Clozapine vs. Olanzapine: side effect and effectiveness comparison - a phase IV clinical study

Summary:

We compare the side effects and drug effectiveness of Clozapine and Olanzapine. The phase IV clinical study is created by eHealthMe based on reports (from sources including the FDA) of 210,479 people who take Clozapine and Olanzapine, and is updated regularly. You can use the study as a second opinion to make health care decisions.

With medical big data and AI algorithms, eHealthMe enables everyone to run phase IV clinical trial to detect adverse drug outcomes and monitor effectiveness. Our original studies have been referenced on 600+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Most recently, phase IV clinial trails for COVID 19 vaccines have been added, check here.

On May, 09, 2022

210,479 people who take Clozapine and Olanzapine are studied.

What is Clozapine?

Clozapine has active ingredients of clozapine. It is often used in schizophrenia. eHealthMe is studying from 55,281 Clozapine users for its effectiveness, alternative drugs and more.

What is Olanzapine?

Olanzapine has active ingredients of olanzapine. It is often used in bipolar disorder. eHealthMe is studying from 48,438 Olanzapine users for its effectiveness, alternative drugs and more.

Number of reports submitted per year:

Clozapine vs Olanzapine drug comparison reports.

Drugs being compared in this study:

Clozapine (clozapine)
Olanzapine (olanzapine)

Most common side effects of the drugs, overall:

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Most common side effects of the drugs, in long term (1+ years) use:

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Drug effectiveness:

Clozapine:

not at all: 3.31 %
somewhat: 26.1 %
moderate: 27.21 %
high: 30.51 %
very high: 12.87 %

Olanzapine:

not at all: 7.3 %
somewhat: 25.1 %
moderate: 33.54 %
high: 23.56 %
very high: 10.49 %

Want to compare Clozapine with Olanzapine?

Personalize this study to your gender and age (0-99+).

How to use the study?

You can discuss the study with your doctor, to ensure that all drug risks and benefits are fully discussed and understood.

Related publications that referenced our studies

Grover S, Sahoo S, "Clozapine induced akathisia: A case report and review of the evidence", Indian journal of pharmacology, 2015 Jan .
Yaylaci S, Yilmaz EU, Guclu E, Kumsar NA, Tamer A, Karabay O, "Clozapine-Induced Febrile Neutropenia and Cellulitis", Turkish journal of emergency medicine, 2014 Mar .
Gupta SK, Shwetank B, "Reversible bilateral sensori-neural hearing loss due to olanzapine in a male suffering from bipolar affective disorder", Indian journal of pharmacology, 2014 Jan .
Og?odek E, Szota A, Araszkiewicz A, "Olanzapine-induced neuroleptic malignant syndrome after 10 years of treatment", Aust NZJ Psychiatry, 2013 Oct .

Related studies

Alternative drugs to, pros and cons of:

Clozapine (54,982 reports)
Olanzapine (47,897 reports)

Common Clozapine side effects:

