Axid vs. Singulair: side effect and effectiveness comparison - a phase IV clinical study
Summary:
We compare the side effects and drug effectiveness of Axid and Singulair. The phase IV clinical study is created by eHealthMe based on reports (from sources including the FDA) of 178,603 people who take Axid and Singulair, and is updated regularly. You can use the study as a second opinion to make health care decisions.
Phase IV trials are used to detect adverse drug outcomes and monitor drug effectiveness in the real world. With medical big data and AI algorithms, eHealthMe is running millions of phase IV trials and makes the results available to the public. Our original studies have been referenced on 600+ medical publications including The Lancet, Mayo Clinic Proceedings, and Nature.
178,603 people who take Axid and Singulair are studied.
What is Axid?
Axid has active ingredients of nizatidine. It is often used in gastroesophageal reflux disease. eHealthMe is studying from 2,939 Axid users for its effectiveness, alternative drugs and more.
What is Singulair?
Singulair has active ingredients of montelukast sodium. It is often used in asthma. eHealthMe is studying from 115,425 Singulair users for its effectiveness, alternative drugs and more.
Number of reports submitted per year:

Drugs being compared in this study:
- Axid (nizatidine)
- Singulair (montelukast sodium)
Most common side effects of the drugs, overall:
Most common side effects of the drugs, in long term (1+ years) use:
Drug effectiveness:
Axid:
- not at all: 0 %
- somewhat: 12.5 %
- moderate: 34.38 %
- high: 46.88 %
- very high: 6.25 %
Singulair:
- not at all: 2.24 %
- somewhat: 20.17 %
- moderate: 34.03 %
- high: 30.84 %
- very high: 12.73 %
Want to compare Axid with Singulair?
Personalize this study to your gender and age (0-99+).How to use the study?
You can discuss the study with your doctor, to ensure that all drug risks and benefits are fully discussed and understood.
Related publications that referenced our studies
- Das S, Mondal S, Dey JK, Bandyopadhyay S, Saha I, Tripathi SK, "A case of montelukast induced hypercholesterolemia, severe hypertriglyceridemia and pancreatitis", Journal of Young Pharmacists, 2013 Jun .
Related studies
Alternative drugs to, pros and cons of:
Common Axid side effects:
- Chronic kidney disease: 332 reports
- Pain: 243 reports
- Weakness: 215 reports
- Chest pain: 209 reports
- Acute kidney failure: 208 reports
- Headache (pain in head): 199 reports
- Fatigue (feeling of tiredness): 196 reports
- Nausea and vomiting: 180 reports
Browse all side effects of Axid:
a b c d e f g h i j k l m n o p q r s t u v w x y zCommon Singulair side effects:
- Asthma: 15,229 reports
- Breathing difficulty: 14,467 reports
- Cough: 9,131 reports
- Fatigue (feeling of tiredness): 9,051 reports
- Headache (pain in head): 7,885 reports
- Drug ineffective: 7,681 reports
- Wheezing (a high-pitched whistling sound made while you breath): 7,374 reports
Browse all side effects of Singulair:
a b c d e f g h i j k l m n o p q r s t u v w x y zHow the study uses the data?
The study is based on nizatidine and montelukast sodium (the active ingredients of Axid and Singulair, respectively). Other drugs that have the same active ingredients (e.g. generic drugs or brand names) are also considered. Dosage of drugs is not considered in the study.
Who is eHealthMe?
With medical big data and proven AI algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 600+ medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).
WARNING, DISCLAIMER, USE FOR PUBLICATION
WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.
DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.
If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.
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