,203 reports)
Browse all side effects of Zometa:
a b c d e f g h i j k l m n o p q r s t u v w x y zExostosis treatments and more:
- Exostosis (12,965 reports)
Common drugs associated with Exostosis:
- Fosamax: 2,383 reports
- Humira: 1,868 reports
- Zometa: 1,330 reports
- Methotrexate: 1,313 reports
- Prednisone: 1,307 reports
- Enbrel: 1,141 reports
- Aspirin: 959 reports
- Aredia: 807 reports
- Celebrex: 745 reports
- Gabapentin: 694 reports
All the drugs that are associated with Exostosis:
- Exostosis (1,694 drugs)
Common conditions associated with Exostosis:
- Rheumatoid arthritis: 2,387 reports
- Osteoporosis: 2,190 reports
- Pain: 931 reports
- High blood pressure: 870 reports
All the conditions that are associated with Exostosis:
- Exostosis (924 conditions)
How the study uses the data?
The study uses data from the FDA. It is based on zoledronic acid (the active ingredients of Zometa) and Zometa (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.
Who is eHealthMe?
With medical big data and proven AI algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 700+ medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).
WARNING, DISCLAIMER, USE FOR PUBLICATION
WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.
DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.
If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.
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