Abdominal distension: 326 reports
Abdominal pain: 554 reports
Abdominal pain upper: 164 reports
Abnormal behavior: 546 reports
Abnormal dreams: 198 reports
Acute kidney failure: 245 reports
Acute respiratory failure: 118 reports
Acute upper airway obstruction (blockage occurs in the upper airway): 187 reports
Adverse drug reaction: 259 reports
Adverse event: 122 reports
Aggression: 621 reports
Agitation (state of anxiety or nervous excitement): 1,208 reports
Agranulocytosis (a deficiency of granulocytes in the blood, causing increased vulnerability to infection): 9,357 reports
Akathisia (a movement disorder characterized by a feeling of inner restlessness): 397 reports
Alanine aminotransferase increased: 328 reports
Anaemia (lack of blood): 401 reports
Anosognosia (ignorance of the presence of disease): 356 reports
Antipsychotic drug level increased: 554 reports
Apathy: 168 reports
Appetite - decreased (decreased appetite occurs when you have a reduced desire to eat): 373 reports
Appetite - increased (increased appetite is when you want to eat much more often or in larger quantities than your body requires): 208 reports
Arrhythmias (irregular heartbeat): 1,296 reports
Aspartate aminotransferase increased: 193 reports
Aspiration: 221 reports
Asthma: 141 reports
Atrial fibrillation/flutter (atrial fibrillation and flutter are abnormal heart rhythms in which the atria, or upper chambers of the heart, are out of sync with the ventricles): 160 reports
Back pain: 214 reports
Balance disorder: 231 reports
Bedwetting: 162 reports
Blood alkaline phosphatase increased: 215 reports
Blood creatine phosphokinase increased: 530 reports
Blood creatinine increased: 218 reports
Blood glucose increased: 616 reports
Blood urea increased: 122 reports
Body temperature increased: 222 reports
Bradykinesia (decreased bodily movement. it is associated with basal ganglia diseases): 231 reports
Breast cancer: 132 reports
Breathing difficulty: 791 reports
Breathing - slowed or stopped: 133 reports
Cardiac arrest: 635 reports
Cardiac disorder: 311 reports
Cardiac failure: 289 reports
Cardiac failure congestive: 225 reports
Cardiomyopathy (weakening of the heart muscle): 230 reports
Cardio-respiratory arrest (sudden dysfunction of heart and lungs): 258 reports
Catatonia (unresponsive to external stimuli): 425 reports
Cellulitis (infection under the skin): 103 reports
Chest pain: 506 reports
Chills (felling of cold): 146 reports
Chronic obstructive pulmonary disease (a progressive disease that makes it hard to breathe): 246 reports
Circulatory collapse: 293 reports
Cognitive disorder (mental health disorders affects learning, memory, perception, and problem solving): 396 reports
Colitis ischaemic (due to infection of intestine impaired blood supply to colon): 149 reports
Completed suicide (act of taking one's own life): 517 reports
Condition: 593 reports
Confusion: 352 reports
Confusional state: 1,042 reports
Congestive cardiomyopathy (weakening of heart muscle): 125 reports
Consciousness - decreased: 405 reports
Constipation: 1,110 reports
Convulsion (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled shaking of the body): 425 reports
Convulsions (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled of muscles contract and relax rapidly and repeatedly): 115 reports
Cough: 263 reports
C-reactive protein increased: 593 reports
Death: 5,207 reports
Deep venous thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis): 135 reports
Dehydration (dryness resulting from the removal of water): 382 reports
Delirium (wild excitement): 576 reports
Delusion (a false belief or opinion): 587 reports
Dementia (madness): 258 reports
Depressed level of consciousness: 339 reports
Depressed mood: 203 reports
Depression: 512 reports
Diabetes: 471 reports
Diabetic ketoacidosis (diabetic ketoacidosis (dka) is high concentrations of ketone bodies): 157 reports
Diarrhea: 661 reports
Disinhibition (loss of inhibition): 182 reports
Disturbance in attention: 337 reports
Disturbance in social behavior: 363 reports
Dizziness: 750 reports
Drooling (drop saliva uncontrollably from the mouth): 234 reports
Drowsiness: 1,256 reports
Drug abuse and dependence: 323 reports
Drug hypersensitivity: 108 reports
Drug ineffective: 2,080 reports
Drug intolerance (drug sensitivity): 161 reports
Drug level increased: 552 reports
Drug toxicity: 255 reports
Drug withdrawal syndrome (interfere with normal social, occupational, or other functioning. are not due to another medical condition, drug use, or discontinuation): 164 reports
Dry mouth: 115 reports
Dyskinesia (abnormality or impairment of voluntary movement): 961 reports
Ejection fraction decreased (systolic heart failure): 109 reports
Electrocardiogram qt prolonged: 553 reports
Encephalopathy (functioning of the brain is affected by some agent or condition): 130 reports
Enlarged heart: 133 reports
Eosinophil count increased: 160 reports
Eosinophilia (eosinophil count in the peripheral blood exceeds): 304 reports
Epilepsy (common and diverse set of chronic neurological disorders characterized by seizures): 212 reports
Erection problems: 409 reports
Euphoric mood (excessively happy but may become angry or irritable): 154 reports
Extrapyramidal disorder (involuntary muscle spasms in the face and neck): 367 reports
Faecaloma (hard mass of fecal matter): 254 reports
Fainting (loss of consciousness and postural tone): 316 reports
