Allegra vs. Diphenhydramine hydrochloride: side effect and effectiveness comparison - a phase IV clinical study
Summary:
We compare the side effects and drug effectiveness of Allegra and Diphenhydramine hydrochloride. The phase IV clinical study is created by eHealthMe based on reports (from sources including the FDA) of 257,782 people who take Allegra and Diphenhydramine hydrochloride, and is updated regularly. You can use the study as a second opinion to make health care decisions.
Phase IV trials are used to detect adverse drug outcomes and monitor drug effectiveness in the real world. With medical big data and AI algorithms, eHealthMe is running millions of phase IV trials and makes the results available to the public. Our original studies have been referenced on 600+ medical publications including The Lancet, Mayo Clinic Proceedings, and Nature.
257,782 people who take Allegra and Diphenhydramine hydrochloride are studied.
What is Allegra?
Allegra has active ingredients of fexofenadine hydrochloride. It is often used in allergies. eHealthMe is studying from 68,539 Allegra users for its effectiveness, alternative drugs and more.
What is Diphenhydramine hydrochloride?
Diphenhydramine hydrochloride has active ingredients of diphenhydramine hydrochloride. It is often used in insomnia. eHealthMe is studying from 15,984 Diphenhydramine hydrochloride users for its effectiveness, alternative drugs and more.
Number of reports submitted per year:

Drugs being compared in this study:
- Allegra (fexofenadine hydrochloride)
- Diphenhydramine Hydrochloride (diphenhydramine hydrochloride)
Most common side effects of the drugs, overall:
Most common side effects of the drugs, in long term (1+ years) use:
Drug effectiveness:
Allegra:
- not at all: 2.86 %
- somewhat: 19.6 %
- moderate: 37.6 %
- high: 30.06 %
- very high: 9.89 %
Diphenhydramine Hydrochloride:
- not at all: 2.9 %
- somewhat: 23.9 %
- moderate: 36.41 %
- high: 27.47 %
- very high: 9.32 %
Want to compare Allegra with Diphenhydramine hydrochloride?
Personalize this study to your gender and age (0-99+).How to use the study?
You can discuss the study with your doctor, to ensure that all drug risks and benefits are fully discussed and understood.
Related studies
Alternative drugs to, pros and cons of:
- Allegra (66,323 reports)
- Diphenhydramine hydrochloride (14,590 reports)
Common Allegra side effects:
- Drug ineffective: 9,288 reports
- Fatigue (feeling of tiredness): 3,823 reports
- Headache (pain in head): 3,484 reports
- Breathing difficulty: 3,388 reports
- Dizziness: 3,082 reports
- Rashes (redness): 2,992 reports
- Pain: 2,960 reports
- High blood pressure: 2,627 reports
Browse all side effects of Allegra:
a b c d e f g h i j k l m n o p q r s t u v w x y zCommon Diphenhydramine hydrochloride side effects:
- Drug ineffective: 2,581 reports
- High blood pressure: 2,448 reports
- Fatigue (feeling of tiredness): 2,428 reports
- Joint pain: 2,426 reports
- Pain: 2,177 reports
- Rheumatoid arthritis (a chronic progressive disease causing inflammation in the joints): 2,020 reports
- Headache (pain in head): 1,741 reports
Browse all side effects of Diphenhydramine hydrochloride:
a b c d e f g h i j k l m n o p q r s t u v w x y zHow the study uses the data?
The study is based on fexofenadine hydrochloride and diphenhydramine hydrochloride (the active ingredients of Allegra and Diphenhydramine hydrochloride, respectively). Other drugs that have the same active ingredients (e.g. generic drugs or brand names) are also considered. Dosage of drugs is not considered in the study.
Who is eHealthMe?
With medical big data and proven AI algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 600+ medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).
WARNING, DISCLAIMER, USE FOR PUBLICATION
WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.
DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.
If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.
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