Concerta vs. Depakote: side effect and effectiveness comparison - a phase IV clinical study
Summary:
We compare the side effects and drug effectiveness of Concerta and Depakote. The phase IV clinical study is created by eHealthMe based on reports (from sources including the FDA) of 123,348 people who take Concerta and Depakote, and is updated regularly. You can use the study as a second opinion to make health care decisions.
Phase IV trials are used to detect adverse drug outcomes and monitor drug effectiveness in the real world. With medical big data and AI algorithms, eHealthMe is running millions of phase IV trials and makes the results available to the public. Our original studies have been referenced on 600+ medical publications including The Lancet, Mayo Clinic Proceedings, and Nature.
On Jun, 18, 2022
123,348 people who take Concerta and Depakote are studied.
What is Concerta?
Concerta has active ingredients of methylphenidate hydrochloride. It is often used in attention deficit hyperactivity disorder. eHealthMe is studying from 20,906 Concerta users for its effectiveness, alternative drugs and more.
What is Depakote?
Depakote has active ingredients of divalproex sodium. It is often used in bipolar disorder. eHealthMe is studying from 50,780 Depakote users for its effectiveness, alternative drugs and more.
Number of reports submitted per year:
Drugs being compared in this study:
- Depakote (divalproex sodium)
- Concerta (methylphenidate hydrochloride)
Most common side effects of the drugs, overall:
Most common side effects of the drugs, in long term (1+ years) use:
Drug effectiveness:
Concerta:
- not at all: 2.31 %
- somewhat: 15.14 %
- moderate: 36.08 %
- high: 34.33 %
- very high: 12.14 %
Depakote:
- not at all: 5.04 %
- somewhat: 20.62 %
- moderate: 31.25 %
- high: 29.71 %
- very high: 13.39 %
Want to compare Concerta with Depakote?
Personalize this study to your gender and age (0-99+).How to use the study?
You can discuss the study with your doctor, to ensure that all drug risks and benefits are fully discussed and understood.
Related publications that referenced our studies
- Coskun M, Adak I, "Excessive and frequent menstrual bleeding with methylphenidate in an adolescent girl with attention-deficit hyperactivity disorder", Journal of clinical psychopharmacology, 2017 Oct .
- Yektas ?, Samurcu ND, Tufan AE, "Loss of Eyebrows (Madarosis) After Use of Long-Acting Methylphenidate: Case Report", Journal of Clinical Psychopharmacology, 2017 Aug .
- Ersoy MA, Ersoy HT, "Manic symptoms associated with isotretinoin and methylphenidate combination: a case report", Klinik Psikofarmakoloji Bülteni-Bulletin of Clinical Psychopharmacology, 2014 Sep .
- Coskun M, Adak I, Akaltun I, "Bilateral gynecomastia in a preadolescent boy while under treatment with methylphenidate and paroxetine", Journal of clinical psychopharmacology, 2014 Aug .
- Adak, I., & Coskun, M. , "Symptomatic cholelithiasis associated with combined use of methylphenidate and fluoxetine in an otherwise healthy adolescent girl", Psychiatry and Clinical Psychopharmacology, 2014 Jan .
- Coskun, M., & Adak, I. , "Excessive and frequent menstrual bleeding with methylphenidate in an adolescent girl with attention-deficit hyperactivity disorder", Journal of clinical psychopharmacology, 2014 Jan .
- Yalcin O, Aslan AA, Sari BA, Turkbay T, "Possible methylphenidate related hoarseness and disturbances of voice quality: two pediatric cases", Klinik Psikofarmakoloji Bülteni-Bulletin of Clinical Psychopharmacology, 2012 Sep .
- Lufi D, Bucherman M, Akita M, Cohen R, Sibani C, "The effect of methylphenidate on speech patterns of children with attention deficit disorder", Journal of Behavioral Health, 2012 Jan .