Fall: 1,242 reports
Fatigue (feeling of tiredness): 1,156 reports
Fear: 142 reports
Fever: 1,592 reports
Foetal exposure during pregnancy (exposing your unborn child to contraindicated in pregnancy leads birth defect): 229 reports
Freezing phenomenon: 246 reports
Gait disturbance: 575 reports
Gamma-glutamyltransferase increased: 155 reports
Gastroesophageal reflux disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 102 reports
Gastrointestinal disorder (functional problems of gastrointestinal tract): 115 reports
Gastrointestinal haemorrhage (bleeding gastrointestinal tract): 163 reports
Gastrointestinal hypomotility (less activity of the intestinal tract): 137 reports
General physical health deterioration (weak health status): 513 reports
Grand mal convulsion (a type of generalized seizure that affects the entire brain): 197 reports
Haematemesis (vomiting of blood): 138 reports
Haematocrit decreased: 146 reports
Haemoglobin decreased: 472 reports
Hallucination, auditory (perceiving sounds without auditory stimulus): 556 reports
Hallucinations (sensations that appear real but are created by your mind): 843 reports
Hallucination, visual (seeing things that aren't there): 280 reports
Headache (pain in head): 383 reports
Head injury: 247 reports
Heart attack: 709 reports
Heart palpitations (feelings or sensations that your heart is pounding or racing): 150 reports
Heart rate increased: 350 reports
Hepatic steatosis (fatty liver disease): 115 reports
Hepatitis c: 111 reports
High blood cholesterol: 247 reports
High blood pressure: 646 reports
Hip fracture: 141 reports
Hospitalisation: 5,305 reports
Hyperhidrosis (abnormally increased sweating): 436 reports
Hypokinesia (decreased bodily movement): 119 reports
Hyponatremia (abnormally low level of sodium in the blood; associated with dehydration): 201 reports
Hypophagia (reduced food intake): 130 reports
Hypotension (abnormally low blood pressure): 941 reports
Hypothermia (body temperature drops below the required temperature for normal metabolism and body functions): 200 reports
Ileus paralytic (obstruction of the intestine due to paralysis of the intestinal muscles): 176 reports
Incontinence (lack of moderation or self-control): 107 reports
Infection: 431 reports
Inflammation: 174 reports
Influenza like illness: 220 reports
Insomnia (sleeplessness): 525 reports
Intentional overdose: 188 reports
Intentional self-injury: 172 reports
Intestinal ischaemia (decreased supply of oxygenated blood to the intestines): 105 reports
Intestinal obstruction: 499 reports
Irritability: 162 reports
Itching: 110 reports
Joint pain: 137 reports
Left ventricular dysfunction: 113 reports
Left ventricular hypertrophy (the thickening of the myocardium (muscle) of the left ventricle of the heart): 110 reports
Leukocytosis (increased white blood cells): 348 reports
Leukopenia (less number of white blood cells in blood): 1,565 reports
Loss of consciousness: 596 reports
Lower respiratory tract infection: 296 reports
Lung disorder (lung disease): 130 reports
Lung neoplasm malignant (cancer tumour of lung): 232 reports
Lymphocyte count decreased: 153 reports
Malaise (a feeling of general discomfort or uneasiness): 1,052 reports
Mania (a state of abnormally elevated or irritable mood): 190 reports
Maternal exposure during pregnancy (use of substance during pregnancy): 108 reports
Memory loss: 491 reports
Mental disorder (a psychological term for a mental or behavioural pattern or anomaly that causes distress or disability): 369 reports
Mental impairment (a condition affecting the body, perhaps through sight or hearing loss, a mobility difficulty or a health condition): 418 reports
Mental status changes (general changes in brain function, such as confusion, amnesia (memory loss), loss of alertness, loss of orientation): 251 reports
Metabolic acidosis (body produces too much acid, or when the kidneys are not removing enough acid from the body): 180 reports
Metabolic disorder (an abnormal function and pattern of body fat. insulin resistance refers to the diminished ability of cells to respond to the action of insulin in promoting the transport of the sugar glucose, from blood into muscles and other tissues): 296 reports
Mobility decreased (ability to move is reduced): 233 reports
Mood swings (an extreme or rapid change in mood): 126 reports
Movement disorder (neurological syndromes where they may be excess of movement or a paucity of movement that is not connected to weakness): 111 reports
Movement - uncontrolled or slow: 716 reports
Multi-organ failure (multisystem organ failure): 117 reports
Muscle aches (muscle pain): 184 reports
Muscle rigidity (muscle stiffness): 465 reports
Muscle spasms (muscle contraction): 208 reports
Musculoskeletal stiffness (stiffness of the body's muscles, joints, tendons, ligaments and nerves): 331 reports
Myocarditis (inflammation of heart muscle myocardium): 802 reports
Myoclonus (a brief, involuntary twitching of a muscle or a group of muscles): 272 reports
Nausea (feeling of having an urge to vomit): 743 reports
Nausea and vomiting: 960 reports
Neoplasm malignant (cancer tumour): 237 reports
Neuroleptic malignant syndrome (a life-threatening neurological disorder most often caused by an adverse reaction to neuroleptic or antipsychotic agents): 921 reports
Neutrophil count decreased (less than normal number of neutrophil a type of blood cell): 903 reports
