Zopiclone and Brain compression - a phase IV clinical study of FDA data


Brain compression is found among people who take Zopiclone, especially for people who are male, 40-49 old.

The phase IV clinical study analyzes which people take Zopiclone and have Brain compression. It is created by eHealthMe based on reports of 41,014 people who have side effects when taking Zopiclone from the FDA, and is updated regularly. You can use the study as a second opinion to make health care decisions.

Phase IV trials are used to detect adverse drug outcomes and monitor drug effectiveness in the real world. With medical big data and AI algorithms, eHealthMe is running millions of phase IV trials and makes the results available to the public. Our original studies have been referenced on 600+ medical publications including The Lancet, Mayo Clinic Proceedings, and Nature.

On May, 26, 2023

41,014 people reported to have side effects when taking Zopiclone.
Among them, 8 people (0.02%) have Brain compression.

What is Zopiclone?

Zopiclone has active ingredients of eszopiclone. It is often used in insomnia. eHealthMe is studying from 42,671 Zopiclone users for its effectiveness, alternative drugs and more.

What is Brain compression?

Brain compression is found to be associated with 363 drugs and 186 conditions by eHealthMe.

Number of Zopiclone and Brain compression reports submitted per year:

Could Zopiclone cause Brain compression?

Gender of people who have Brain compression when taking Zopiclone *:

  • female: 0.0 %
  • male: 100 %

Age of people who have Brain compression when taking Zopiclone *:

  • 0-1: 0.0 %
  • 2-9: 0.0 %
  • 10-19: 0.0 %
  • 20-29: 0.0 %
  • 30-39: 0.0 %
  • 40-49: 87.5 %
  • 50-59: 0.0 %
  • 60+: 12.5 %

Common drugs people take besides Zopiclone *:

  1. Paracetamol: 5 people, 62.50%
  2. Pantoprazole: 5 people, 62.50%
  3. Enstilar: 5 people, 62.50%
  4. Morphine: 4 people, 50.00%
  5. Oxycontin: 2 people, 25.00%
  6. Lyrica: 2 people, 25.00%
  7. Innohep: 2 people, 25.00%
  8. Ramipril: 1 person, 12.50%
  9. Metoprolol Succinate: 1 person, 12.50%
  10. Imdur: 1 person, 12.50%

Common side effects people have besides Brain compression *:

  1. Thrombocytopenia (decrease of platelets in blood): 5 people, 62.50%
  2. Intracranial Tumor Haemorrhage: 5 people, 62.50%
  3. Fever: 5 people, 62.50%
  4. Aspartate Aminotransferase Increased: 5 people, 62.50%
  5. Malignant Neoplasm Progression (cancer tumour came back): 4 people, 50.00%
  6. Hemiplegia (paralysis of one side of the body): 3 people, 37.50%
  7. Death: 3 people, 37.50%
  8. Renal Impairment (severely reduced kidney function): 2 people, 25.00%
  9. Renal Cancer Metastatic (cancer of kidney spreads to other part): 2 people, 25.00%
  10. General Physical Condition Abnormal: 2 people, 25.00%

Common conditions people have *:

  1. Hepatocellular Carcinoma (liver cancer): 5 people, 62.50%
  2. Pain: 4 people, 50.00%
  3. Stress And Anxiety: 2 people, 25.00%
  4. Renal Cancer Metastatic (cancer of kidney spreads to other part): 2 people, 25.00%
  5. Pulmonary Embolism (blockage of the main artery of the lung): 2 people, 25.00%
  6. Neuralgia (pain in one or more nerves): 2 people, 25.00%
  7. Malnutrition (condition that results from eating a diet in which certain nutrients are lacking): 2 people, 25.00%

* Approximation only. Some reports may have incomplete information.

Do you take Zopiclone and have Brain compression?

Check whether Brain compression is associated with a drug or a condition

How to use the study?

You can discuss the study with your doctor, to ensure that all drug risks and benefits are fully discussed and understood.

Related publications that referenced our studies

Related studies

How severe was Brain compression and when was it recovered:

Expand to all the drugs that have ingredients of eszopiclone:

Alternative drugs to, pros and cons of Zopiclone:

Common Zopiclone side effects:

Browse all side effects of Zopiclone:

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Brain compression treatments and more:

COVID vaccines that are related to Brain compression:

All the drugs that are associated with Brain compression:

All the conditions that are associated with Brain compression:

How the study uses the data?

The study uses data from the FDA. It is based on eszopiclone (the active ingredients of Zopiclone) and Zopiclone (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

Who is eHealthMe?

With medical big data and proven AI algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 600+ medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).


WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.

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