Related studies
Alternative drugs to, pros and cons of:
Common Concerta side effects:
- Abdominal discomfort: 104 reports
- Abdominal pain: 298 reports
- Abdominal pain upper: 303 reports
- Abnormal behavior: 493 reports
- Adverse event: 175 reports
- Aggression: 635 reports
- Agitation (state of anxiety or nervous excitement): 525 reports
- Alanine aminotransferase increased: 110 reports
- Anaemia (lack of blood): 108 reports
- Anger: 241 reports
- Anorexia (eating disorder characterized by immoderate food restriction and irrational fear of gaining weight): 127 reports
- Appetite - decreased (decreased appetite occurs when you have a reduced desire to eat): 527 reports
- Appetite - increased (increased appetite is when you want to eat much more often or in larger quantities than your body requires): 135 reports
- Arrhythmias (irregular heartbeat): 407 reports
- Asthma: 132 reports
- Attention deficit hyperactivity disorder (a chronic condition including attention difficulty, hyperactivity, and impulsiveness): 192 reports
- Back pain: 233 reports
- Breathing difficulty: 336 reports
- Chest pain: 426 reports
- Completed suicide (act of taking one's own life): 102 reports
- Condition: 242 reports
- Confusional state: 198 reports
- Constipation: 181 reports
- Convulsion (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled shaking of the body): 193 reports
- Cough: 168 reports
- Crying: 185 reports
- Dehydration (dryness resulting from the removal of water): 114 reports
- Depressed mood: 161 reports
- Depression: 726 reports
- Diabetes: 107 reports
- Diarrhea: 248 reports
- Disturbance in attention: 495 reports
- Dizziness: 545 reports
- Drowsiness: 521 reports
- Drug abuse and dependence: 146 reports
- Drug effect decreased: 232 reports
- Drug ineffective: 1,431 reports
- Dry mouth: 111 reports
- Dyskinesia (abnormality or impairment of voluntary movement): 210 reports
- Electrocardiogram qt prolonged: 111 reports
- Emotional disorder: 139 reports
- Emotional distress: 124 reports
- Fainting (loss of consciousness and postural tone): 187 reports
- Fall: 257 reports
- Fatigue (feeling of tiredness): 815 reports
- Fever: 324 reports
- Growth retardation (delayed growth): 238 reports
- Gynecomastia (enlargement of the gland tissue of the male breast): 251 reports
- Hair loss: 119 reports
- Hallucination, auditory (perceiving sounds without auditory stimulus): 139 reports
- Hallucinations (sensations that appear real but are created by your mind): 282 reports
- Hallucination, visual (seeing things that aren't there): 141 reports
- Headache (pain in head): 928 reports
- Head injury: 154 reports
- Heart palpitations (feelings or sensations that your heart is pounding or racing): 283 reports
- Heart rate increased: 284 reports
- High blood cholesterol: 122 reports
- High blood pressure: 593 reports
- Hospitalisation: 246 reports
- Hyperhidrosis (abnormally increased sweating): 204 reports
- Hypersensitivity: 132 reports
- Hypoaesthesia (reduced sense of touch or sensation): 149 reports
- Hypotension (abnormally low blood pressure): 154 reports
- Indigestion: 101 reports
- Insomnia (sleeplessness): 665 reports
- Intentional overdose: 121 reports
- Intentional self-injury: 129 reports
- Irritability: 310 reports
- Itching: 225 reports
- Joint pain: 234 reports
- Loss of consciousness: 183 reports
- Malaise (a feeling of general discomfort or uneasiness): 347 reports
- Memory loss: 243 reports
- Migraine (headache): 191 reports
- Mood swings (an extreme or rapid change in mood): 286 reports
- Movement - uncontrolled or slow: 137 reports
- Muscle aches (muscle pain): 120 reports
- Muscle spasms (muscle contraction): 150 reports
- Muscle twitching: 113 reports
- Nasopharyngitis (inflammation of the nasopharynx): 191 reports
- Nausea (feeling of having an urge to vomit): 783 reports
- Nausea and vomiting: 519 reports
- Nervousness: 122 reports
- Overdose: 291 reports
- Pain: 449 reports
- Pain in extremity: 199 reports
- Panic disorder: 124 reports
- Paraesthesia (sensation of tingling, tickling, prickling, pricking, or burning of a person's skin with no apparent long-term physical effect): 131 reports
- Paranoia (psychotic disorder characterized by delusions of persecution with or without grandeur): 120 reports
- Pneumonia: 130 reports
- Psychomotor hyperactivity (feelings of extreme restlessness): 243 reports
