Methotrexate and Diarrhoea (expanded source)

Diarrhoea is found among people who take Methotrexate, especially for people who are female, 60+ old , have been taking the drug for < 1 month, also take medication Humira, and have Psoriatic arthropathy. This review analyzes which people have Diarrhoea with Methotrexate. It is created by eHealthMe based on reports of 234,104 people who have side effects when taking Methotrexate from FDA and eHealthme, and is updated regularly.

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On Apr, 12, 2018

234,104 people reported to have side effects when taking Methotrexate.
Among them, 6,841 people (2.92%) have Diarrhoea

Number of reports submitted per year:

Could Methotrexate cause Diarrhoea?

Time on Methotrexate when people have Diarrhoea *:

  • < 1 month: 38.98 %
  • 1 - 6 months: 18.04 %
  • 6 - 12 months: 8.26 %
  • 1 - 2 years: 8.82 %
  • 2 - 5 years: 12.53 %
  • 5 - 10 years: 8.82 %
  • 10+ years: 4.41 %

Gender of people who have Diarrhoea when taking Methotrexate *:

  • female: 73.4 %
  • male: 26.6 %

Age of people who have Diarrhoea when taking Methotrexate *:

  • 0-1: 1.16 %
  • 2-9: 4.19 %
  • 10-19: 6.17 %
  • 20-29: 3.89 %
  • 30-39: 6.83 %
  • 40-49: 13.87 %
  • 50-59: 26.45 %
  • 60+: 37.45 %

Severity of Diarrhoea *:

  • least: 14.29 %
  • moderate: 53.57 %
  • severe: 21.43 %
  • most severe: 10.71 %

How people recovered from Diarrhoea *:

  • while on drug: 15 %
  • after off the drug: 15 %
  • not yet: 70 %

Top conditions involved for these people *:

  • Psoriatic Arthropathy (inflammation of the skin and joints with kin condition which typically causes patches (plaques) of red, scaly skin to develop): 527 people, 7.70%
  • High Blood Pressure: 420 people, 6.14%
  • Pain: 411 people, 6.01%
  • Crohn's Disease (condition that causes inflammation of the gastrointestinal tract): 377 people, 5.51%
  • Preventive Health Care: 281 people, 4.11%

Top co-used drugs for these people *:

  • Humira: 1,473 people, 21.53%
  • Enbrel: 1,300 people, 19.00%
  • Folic Acid: 1,155 people, 16.88%
  • Prednisone: 774 people, 11.31%
  • Plaquenil: 563 people, 8.23%

Top other side effects for these people *:

  • Nausea (feeling of having an urge to vomit): 1,897 people, 27.73%
  • Nausea And Vomiting: 1,753 people, 25.62%
  • Fever: 1,048 people, 15.32%
  • Fatigue (feeling of tiredness): 1,014 people, 14.82%
  • Abdominal Pain: 1,001 people, 14.63%

* Approximation only. Some reports may have incomplete information.

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Do you take Methotrexate and have Diarrhoea?

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Related studies


Methotrexate has active ingredients of methotrexate sodium. It is often used in rheumatoid arthritis. (latest outcomes from Methotrexate 234,889 users)


Diarrhoea has been reported by people with high blood pressure, multiple sclerosis, rheumatoid arthritis, crohn's disease, pain (latest reports from 302,036 Diarrhoea patients).

Drugs that are associated with Diarrhoea
Diarrhoea (4,039 drugs)
Could your condition cause Diarrhoea
Diarrhoea (5,084 conditions)
Expand the study to include all drugs with the same ingredients
Diarrhoea and drugs with ingredients of methotrexate sodium. (6,877 reports)
Limit the study to reports from FDA only
Diarrhoea and Methotrexate from FDA reports (7,519 reports)
Methotrexate side effects
Browse all side effects of Methotrexate
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