Acetaminophen and Anaphylaxis (expanded source)

Anaphylaxis is found among people who take Acetaminophen, especially for people who are female, 60+ old , have been taking the drug for < 1 month, also take medication Aspirin, and have High blood pressure. This review analyzes which people have Anaphylaxis with Acetaminophen. It is created by eHealthMe based on reports of 75,194 people who have side effects when taking Acetaminophen from FDA and eHealthme, and is updated regularly.


On Jun, 24, 2018

75,194 people reported to have side effects when taking Acetaminophen.
Among them, 490 people (0.65%) have Anaphylaxis

Number of reports submitted per year:

Could Acetaminophen cause Anaphylaxis?

Time on Acetaminophen when people have Anaphylaxis *:

  • < 1 month: 100 %
  • 1 - 6 months: 0.0 %
  • 6 - 12 months: 0.0 %
  • 1 - 2 years: 0.0 %
  • 2 - 5 years: 0.0 %
  • 5 - 10 years: 0.0 %
  • 10+ years: 0.0 %

Gender of people who have Anaphylaxis when taking Acetaminophen *:

  • female: 58.49 %
  • male: 41.51 %

Age of people who have Anaphylaxis when taking Acetaminophen *:

  • 0-1: 0.23 %
  • 2-9: 5.48 %
  • 10-19: 8.45 %
  • 20-29: 9.59 %
  • 30-39: 11.87 %
  • 40-49: 13.7 %
  • 50-59: 19.63 %
  • 60+: 31.05 %

Top conditions involved for these people *:

  1. High Blood Pressure: 33 people, 6.73%
  2. Preventive Health Care: 17 people, 3.47%
  3. Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 13 people, 2.65%
  4. Fever: 12 people, 2.45%
  5. Upper Respiratory Tract Infection: 9 people, 1.84%
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Top co-used drugs for these people *:

  1. Aspirin: 50 people, 10.20%
  2. Prednisolone: 30 people, 6.12%
  3. Ibuprofen: 30 people, 6.12%
  4. Furosemide: 26 people, 5.31%
  5. Simvastatin: 25 people, 5.10%
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Top other side effects for these people *:

  1. Hypotension (abnormally low blood pressure): 77 people, 15.71%
  2. Breathing Difficulty: 56 people, 11.43%
  3. Urticaria (rash of round, red welts on the skin that itch intensely): 43 people, 8.78%
  4. Rashes (redness): 38 people, 7.76%
  5. Chest Pain: 34 people, 6.94%
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* Approximation only. Some reports may have incomplete information.

What's next:

Do you take Acetaminophen and have Anaphylaxis?

Related studies


Acetaminophen has active ingredients of acetaminophen. It is often used in pain. (latest outcomes from Acetaminophen 76,319 users)


Anaphylaxis (serious allergic reaction that is rapid in onset and may cause death) has been reported by people with asthma, multiple sclerosis, high blood pressure, rheumatoid arthritis, preventive health care (latest reports from 44,957 Anaphylaxis patients).

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What would happen?

Predict new side effects and undetected conditions when you take Acetaminophen and have Anaphylaxis

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NOTE: The study is based on active ingredients and brand name. Other drugs that have the same active ingredients (e.g. generic drugs) are NOT considered.

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