- Psychotic disorder: 264 reports
- Rashes (redness): 380 reports
- Sinusitis (inflammation of sinus): 126 reports
- Sleep apnea syndrome: 130 reports
- Sleep disorder: 204 reports
- Speech disorder: 119 reports
- Speech impairment (adult) (inability to speak (adult)): 128 reports
- Stress and anxiety: 886 reports
- Suicidal ideation: 656 reports
- Suicide attempt: 354 reports
- Tic (a sudden, repetitive, nonrhythmic motor movement or vocalization involving discrete muscle groups): 268 reports
- Tremor (trembling or shaking movements in one or more parts of your body): 352 reports
- Urinary tract infection: 121 reports
- Urticaria (rash of round, red welts on the skin that itch intensely): 114 reports
- Vision blurred: 211 reports
- Weakness: 342 reports
- Weight decreased: 546 reports
- Weight increased: 440 reports
- Withdrawal syndrome (a discontinuation syndrome is a set of symptoms occurred due to discontinuation of substance): 109 reports
Common Depakote side effects:
- Abasia (inability to walk): 191 reports
- Abdominal discomfort: 311 reports
- Abdominal distension: 263 reports
- Abdominal pain: 821 reports
- Abdominal pain upper: 535 reports
- Abnormal behavior: 824 reports
- Abnormal dreams: 215 reports
- Abortion spontaneous (naturally occurring miscarriage): 124 reports
- Accidental overdose (therapeutic agent): 159 reports
- Acne (skin problems that cause pimples): 110 reports
- Activities of daily living impaired: 355 reports
- Acute kidney failure: 513 reports
- Acute upper airway obstruction (blockage occurs in the upper airway): 108 reports
- Adverse drug reaction: 262 reports
- Adverse event: 242 reports
- Aggression: 1,071 reports
- Agitation (state of anxiety or nervous excitement): 1,346 reports
- Agranulocytosis (a deficiency of granulocytes in the blood, causing increased vulnerability to infection): 1,114 reports
- Akathisia (a movement disorder characterized by a feeling of inner restlessness): 176 reports
- Alanine aminotransferase increased: 321 reports
- Alcoholism (problems with alcohol): 145 reports
- Ammonia increased: 393 reports
- Anaemia (lack of blood): 600 reports
- Anger: 493 reports
- Anhedonia (inability to experience pleasure from activities usually found enjoyable): 744 reports
- Anorexia (eating disorder characterized by immoderate food restriction and irrational fear of gaining weight): 206 reports
- Anticonvulsant drug level decreased: 102 reports
- Apathy: 125 reports
- Appetite - decreased (decreased appetite occurs when you have a reduced desire to eat): 614 reports
- Appetite - increased (increased appetite is when you want to eat much more often or in larger quantities than your body requires): 340 reports
- Ards (acute respiratory distress syndrome) (sudden failure of the respiratory (breathing) system): 105 reports
- Arrhythmias (irregular heartbeat): 508 reports
- Arthritis (form of joint disorder that involves inflammation of one or more joints): 178 reports
- Aspartate aminotransferase increased: 306 reports
- Asthma: 280 reports
- Atrial fibrillation/flutter (atrial fibrillation and flutter are abnormal heart rhythms in which the atria, or upper chambers of the heart, are out of sync with the ventricles): 227 reports
- Atrial septal defect (an abnormal opening between the left and right atria of the heart): 106 reports
- Attention deficit hyperactivity disorder (a chronic condition including attention difficulty, hyperactivity, and impulsiveness): 105 reports
- Back pain: 768 reports
- Balance disorder: 537 reports
- Bipolar disorder (mood disorder): 660 reports
- Bipolar i disorder (mood disorder that is characterized by at least one manic or mixed episode): 175 reports
- Blindness: 107 reports
- Blister (small pocket of fluid within the upper layers of the skin caused by forceful rubbing (friction), burning, freezing, chemical exposure): 148 reports
- Blood creatine phosphokinase increased: 241 reports
- Blood creatinine increased: 171 reports
- Blood glucose decreased: 147 reports
- Blood glucose increased: 528 reports
- Blood potassium decreased: 105 reports
- Blood prolactin increased: 113 reports
- Blood sodium decreased: 128 reports
- Blood urea increased: 163 reports
- Body temperature increased: 108 reports
- Bone pain: 115 reports
- Bradycardia (abnormally slow heart action): 167 reports