Neutrophil count increased (excess than normal number of neutrophil a type of blood cell): 875 reports
Neutrophilia: 1,210 reports
Obsessive-compulsive disorder (an anxiety disorder characterized by intrusive thoughts that produce uneasiness, apprehension, fear, or worry;): 384 reports
Oculogyric crisis (a spasmodic movement of the eyeballs into a fixed position due to medicine reaction): 116 reports
Oedema peripheral (superficial swelling): 169 reports
On and off phenomenon: 344 reports
Oropharyngeal pain: 125 reports
Orthostatic hypotension (a medical condition consisting of a sudden decrease in blood pressure when a person stands up): 339 reports
Overdose: 808 reports
Oxygen saturation decreased: 117 reports
Pain: 331 reports
Pain in extremity: 226 reports
Paleness (unusual lightness of skin colour): 112 reports
Pancreatitis (inflammation of pancreas): 232 reports
Pancytopenia (medical condition in which there is a reduction in the number of red and white blood cells, as well as platelets): 109 reports
Paraesthesia (sensation of tingling, tickling, prickling, pricking, or burning of a person's skin with no apparent long-term physical effect): 112 reports
Paranoia (psychotic disorder characterized by delusions of persecution with or without grandeur): 326 reports
Parkinson's disease: 611 reports
Pericardial effusion (fluid around the heart): 268 reports
Pericarditis (inflammation of the pericardium): 214 reports
Persecutory delusion: 115 reports
Personality change: 327 reports
Personality disorder: 227 reports
Platelet count increased: 154 reports
Pleural effusion (water on the lungs): 267 reports
Pneumonia: 1,647 reports
Pneumonia aspiration (bronchopneumonia that develops due to the entrance of foreign materials into the bronchial tree): 471 reports
Pre-existing disease: 103 reports
Psychiatric decompensation (worsening of symptoms to the state of a serious mental disorder): 169 reports
Psychiatric symptom: 131 reports
Psychomotor hyperactivity (feelings of extreme restlessness): 147 reports
Psychotic disorder: 1,521 reports
Pulmonary embolism (blockage of the main artery of the lung): 492 reports
Pulmonary oedema (fluid accumulation in the lungs): 243 reports
Rashes (redness): 277 reports
Red blood cell count decreased: 133 reports
Red blood cell sedimentation rate increased: 105 reports
Renal failure acute (rapid kidney dysfunction): 189 reports
Renal impairment (severely reduced kidney function): 168 reports
Respiratory acidosis (respiratory failure or ventilatory failure, causes the ph of blood and other bodily fluids to decrease): 370 reports
Respiratory disorder (respiratory disease): 136 reports
Respiratory distress (difficulty in breathing): 163 reports
Rhabdomyolysis (a condition in which damaged skeletal muscle tissue breaks down): 277 reports
Salivary hypersecretion (excess saliva secretion): 879 reports
Schizoaffective disorder (a mental disorder characterized by disordered thought): 162 reports
Schizophrenia (a mental disorder characterized by a breakdown of thought processes): 1,068 reports
Sedation: 1,104 reports
Seizures (abnormal excessive or synchronous neuronal activity in the brain): 356 reports
Sepsis (a severe blood infection that can lead to organ failure and death): 577 reports
Septic shock (shock due to blood infection): 190 reports
Serotonin syndrome (occurs when two drugs that affect the body's level of serotonin are taken together at the same time): 110 reports
Shock (a life-threatening condition with symptoms like low blood pressure, weakness, shallow breathing, cold, clammy skin): 141 reports
Sinus tachycardia (a heart rhythm with elevated rate of impulses originating from the sinoatrial node): 384 reports
Sleep disorder: 258 reports
Small intestinal obstruction (blockage in small intestine): 107 reports
Sopor (sleep): 275 reports
Speech disorder: 388 reports
Speech impairment (adult) (inability to speak (adult)): 435 reports
Stress and anxiety: 847 reports
Stroke (sudden death of a portion of the brain cells due to a lack of oxygen): 294 reports
Suicidal ideation: 486 reports
Suicide attempt: 896 reports
Swallowing difficulty: 432 reports
Tachypnea: 109 reports
Tardive dyskinesia (a disorder that involves involuntary movements): 283 reports
The flu (the flu is caused by an influenza virus): 137 reports
Therapeutic response decreased (less preventive response): 137 reports
Thrombocytopenia (decrease of platelets in blood): 667 reports
Tremor (trembling or shaking movements in one or more parts of your body): 615 reports
Troponin increased: 225 reports
Type 2 diabetes: 180 reports
Unevaluable reaction: 101 reports
Unresponsive to stimuli: 216 reports
Upper respiratory tract infection: 105 reports
Urinary incontinence (inability to control the flow of urine and involuntary urination): 329 reports
Urinary retention (the inability to completely or partially empty the bladder): 122 reports
Urinary tract infection: 748 reports
Urination - excessive at night: 116 reports
Viral infection: 106 reports
Vision blurred: 125 reports
Visual impairment: 120 reports
Weakness: 733 reports
Weight decreased: 674 reports
Weight increased: 1,028 reports
Weight loss: 300 reports
White blood cell count decreased: 1,100 reports
White blood cell count increased: 1,079 reports
Withdrawal syndrome (a discontinuation syndrome is a set of symptoms occurred due to discontinuation of substance): 192 reports

