Atomoxetine vs. Fluoxetine hydrochloride: side effect and effectiveness comparison - a phase IV clinical study
Summary:
We compare the side effects and drug effectiveness of Atomoxetine and Fluoxetine hydrochloride. The phase IV clinical study is created by eHealthMe based on reports (from sources including the FDA) of 162,349 people who take Atomoxetine and Fluoxetine hydrochloride, and is updated regularly. You can use the study as a second opinion to make health care decisions.
Phase IV trials are used to detect adverse drug outcomes and monitor drug effectiveness in the real world. With medical big data and AI algorithms, eHealthMe is running millions of phase IV trials and makes the results available to the public. Our original studies have been referenced on 600+ medical publications including The Lancet, Mayo Clinic Proceedings, and Nature.
162,349 people who take Atomoxetine and Fluoxetine hydrochloride are studied.
What is Atomoxetine?
Atomoxetine has active ingredients of atomoxetine. It is often used in attention deficit hyperactivity disorder. eHealthMe is studying from 1,283 Atomoxetine users for its effectiveness, alternative drugs and more.
What is Fluoxetine hydrochloride?
Fluoxetine hydrochloride has active ingredients of fluoxetine hydrochloride. It is often used in depression. eHealthMe is studying from 9,835 Fluoxetine hydrochloride users for its effectiveness, alternative drugs and more.
Number of reports submitted per year:

Drugs being compared in this study:
- Atomoxetine (atomoxetine)
- Fluoxetine Hydrochloride (fluoxetine hydrochloride)
Most common side effects of the drugs, overall:
Most common side effects of the drugs, in long term (1+ years) use:
Drug effectiveness:
Atomoxetine:
- not at all: 10.26 %
- somewhat: 29.49 %
- moderate: 34.62 %
- high: 20.51 %
- very high: 5.13 %
Fluoxetine Hydrochloride:
- not at all: 4.1 %
- somewhat: 21.59 %
- moderate: 35.91 %
- high: 29.79 %
- very high: 8.61 %
Want to compare Atomoxetine with Fluoxetine hydrochloride?
Personalize this study to your gender and age (0-99+).How to use the study?
You can discuss the study with your doctor, to ensure that all drug risks and benefits are fully discussed and understood.
Related studies
Alternative drugs to, pros and cons of:
- Atomoxetine (1,174 reports)
- Fluoxetine hydrochloride (8,438 reports)
Common Atomoxetine side effects:
- Drug ineffective: 186 reports
- Irritability: 116 reports
- Stress and anxiety: 107 reports
Common Fluoxetine hydrochloride side effects:
- Abdominal pain: 213 reports
- Abdominal pain upper: 130 reports
- Agitation (state of anxiety or nervous excitement): 180 reports
- Anaemia (lack of blood): 101 reports
- Arrhythmias (irregular heartbeat): 164 reports
- Back pain: 166 reports
- Breathing difficulty: 314 reports
- Chest pain: 215 reports
- Completed suicide (act of taking one's own life): 285 reports
- Confusional state: 209 reports
- Cough: 190 reports
- Death: 226 reports
- Depression: 390 reports
- Diarrhea: 276 reports
- Dizziness: 316 reports
- Drowsiness: 258 reports
- Drug abuse and dependence: 319 reports
- Drug ineffective: 391 reports
- Electrocardiogram qt prolonged: 150 reports
- Fainting (loss of consciousness and postural tone): 134 reports
- Fall: 230 reports
- Fatigue (feeling of tiredness): 460 reports
- Fever: 169 reports
- Foetal exposure during pregnancy (exposing your unborn child to contraindicated in pregnancy leads birth defect): 232 reports
- Gait disturbance: 119 reports
- Headache (pain in head): 408 reports
- High blood pressure: 287 reports
- Hyperhidrosis (abnormally increased sweating): 133 reports
- Hypotension (abnormally low blood pressure): 220 reports
- Insomnia (sleeplessness): 269 reports
- Intentional overdose: 104 reports
- Intentional self-injury: 120 reports
- Itching: 154 reports
- Joint pain: 225 reports
- Loss of consciousness: 125 reports
- Malaise (a feeling of general discomfort or uneasiness): 254 reports
- Memory loss: 186 reports
- Nausea (feeling of having an urge to vomit): 463 reports
- Nausea and vomiting: 304 reports
- Oedema peripheral (superficial swelling): 102 reports
- Overdose: 204 reports
- Pain: 319 reports
- Pain in extremity: 148 reports
- Paraesthesia (sensation of tingling, tickling, prickling, pricking, or burning of a person's skin with no apparent long-term physical effect): 142 reports
- Pneumonia: 155 reports
- Rashes (redness): 165 reports
- Serotonin syndrome (occurs when two drugs that affect the body's level of serotonin are taken together at the same time): 139 reports
- Stress and anxiety: 379 reports
- Suicidal ideation: 232 reports
- Suicide attempt: 271 reports
- Tremor (trembling or shaking movements in one or more parts of your body): 215 reports
- Urinary tract infection: 120 reports
- Weakness: 230 reports
- Weight decreased: 205 reports
- Weight increased: 220 reports
How the study uses the data?
The study is based on atomoxetine and fluoxetine hydrochloride (the active ingredients of Atomoxetine and Fluoxetine hydrochloride, respectively). Other drugs that have the same active ingredients (e.g. generic drugs or brand names) are also considered. Dosage of drugs is not considered in the study.
Who is eHealthMe?
With medical big data and proven AI algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 600+ medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).
WARNING, DISCLAIMER, USE FOR PUBLICATION
WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.
DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.
If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.
Recent studies on eHealthMe:
- How effective is Mometasone Furoate for Asthma? - now
- How effective is Astelin for Asthma? - 5 seconds ago
- Tagamet and Aortic Valve Replacement - 9 seconds ago
- How effective is Xopenex Hfa for Asthma Aggravated? - 14 seconds ago
- Metformin and Bronchospasm - 17 seconds ago
- Cranberry Juice and Prilosec drug interaction - 17 seconds ago
- How effective is Ventolin for Asthma Aggravated? - 18 seconds ago
- How effective is Symbicort for Asthma Aggravated? - 22 seconds ago
- How effective is Solu-Medrol for Asthma Aggravated? - 26 seconds ago
- Dyazide and Hyperkalemia - 27 seconds ago