- Breathing difficulty: 1,146 reports
- Breathing - slowed or stopped: 105 reports
- Bronchitis (inflammation of the mucous membrane in the bronchial tubes): 310 reports
- Burning sensation: 186 reports
- Cardiac arrest: 291 reports
- Cardiac disorder: 285 reports
- Cardiac failure congestive: 249 reports
- Cardiac murmur (an heart sound in valve abnormality): 110 reports
- Cardiomyopathy (weakening of the heart muscle): 111 reports
- Cardio-respiratory arrest (sudden dysfunction of heart and lungs): 131 reports
- Cataract (clouding of the lens inside the eye): 165 reports
- Cellulitis (infection under the skin): 296 reports
- Chest pain: 1,006 reports
- Chills (felling of cold): 305 reports
- Chronic kidney disease: 209 reports
- Chronic obstructive pulmonary disease (a progressive disease that makes it hard to breathe): 244 reports
- Cognitive disorder (mental health disorders affects learning, memory, perception, and problem solving): 434 reports
- Completed suicide (act of taking one's own life): 179 reports
- Condition: 1,004 reports
- Confusion: 645 reports
- Confusional state: 1,247 reports
- Congenital anomaly (birth defect): 316 reports
- Consciousness - decreased: 575 reports
- Constipation: 703 reports
- Convulsion (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled shaking of the body): 1,962 reports
- Convulsions (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled of muscles contract and relax rapidly and repeatedly): 334 reports
- Coronary heart disease (narrowing or blockage of the coronary arteries): 118 reports
- Cough: 480 reports
- Crying: 295 reports
- Cuts and puncture wounds: 106 reports
- Death: 747 reports
- Deep venous thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis): 241 reports
- Deformity (disfigurement): 655 reports
- Dehydration (dryness resulting from the removal of water): 602 reports
- Delirium (wild excitement): 231 reports
- Delusion (a false belief or opinion): 330 reports
- Dementia (madness): 185 reports
- Depressed level of consciousness: 297 reports
- Depressed mood: 263 reports
- Depression: 1,999 reports
- Dermatitis (inflammation of the skin resulting from direct irritation by an external agent or an allergic reaction to it): 189 reports
- Developmental delay: 139 reports
- Diabetes: 1,596 reports
- Diabetes mellitus inadequate control: 395 reports
- Diabetic ketoacidosis (diabetic ketoacidosis (dka) is high concentrations of ketone bodies): 638 reports
- Diabetic neuropathy (neuropathic disorders that are associated with diabetes mellitus): 287 reports
- Diarrhea: 1,254 reports
- Difficulty in walking: 130 reports
- Diplopia (double vision): 170 reports
- Disability: 168 reports
- Disturbance in attention: 475 reports
- Dizziness: 1,729 reports
- Drooling (drop saliva uncontrollably from the mouth): 211 reports
- Drowsiness: 2,042 reports
- Drug abuse and dependence: 217 reports
- Drug administration error: 108 reports
- Drug dependence: 300 reports
- Drug effect decreased: 269 reports
- Drug exposure during pregnancy: 422 reports
- Drug hypersensitivity: 667 reports
- Drug ineffective: 2,547 reports
- Drug intolerance (drug sensitivity): 138 reports
- Drug level decreased: 275 reports
- Drug level increased: 278 reports
- Drug maladministration: 115 reports
- Drug toxicity: 267 reports
- Drug withdrawal syndrome (interfere with normal social, occupational, or other functioning. are not due to another medical condition, drug use, or discontinuation): 380 reports
- Dry mouth: 326 reports
- Dry skin: 115 reports
- Dyskinesia (abnormality or impairment of voluntary movement): 452 reports
- Dysstasia (difficulty in standing): 126 reports
- Ear pain: 109 reports
- Eating disorder: 153 reports
- Electrocardiogram qt prolonged: 200 reports
- Emotional disorder: 272 reports
- Emotional distress: 1,079 reports
- Encephalopathy (functioning of the brain is affected by some agent or condition): 297 reports
- Enlarged heart: 101 reports
- Epilepsy (common and diverse set of chronic neurological disorders characterized by seizures): 251 reports
- Erection problems: 286 reports
- Erythema multiforme (a type of hypersensitivity reaction): 287 reports
- Extrapyramidal disorder (involuntary muscle spasms in the face and neck): 312 reports
- Eye disorder: 112 reports
- Eye pain: 113 reports
- Face oedema (swelling of face): 112 reports