Common Olanzapine side effects:

Abdominal discomfort: 192 reports
Abdominal distension: 241 reports
Abdominal pain: 539 reports
Abdominal pain upper: 285 reports
Abnormal behavior: 605 reports
Abnormal weight gain: 113 reports
Accidental overdose (therapeutic agent): 178 reports
Acute hepatic failure: 106 reports
Acute kidney failure: 366 reports
Acute myocardial infarction (acute heart attack): 110 reports
Acute psychosis (period of mentally unstable behaviour): 108 reports
Acute respiratory failure: 121 reports
Adverse drug reaction: 254 reports
Adverse event: 120 reports
Aggression: 1,072 reports
Agitation (state of anxiety or nervous excitement): 2,095 reports
Agranulocytosis (a deficiency of granulocytes in the blood, causing increased vulnerability to infection): 1,654 reports
Akathisia (a movement disorder characterized by a feeling of inner restlessness): 763 reports
Alanine aminotransferase increased: 509 reports
Alcoholism (problems with alcohol): 135 reports
Altered state of consciousness (altered state of mind): 223 reports
Anaemia (lack of blood): 515 reports
Anger: 168 reports
Anosognosia (ignorance of the presence of disease): 341 reports
Antipsychotic drug level increased: 163 reports
Apathy: 207 reports
Appetite - decreased (decreased appetite occurs when you have a reduced desire to eat): 576 reports
Appetite - increased (increased appetite is when you want to eat much more often or in larger quantities than your body requires): 418 reports
Ards (acute respiratory distress syndrome) (sudden failure of the respiratory (breathing) system): 115 reports
Arrhythmias (irregular heartbeat): 1,525 reports
Aspartate aminotransferase increased: 369 reports
Asthma: 124 reports
Atrial fibrillation/flutter (atrial fibrillation and flutter are abnormal heart rhythms in which the atria, or upper chambers of the heart, are out of sync with the ventricles): 227 reports
Back pain: 274 reports
Balance disorder: 372 reports
Bipolar disorder (mood disorder): 246 reports
Blood alkaline phosphatase increased: 176 reports
Blood bilirubin increased: 185 reports
Blood creatine phosphokinase increased: 733 reports
Blood creatinine increased: 247 reports
Blood glucose increased: 679 reports
Blood lactate dehydrogenase increased: 146 reports
Blood pressure fluctuation: 106 reports
Blood prolactin increased: 210 reports
Blood sodium decreased: 135 reports
Body temperature increased: 196 reports
Bradycardia (abnormally slow heart action): 432 reports
Bradykinesia (decreased bodily movement. it is associated with basal ganglia diseases): 111 reports
Bradyphrenia (neurological term referring to the slowness of thought common to many disorders of the brain): 172 reports
Brain oedema (excess accumulation of fluid in the intracellular or extracellular spaces of the brain): 145 reports
Breathing difficulty: 1,103 reports
Breathing - slowed or stopped: 360 reports
Bronchitis (inflammation of the mucous membrane in the bronchial tubes): 166 reports
Cardiac arrest: 681 reports
Cardiac disorder: 157 reports
Cardiac failure: 195 reports
Cardiomyopathy (weakening of the heart muscle): 192 reports
Cardio-respiratory arrest (sudden dysfunction of heart and lungs): 526 reports
Catatonia (unresponsive to external stimuli): 499 reports
Cellulitis (infection under the skin): 136 reports
Chest pain: 722 reports
Chills (felling of cold): 226 reports
Chronic kidney disease: 158 reports
Chronic obstructive pulmonary disease (a progressive disease that makes it hard to breathe): 144 reports
Circulatory collapse: 178 reports
Cognitive disorder (mental health disorders affects learning, memory, perception, and problem solving): 430 reports
Colitis ischaemic (due to infection of intestine impaired blood supply to colon): 110 reports
Completed suicide (act of taking one's own life): 1,748 reports
Condition: 809 reports
Confusion: 646 reports
Confusional state: 1,698 reports
Consciousness - decreased: 962 reports
Constipation: 841 reports
Convulsion (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled shaking of the body): 309 reports
Cough: 399 reports
C-reactive protein increased: 340 reports
Crying: 132 reports
Death: 1,253 reports
Deep venous thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis): 386 reports
Dehydration (dryness resulting from the removal of water): 570 reports
Delirium (wild excitement): 830 reports
Delusion (a false belief or opinion): 751 reports
Dementia (madness): 146 reports
Depressed level of consciousness: 825 reports
Depressed mood: 360 reports
Depression: 1,335 reports
Diabetes: 502 reports
Diabetic ketoacidosis (diabetic ketoacidosis (dka) is high concentrations of ketone bodies): 316 reports
Diarrhea: 976 reports
Discomfort: 117 reports
Disease progression: 119 reports
Disease recurrence: 177 reports
Disinhibition (loss of inhibition): 164 reports
Disturbance in attention: 439 reports
Disturbance in social behavior: 354 reports
Dizziness: 1,267 reports
Drooling (drop saliva uncontrollably from the mouth): 124 reports
Drowsiness: 2,002 reports
Drug abuse and dependence: 1,248 reports
Drug dependence: 171 reports
Drug exposure during pregnancy: 179 reports
Drug hypersensitivity: 195 reports
