Apresoline vs. Metolazone: side effect and effectiveness comparison - a phase IV clinical study
Summary:
We compare the side effects and drug effectiveness of Apresoline and Metolazone. The phase IV clinical study is created by eHealthMe based on reports (from sources including the FDA) of 21,046 people who take Apresoline and Metolazone, and is updated regularly. You can use the study as a second opinion to make health care decisions.
Phase IV trials are used to detect adverse drug outcomes and monitor drug effectiveness in the real world. With medical big data and AI algorithms, eHealthMe is running millions of phase IV trials and makes the results available to the public. Our original studies have been referenced on 600+ medical publications including The Lancet, Mayo Clinic Proceedings, and Nature.
21,046 people who take Apresoline and Metolazone are studied.
What is Apresoline?
Apresoline has active ingredients of hydralazine hydrochloride. It is often used in high blood pressure. eHealthMe is studying from 2,304 Apresoline users for its effectiveness, alternative drugs and more.
What is Metolazone?
Metolazone has active ingredients of metolazone. It is often used in swelling. eHealthMe is studying from 12,267 Metolazone users for its effectiveness, alternative drugs and more.
Number of reports submitted per year:

Drugs being compared in this study:
- Metolazone (metolazone)
- Apresoline (hydralazine hydrochloride)
Most common side effects of the drugs, overall:
Most common side effects of the drugs, in long term (1+ years) use:
Drug effectiveness:
Apresoline:
- not at all: 6.75 %
- somewhat: 30.38 %
- moderate: 38.82 %
- high: 21.52 %
- very high: 2.5300000000000002 %
Metolazone:
- not at all: 1.6099999999999999 %
- somewhat: 46.77 %
- moderate: 27.42 %
- high: 22.58 %
- very high: 1.6099999999999999 %
Want to compare Apresoline with Metolazone?
Personalize this study to your gender and age (0-99+).How to use the study?
You can discuss the study with your doctor, to ensure that all drug risks and benefits are fully discussed and understood.
Related studies
Alternative drugs to, pros and cons of:
- Apresoline (2,272 reports)
- Metolazone (12,200 reports)
Common Apresoline side effects:
- High blood pressure: 249 reports
- Acute kidney failure: 233 reports
- Chronic kidney disease: 183 reports
- Pain: 180 reports
- Fatigue (feeling of tiredness): 172 reports
- Pneumonia: 165 reports
Browse all side effects of Apresoline:
a b c d e f g h i j k l m n o p q r s t u v w x y zCommon Metolazone side effects:
- Breathing difficulty: 1,469 reports
- Acute kidney failure: 981 reports
- Hypotension (abnormally low blood pressure): 876 reports
- Fatigue (feeling of tiredness): 875 reports
- Weakness: 866 reports
Browse all side effects of Metolazone:
a b c d e f g h i j k l m n o p q r s t u v w x y zHow the study uses the data?
The study is based on hydralazine hydrochloride and metolazone (the active ingredients of Apresoline and Metolazone, respectively). Other drugs that have the same active ingredients (e.g. generic drugs or brand names) are also considered. Dosage of drugs is not considered in the study.
Who is eHealthMe?
With medical big data and proven AI algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 600+ medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).
WARNING, DISCLAIMER, USE FOR PUBLICATION
WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.
DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.
If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.
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