- Fainting (loss of consciousness and postural tone): 383 reports
- Fall: 1,788 reports
- Fatigue (feeling of tiredness): 2,577 reports
- Fear: 170 reports
- Feeling hot: 152 reports
- Fever: 1,242 reports
- Fibromyalgia (a long-term condition which causes pain all over the body): 144 reports
- Flatulence (flatus expelled through the anus): 132 reports
- Foetal exposure during pregnancy (exposing your unborn child to contraindicated in pregnancy leads birth defect): 730 reports
- Foot fracture: 119 reports
- Gait disturbance: 830 reports
- Gallbladder disorder: 126 reports
- Gallstones (stone formation by bile component): 169 reports
- Gastric disorder (disease of stomach): 135 reports
- Gastric ulcer (stomach ulcer): 143 reports
- Gastritis (inflammation of stomach): 149 reports
- Gastroesophageal reflux disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 414 reports
- Gastrointestinal disorder (functional problems of gastrointestinal tract): 215 reports
- Gastrointestinal haemorrhage (bleeding gastrointestinal tract): 162 reports
- General physical health deterioration (weak health status): 231 reports
- Glucose tolerance impaired (blood glucose is raised beyond normal levels, but not high enough to warrant a diabetes diagnosis): 105 reports
- Grand mal convulsion (a type of generalized seizure that affects the entire brain): 398 reports
- Gynecomastia (enlargement of the gland tissue of the male breast): 422 reports
- Haematemesis (vomiting of blood): 110 reports
- Haematochezia (passage of stools containing blood): 120 reports
- Haematocrit decreased: 128 reports
- Haemoglobin decreased: 280 reports
- Haemorrhage (bleeding): 181 reports
- Haemorrhoids (a swollen vein or group of veins in the region of the anus): 110 reports
- Hair loss: 1,179 reports
- Hallucination, auditory (perceiving sounds without auditory stimulus): 338 reports
- Hallucinations (sensations that appear real but are created by your mind): 608 reports
- Hallucination, visual (seeing things that aren't there): 175 reports
- Headache (pain in head): 1,967 reports
- Head injury: 734 reports
- Hearing loss: 103 reports
- Heart attack: 467 reports
- Heart palpitations (feelings or sensations that your heart is pounding or racing): 387 reports
- Heart rate increased: 313 reports
- Hepatic enzyme increased: 239 reports
- Hepatic failure (liver failure): 184 reports
- Hepatic steatosis (fatty liver disease): 170 reports
- Hepatitis (inflammation of the liver): 124 reports
- High blood cholesterol: 1,030 reports
- High blood pressure: 1,338 reports
- Hoarseness or changing voice: 112 reports
- Homicidal ideation (thoughts about human killing another human): 130 reports
- Hospitalisation: 355 reports
- Hostility: 133 reports
- Hot flush (sudden feelings of heat): 111 reports
- Hyperammonaemia: 237 reports
- Hyperglycemia (high blood sugar): 425 reports
- Hyperhidrosis (abnormally increased sweating): 397 reports
- Hyperkalemia (damage to or disease of the kidney): 141 reports
- Hyperlipidaemia (presence of excess lipids in the blood): 348 reports
- Hypernatraemia (an abnormally high plasma concentration of sodium ions): 107 reports
- Hyperprolactinaemia (abnormally high levels of prolactin in the blood): 105 reports
- Hypersensitivity: 403 reports
- Hypoaesthesia (reduced sense of touch or sensation): 523 reports
- Hypoglycemia (low blood sugar): 288 reports
- Hypokalemia (low potassium): 133 reports
- Hypomania (a mild form of mania, marked by elation and hyperactivity): 140 reports
- Hyponatremia (abnormally low level of sodium in the blood; associated with dehydration): 320 reports
- Hypotension (abnormally low blood pressure): 841 reports
- Hypothermia (body temperature drops below the required temperature for normal metabolism and body functions): 112 reports
- Hypothyroidism (abnormally low activity of the thyroid gland, resulting in retardation of growth and mental development): 222 reports
- Ill-defined disorder: 213 reports
- Impaired work ability: 301 reports
- Incontinence (lack of moderation or self-control): 109 reports
- Indigestion: 305 reports
- Infection: 268 reports
- Influenza like illness: 238 reports
- Injection site pain: 258 reports
- Injury: 884 reports
- Insomnia (sleeplessness): 1,668 reports
- Intentional overdose: 215 reports
- Intentional self-injury: 180 reports