Drug-induced liver injury (diseases of the liver that are caused by physician-prescribed medications): 222 reports
Drug ineffective: 3,353 reports
Drug intolerance (drug sensitivity): 215 reports
Drug level decreased: 102 reports
Drug level increased: 267 reports
Drug resistance (reduction in effectiveness of a drug): 214 reports
Drug toxicity: 286 reports
Drug withdrawal syndrome (interfere with normal social, occupational, or other functioning. are not due to another medical condition, drug use, or discontinuation): 261 reports
Drug withdrawal syndrome neonatal (prenatal nas is caused by discontinuation of drugs taken by the pregnant mother): 102 reports
Dry mouth: 293 reports
Dyskinesia (abnormality or impairment of voluntary movement): 759 reports
Dyslipidaemia (abnormal amount of lipids): 136 reports
Eating disorder: 166 reports
Ejection fraction decreased (systolic heart failure): 127 reports
Electrocardiogram qt prolonged: 1,175 reports
Emotional distress: 251 reports
Encephalopathy (functioning of the brain is affected by some agent or condition): 150 reports
Eosinophil count increased: 127 reports
Eosinophilia (eosinophil count in the peripheral blood exceeds): 180 reports
Epilepsy (common and diverse set of chronic neurological disorders characterized by seizures): 213 reports
Erection problems: 547 reports
Erythema multiforme (a type of hypersensitivity reaction): 147 reports
Euphoric mood (excessively happy but may become angry or irritable): 215 reports
Extrapyramidal disorder (involuntary muscle spasms in the face and neck): 793 reports
Fainting (loss of consciousness and postural tone): 444 reports
Fall: 1,307 reports
Fatigue (feeling of tiredness): 1,710 reports
Fear: 120 reports
Febrile neutropenia (fever with reduced white blood cells): 248 reports
Feeling cold: 114 reports
Fever: 1,628 reports
Fluid retention (an abnormal accumulation of fluid in the blood): 115 reports
Foetal exposure during pregnancy (exposing your unborn child to contraindicated in pregnancy leads birth defect): 518 reports
Gait disturbance: 724 reports
Gallstones (stone formation by bile component): 154 reports
Gamma-glutamyltransferase increased: 216 reports
Gastroesophageal reflux disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 189 reports
Gastrointestinal disorder (functional problems of gastrointestinal tract): 149 reports
Gastrointestinal haemorrhage (bleeding gastrointestinal tract): 133 reports
General physical health deterioration (weak health status): 409 reports
Gestational diabetes (diabetes in pregnancy): 182 reports
Grand mal convulsion (a type of generalized seizure that affects the entire brain): 160 reports
Gynecomastia (enlargement of the gland tissue of the male breast): 112 reports
Haematemesis (vomiting of blood): 110 reports
Haematocrit decreased: 168 reports
Haemoglobin decreased: 408 reports
Haemorrhage (bleeding): 122 reports
Hair loss: 167 reports
Hallucination, auditory (perceiving sounds without auditory stimulus): 699 reports
Hallucinations (sensations that appear real but are created by your mind): 715 reports
Hallucination, visual (seeing things that aren't there): 270 reports
Headache (pain in head): 837 reports
Head injury: 424 reports
Heart attack: 315 reports
Heart palpitations (feelings or sensations that your heart is pounding or racing): 275 reports
Heart rate increased: 421 reports
Hepatic enzyme increased: 278 reports
Hepatic failure (liver failure): 110 reports
Hepatic steatosis (fatty liver disease): 163 reports
Hepatitis (inflammation of the liver): 135 reports
Hepatocellular injury (liver injury): 193 reports
Hepatotoxicity (chemical-driven liver damage): 133 reports
High blood cholesterol: 457 reports
High blood pressure: 1,012 reports
Hospitalisation: 291 reports
Hyperammonaemia: 112 reports
Hyperglycemia (high blood sugar): 260 reports
Hyperhidrosis (abnormally increased sweating): 615 reports
Hyperkalemia (damage to or disease of the kidney): 186 reports
Hypernatraemia (an abnormally high plasma concentration of sodium ions): 107 reports
Hyperprolactinaemia (abnormally high levels of prolactin in the blood): 319 reports
Hypersensitivity: 183 reports
Hypoaesthesia (reduced sense of touch or sensation): 216 reports
Hypocalcaemia (levels of calcium in blood serum are abnormally low): 115 reports
Hypoglycemia (low blood sugar): 339 reports
Hypokalemia (low potassium): 266 reports
Hypokinesia (decreased bodily movement): 152 reports
Hypomania (a mild form of mania, marked by elation and hyperactivity): 233 reports
Hyponatremia (abnormally low level of sodium in the blood; associated with dehydration): 708 reports
Hypophagia (reduced food intake): 153 reports
Hypotension (abnormally low blood pressure): 1,635 reports
Hypothermia (body temperature drops below the required temperature for normal metabolism and body functions): 536 reports
Hypothyroidism (abnormally low activity of the thyroid gland, resulting in retardation of growth and mental development): 149 reports
Hypotonia (low muscle tone): 119 reports
Inappropriate antidiuretic hormone secretion: 175 reports
Indigestion: 120 reports
Infection: 185 reports
Influenza like illness: 144 reports
Injury: 102 reports
Insomnia (sleeplessness): 1,191 reports
Intentional overdose: 1,144 reports
