Zopiclone and Gynecomastia - a phase IV clinical study of FDA data


Gynecomastia is found among people who take Zopiclone, especially for people who are male, 50-59 old.

The phase IV clinical study analyzes which people take Zopiclone and have Gynecomastia. It is created by eHealthMe based on reports of 41,014 people who have side effects when taking Zopiclone from the FDA, and is updated regularly. You can use the study as a second opinion to make health care decisions.

Phase IV trials are used to detect adverse drug outcomes and monitor drug effectiveness in the real world. With medical big data and AI algorithms, eHealthMe is running millions of phase IV trials and makes the results available to the public. Our original studies have been referenced on 600+ medical publications including The Lancet, Mayo Clinic Proceedings, and Nature.

On Nov, 09, 2022

41,014 people reported to have side effects when taking Zopiclone.
Among them, 20 people (0.05%) have Gynecomastia.

What is Zopiclone?

Zopiclone has active ingredients of eszopiclone. It is often used in insomnia. eHealthMe is studying from 42,615 Zopiclone users for its effectiveness, alternative drugs and more.

What is Gynecomastia?

Gynecomastia (enlargement of the gland tissue of the male breast) is found to be associated with 1,446 drugs and 523 conditions by eHealthMe.

Number of Zopiclone and Gynecomastia reports submitted per year:

Could Zopiclone cause Gynecomastia?

Gender of people who have Gynecomastia when taking Zopiclone *:

  • female: 5 %
  • male: 95 %

Age of people who have Gynecomastia when taking Zopiclone *:

  • 0-1: 0.0 %
  • 2-9: 0.0 %
  • 10-19: 0.0 %
  • 20-29: 0.0 %
  • 30-39: 12.5 %
  • 40-49: 0.0 %
  • 50-59: 81.25 %
  • 60+: 6.25 %

Common drugs people take besides Zopiclone *:

  1. Lipitor: 9 people, 45.00%
  2. Ativan: 9 people, 45.00%
  3. Dilaudid: 9 people, 45.00%
  4. Crestor: 7 people, 35.00%
  5. Lyrica: 7 people, 35.00%
  6. Onglyza: 6 people, 30.00%
  7. Viagra: 6 people, 30.00%
  8. Cotazym: 6 people, 30.00%
  9. Librax: 6 people, 30.00%
  10. Vitamin D: 6 people, 30.00%

Common side effects people have besides Gynecomastia *:

  1. Back Pain: 12 people, 60.00%
  2. Restless Leg Syndrome (a powerful urge to move your legs): 9 people, 45.00%
  3. Left Ventricular Hypertrophy (the thickening of the myocardium (muscle) of the left ventricle of the heart): 9 people, 45.00%
  4. Sleep Apnea Syndrome: 9 people, 45.00%
  5. Renal Cyst (kidney cyst): 7 people, 35.00%
  6. Oedema Peripheral (superficial swelling): 7 people, 35.00%
  7. Enlarged Heart: 6 people, 30.00%
  8. Diabetes: 6 people, 30.00%
  9. Drowsiness: 6 people, 30.00%
  10. Drug Ineffective: 6 people, 30.00%

Common conditions people have *:

  1. Hyperlipidaemia (presence of excess lipids in the blood): 10 people, 50.00%
  2. Dumping Syndrome (a condition that can develop after surgery to remove all or part of your stomach or after surgery to bypass your stomach to help you lose weight): 6 people, 30.00%
  3. Restless Leg Syndrome (a powerful urge to move your legs): 6 people, 30.00%
  4. Pain: 5 people, 25.00%
  5. Arthritis (form of joint disorder that involves inflammation of one or more joints): 3 people, 15.00%
  6. Faeces Hard: 3 people, 15.00%
  7. Constipation: 3 people, 15.00%
  8. Neuralgia (pain in one or more nerves): 3 people, 15.00%
  9. Diarrhea: 2 people, 10.00%
  10. Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 2 people, 10.00%

* Approximation only. Some reports may have incomplete information.

Do you take Zopiclone and have Gynecomastia?

Check whether Gynecomastia is associated with a drug or a condition

How to use the study?

You can discuss the study with your doctor, to ensure that all drug risks and benefits are fully discussed and understood.

Related publications that referenced our studies

Related studies

How severe was Gynecomastia and when was it recovered:

Expand to all the drugs that have ingredients of eszopiclone:

Alternative drugs to, pros and cons of Zopiclone:

Common Zopiclone side effects:

Browse all side effects of Zopiclone:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Gynecomastia treatments and more:

COVID vaccines that are related to Gynecomastia:

Common drugs associated with Gynecomastia:

All the drugs that are associated with Gynecomastia:

Common conditions associated with Gynecomastia:

All the conditions that are associated with Gynecomastia:

How the study uses the data?

The study uses data from the FDA. It is based on eszopiclone (the active ingredients of Zopiclone) and Zopiclone (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

Who is eHealthMe?

With medical big data and proven AI algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 600+ medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).


WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.

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