- International normalised ratio increased: 115 reports
- Intervertebral disc protrusion (spinal disc protrusion): 150 reports
- Intestinal obstruction: 110 reports
- Irritability: 606 reports
- Irritable bowel syndrome: 112 reports
- Itching: 494 reports
- Joint injury: 105 reports
- Joint pain: 725 reports
- Joint stiffness: 108 reports
- Joint swelling: 214 reports
- Kidney stones: 128 reports
- Leukocytosis (increased white blood cells): 103 reports
- Leukopenia (less number of white blood cells in blood): 376 reports
- Limb injury: 114 reports
- Liver disorder (liver diseases): 149 reports
- Loss of consciousness: 798 reports
- Loss of employment: 373 reports
- Low tissue oxygen: 134 reports
- Lung disorder (lung disease): 138 reports
- Lymph follicular hypertrophy (an increase in the size of the lymph node follicles): 198 reports
- Major depression (a mood state that goes well beyond temporarily feeling sad or blue. it is a serious medical illness that affects one's thoughts, feelings): 137 reports
- Malaise (a feeling of general discomfort or uneasiness): 1,120 reports
- Mania (a state of abnormally elevated or irritable mood): 841 reports
- Maternal exposure during pregnancy (use of substance during pregnancy): 168 reports
- Memory loss: 1,260 reports
- Mental disorder (a psychological term for a mental or behavioural pattern or anomaly that causes distress or disability): 503 reports
- Mental impairment (a condition affecting the body, perhaps through sight or hearing loss, a mobility difficulty or a health condition): 293 reports
- Mental status changes (general changes in brain function, such as confusion, amnesia (memory loss), loss of alertness, loss of orientation): 317 reports
- Metabolic acidosis (body produces too much acid, or when the kidneys are not removing enough acid from the body): 139 reports
- Metabolic disorder (an abnormal function and pattern of body fat. insulin resistance refers to the diminished ability of cells to respond to the action of insulin in promoting the transport of the sugar glucose, from blood into muscles and other tissues): 122 reports
- Migraine (headache): 547 reports
- Mobility decreased (ability to move is reduced): 190 reports
- Mood swings (an extreme or rapid change in mood): 540 reports
- Movement disorder (neurological syndromes where they may be excess of movement or a paucity of movement that is not connected to weakness): 168 reports
- Movement - uncontrolled or slow: 163 reports
- Movement - uncoordinated: 179 reports
- Multiple congenital abnormalities (more than one birth defects): 124 reports
- Multiple injuries: 254 reports
- Multiple sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath): 171 reports
- Multiple sclerosis relapse (reoccurrence of a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath): 170 reports
- Muscle aches (muscle pain): 404 reports
- Muscle rigidity (muscle stiffness): 141 reports
- Muscle spasms (muscle contraction): 470 reports
- Muscle twitching: 164 reports
- Musculoskeletal pain (pain affects the bones, muscles, ligaments, tendons, and nerves): 165 reports
- Musculoskeletal stiffness (stiffness of the body's muscles, joints, tendons, ligaments and nerves): 208 reports
- Myelomeningocele (children) (a defect of the backbone and spinal cord, which don't close properly before birth): 439 reports
- Nasopharyngitis (inflammation of the nasopharynx): 269 reports
- Nausea (feeling of having an urge to vomit): 2,141 reports
- Nausea and vomiting: 1,442 reports
- Neck pain: 265 reports
- Nervousness: 418 reports
- Nervous system disorder (a general class of medical conditions affecting the nervous system): 190 reports
- Neural tube defect (birth defects of the brain, spine, or spinal cord): 335 reports
- Neuroleptic malignant syndrome (a life-threatening neurological disorder most often caused by an adverse reaction to neuroleptic or antipsychotic agents): 318 reports
- Neuropathy peripheral (surface nerve damage): 459 reports
- Neutrophil count decreased (less than normal number of neutrophil a type of blood cell): 200 reports
- Nightmares (unpleasant dreams): 284 reports
- Nosebleed (bleeding from nose): 150 reports
- Obsessive-compulsive disorder (an anxiety disorder characterized by intrusive thoughts that produce uneasiness, apprehension, fear, or worry;): 190 reports