Intentional self-injury: 920 reports
Intestinal obstruction: 212 reports
Irritability: 466 reports
Itching: 293 reports
Jaundice cholestatic: 103 reports
Joint pain: 263 reports
Joint swelling: 157 reports
Leukocytosis (increased white blood cells): 186 reports
Leukopenia (less number of white blood cells in blood): 668 reports
Liver disorder (liver diseases): 129 reports
Loss of consciousness: 715 reports
Lower respiratory tract infection: 236 reports
Lymphocyte count decreased: 158 reports
Malaise (a feeling of general discomfort or uneasiness): 1,105 reports
Malignant neoplasm progression (cancer tumour came back): 105 reports
Mania (a state of abnormally elevated or irritable mood): 616 reports
Maternal exposure during pregnancy (use of substance during pregnancy): 211 reports
Memory loss: 769 reports
Mental disorder (a psychological term for a mental or behavioural pattern or anomaly that causes distress or disability): 424 reports
Mental impairment (a condition affecting the body, perhaps through sight or hearing loss, a mobility difficulty or a health condition): 541 reports
Mental status changes (general changes in brain function, such as confusion, amnesia (memory loss), loss of alertness, loss of orientation): 364 reports
Metabolic acidosis (body produces too much acid, or when the kidneys are not removing enough acid from the body): 182 reports
Metabolic disorder (an abnormal function and pattern of body fat. insulin resistance refers to the diminished ability of cells to respond to the action of insulin in promoting the transport of the sugar glucose, from blood into muscles and other tissues): 429 reports
Metabolic syndrome (a combination of the medical disorders that, when occurring together, increase the risk of developing cardiovascular disease): 113 reports
Miosis (constriction of the pupil of the eye, resulting from a normal response to an increase in light): 263 reports
Mood swings (an extreme or rapid change in mood): 239 reports
Movement disorder (neurological syndromes where they may be excess of movement or a paucity of movement that is not connected to weakness): 143 reports
Movement - uncontrolled or slow: 746 reports
Movement - uncoordinated: 222 reports
Multiple drug overdose: 139 reports
Muscle aches (muscle pain): 269 reports
Muscle rigidity (muscle stiffness): 554 reports
Muscle spasms (muscle contraction): 340 reports
Muscle twitching: 136 reports
Musculoskeletal stiffness (stiffness of the body's muscles, joints, tendons, ligaments and nerves): 343 reports
Mydriasis (a dilation of the pupil): 155 reports
Myocarditis (inflammation of heart muscle myocardium): 423 reports
Myoclonus (a brief, involuntary twitching of a muscle or a group of muscles): 206 reports
Nasopharyngitis (inflammation of the nasopharynx): 165 reports
Nausea (feeling of having an urge to vomit): 1,557 reports
Nausea and vomiting: 1,572 reports
Nervousness: 133 reports
Nervous system disorder (a general class of medical conditions affecting the nervous system): 106 reports
Neuroleptic malignant syndrome (a life-threatening neurological disorder most often caused by an adverse reaction to neuroleptic or antipsychotic agents): 1,688 reports
Neurotoxicity (when the exposure to natural or artificial toxic substances, which are called neurotoxins, alters the normal activity of the nervous system): 110 reports
Neutrophil count decreased (less than normal number of neutrophil a type of blood cell): 449 reports
Neutrophil count increased (excess than normal number of neutrophil a type of blood cell): 252 reports
Nightmares (unpleasant dreams): 121 reports
Non-accidental overdose: 102 reports
Nosebleed (bleeding from nose): 171 reports
Obsessive-compulsive disorder (an anxiety disorder characterized by intrusive thoughts that produce uneasiness, apprehension, fear, or worry;): 290 reports
Oculogyric crisis (a spasmodic movement of the eyeballs into a fixed position due to medicine reaction): 242 reports
Oedema (fluid collection in tissue): 150 reports
Oedema peripheral (superficial swelling): 425 reports
Oropharyngeal pain: 160 reports
Orthostatic hypotension (a medical condition consisting of a sudden decrease in blood pressure when a person stands up): 203 reports
Overdose: 1,889 reports
Oxygen saturation decreased: 243 reports
Pain: 634 reports
Pain in extremity: 372 reports
Paleness (unusual lightness of skin colour): 151 reports
Pancreatitis (inflammation of pancreas): 190 reports
Pancytopenia (medical condition in which there is a reduction in the number of red and white blood cells, as well as platelets): 253 reports
Panic disorder: 196 reports
Paraesthesia (sensation of tingling, tickling, prickling, pricking, or burning of a person's skin with no apparent long-term physical effect): 276 reports
Paranoia (psychotic disorder characterized by delusions of persecution with or without grandeur): 393 reports
Parkinson's disease: 643 reports
Penis pain: 180 reports
Pericardial effusion (fluid around the heart): 136 reports
Pericarditis (inflammation of the pericardium): 103 reports
Peripheral swelling: 260 reports
Persecutory delusion: 174 reports
Personality change: 355 reports
Pleural effusion (water on the lungs): 215 reports
Pneumonia: 1,282 reports
Pneumonia aspiration (bronchopneumonia that develops due to the entrance of foreign materials into the bronchial tree): 468 reports
Poisoning: 212 reports
Pollakiuria (abnormally frequent passage of relatively small quantities or urine): 112 reports
Poor quality sleep: 107 reports
Prescribed overdose: 210 reports
Productive cough: 117 reports
Psychiatric decompensation (worsening of symptoms to the state of a serious mental disorder): 102 reports
Psychiatric symptom: 143 reports
Psychomotor hyperactivity (feelings of extreme restlessness): 303 reports
Psychotic disorder: 1,513 reports
Pulmonary congestion (congestion in the lungs): 146 reports
Pulmonary embolism (blockage of the main artery of the lung): 711 reports
Pulmonary oedema (fluid accumulation in the lungs): 253 reports
Rashes (redness): 788 reports
Rash maculo-papular (red area on the skin that is covered with small confluent bumps): 102 reports
Red blood cell count decreased: 158 reports
Renal failure acute (rapid kidney dysfunction): 245 reports
Renal impairment (severely reduced kidney function): 192 reports
Respiratory acidosis (respiratory failure or ventilatory failure, causes the ph of blood and other bodily fluids to decrease): 442 reports
Respiratory depression (respiration has a rate below 12 breaths): 284 reports
Respiratory disorder (respiratory disease): 102 reports
Respiratory distress (difficulty in breathing): 199 reports
Restless leg syndrome (a powerful urge to move your legs): 144 reports
Rhabdomyolysis (a condition in which damaged skeletal muscle tissue breaks down): 613 reports
Salivary hypersecretion (excess saliva secretion): 499 reports
Schizoaffective disorder (a mental disorder characterized by disordered thought): 164 reports
Schizophrenia (a mental disorder characterized by a breakdown of thought processes): 1,223 reports
Screaming (a long loud piercing cry): 102 reports
Sedation: 1,463 reports
Seizures (abnormal excessive or synchronous neuronal activity in the brain): 624 reports
Sepsis (a severe blood infection that can lead to organ failure and death): 590 reports
Septic shock (shock due to blood infection): 198 reports
Serotonin syndrome (occurs when two drugs that affect the body's level of serotonin are taken together at the same time): 457 reports
Shock (a life-threatening condition with symptoms like low blood pressure, weakness, shallow breathing, cold, clammy skin): 138 reports
Sinus tachycardia (a heart rhythm with elevated rate of impulses originating from the sinoatrial node): 302 reports
Skin discoloration - bluish (bluish colour of skin): 108 reports
Sleep disorder: 272 reports
Social avoidant behavior: 252 reports
Sopor (sleep): 766 reports
Speech disorder: 512 reports
Speech impairment (adult) (inability to speak (adult)): 857 reports
Stress and anxiety: 1,629 reports
Stroke (sudden death of a portion of the brain cells due to a lack of oxygen): 249 reports
Stupor (lack of critical cognitive function and level of consciousness): 103 reports
Sudden cardiac death: 106 reports
Suicidal ideation: 1,112 reports
Suicide attempt: 1,722 reports
Swallowing difficulty: 491 reports
Swelling: 109 reports
Swelling face: 134 reports
Tachypnea: 165 reports
Tardive dyskinesia (a disorder that involves involuntary movements): 425 reports
The flu (the flu is caused by an influenza virus): 125 reports
Therapeutic response decreased (less preventive response): 208 reports
Thirst: 114 reports
Thirst - excessive: 163 reports
Thrombocytopenia (decrease of platelets in blood): 967 reports
Tinnitus (a ringing in the ears): 114 reports
Torsade de pointes (a abnormal heart rate with abnormal beating pattern): 162 reports
Transaminases increased: 181 reports
Tremor (trembling or shaking movements in one or more parts of your body): 1,216 reports
Troponin increased: 125 reports
Type 2 diabetes: 245 reports
Unresponsive to stimuli: 412 reports
Urinary incontinence (inability to control the flow of urine and involuntary urination): 279 reports
Urinary retention (the inability to completely or partially empty the bladder): 297 reports
Urinary tract infection: 479 reports
Urination - excessive volume: 142 reports
Urination - painful: 131 reports
Ventricular tachycardia (rapid heartbeat that originates in one of the lower chambers (the ventricles) of the heart): 107 reports
Vision blurred: 325 reports
Visual impairment: 130 reports
Weakness: 1,199 reports
Weight decreased: 746 reports
Weight increased: 1,992 reports
Weight loss: 293 reports
White blood cell count decreased: 782 reports
White blood cell count increased: 436 reports
Withdrawal syndrome (a discontinuation syndrome is a set of symptoms occurred due to discontinuation of substance): 285 reports

How the study uses the data?

The study is based on clozapine and olanzapine (the active ingredients of Clozapine and Olanzapine, respectively). Other drugs that have the same active ingredients (e.g. generic drugs or brand names) are also considered. Dosage of drugs is not considered in the study.

Who is eHealthMe?

With medical big data and proven AI algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 600+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

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