- Oedema (fluid collection in tissue): 328 reports
- Oedema peripheral (superficial swelling): 673 reports
- Oropharyngeal pain: 174 reports
- Osteoarthritis (a joint disease caused by cartilage loss in a joint): 147 reports
- Osteopenia (a condition where bone mineral density is lower than normal): 103 reports
- Osteoporosis (bones weak and more likely to break): 220 reports
- Otitis (ear infection): 117 reports
- Overdose: 1,006 reports
- Oxygen saturation decreased: 184 reports
- Pain: 2,245 reports
- Pain in extremity: 714 reports
- Paleness (unusual lightness of skin colour): 131 reports
- Pancreatitis (inflammation of pancreas): 908 reports
- Pancreatitis acute (sudden inflammation of pancreas): 200 reports
- Pancytopenia (medical condition in which there is a reduction in the number of red and white blood cells, as well as platelets): 191 reports
- Panic disorder: 346 reports
- Paraesthesia (sensation of tingling, tickling, prickling, pricking, or burning of a person's skin with no apparent long-term physical effect): 510 reports
- Paranoia (psychotic disorder characterized by delusions of persecution with or without grandeur): 399 reports
- Parkinson's disease: 281 reports
- Peripheral swelling: 241 reports
- Petit mal epilepsy (absence seizure): 194 reports
- Photophobia (extreme sensitivity to light): 114 reports
- Physical disability: 594 reports
- Pleural effusion (water on the lungs): 216 reports
- Pneumonia: 936 reports
- Pneumonia aspiration (bronchopneumonia that develops due to the entrance of foreign materials into the bronchial tree): 190 reports
- Pollakiuria (abnormally frequent passage of relatively small quantities or urine): 176 reports
- Poor quality sleep: 133 reports
- Post-traumatic stress disorder: 109 reports
- Prescribed overdose: 217 reports
- Psychomotor hyperactivity (feelings of extreme restlessness): 239 reports
- Psychotic disorder: 751 reports
- Pulmonary embolism (blockage of the main artery of the lung): 301 reports
- Pulmonary oedema (fluid accumulation in the lungs): 167 reports
- Quality of life decreased: 115 reports
- Rashes (redness): 1,307 reports
- Rectal haemorrhage (bleeding from anus): 158 reports
- Red blood cell count decreased: 125 reports
- Renal disorder (kidney disease): 146 reports
- Renal failure acute (rapid kidney dysfunction): 307 reports
- Renal impairment (severely reduced kidney function): 109 reports
- Respiratory acidosis (respiratory failure or ventilatory failure, causes the ph of blood and other bodily fluids to decrease): 191 reports
- Respiratory distress (difficulty in breathing): 151 reports
- Restless leg syndrome (a powerful urge to move your legs): 154 reports
- Retching (strong involuntary effort to vomit): 122 reports
- Rhabdomyolysis (a condition in which damaged skeletal muscle tissue breaks down): 292 reports
- Rib fracture: 108 reports
- Road traffic accident: 352 reports
- Salivary hypersecretion (excess saliva secretion): 121 reports
- Scar: 109 reports
- Schizoaffective disorder (a mental disorder characterized by disordered thought): 178 reports
- Schizophrenia (a mental disorder characterized by a breakdown of thought processes): 202 reports
- Sedation: 824 reports
- Seizures (abnormal excessive or synchronous neuronal activity in the brain): 1,688 reports
- Sepsis (a severe blood infection that can lead to organ failure and death): 343 reports
- Sinusitis (inflammation of sinus): 267 reports
- Skin blushing/flushing (a sudden reddening of the face, neck): 142 reports
- Skin discoloration: 187 reports
- Skin exfoliation (removal of the oldest dead skin cells): 112 reports
- Sleep apnea syndrome: 320 reports
- Sleep disorder: 288 reports
- Social problem: 309 reports
- Speech disorder: 567 reports
- Speech impairment (adult) (inability to speak (adult)): 659 reports
- Staphylococcal infection (an infection with staphylococcus bacteria): 110 reports
- Status epilepticus (a life-threatening condition in which the brain is in a state of persistent seizure): 164 reports
- Stomatitis (inflammation of mucous membrane of mouth): 113 reports
- Stress and anxiety: 2,425 reports
- Stroke (sudden death of a portion of the brain cells due to a lack of oxygen): 481 reports
- Suicidal ideation: 1,173 reports
- Suicide attempt: 822 reports
- Surgery: 113 reports
- Swallowing difficulty: 515 reports
- Swelling: 195 reports
- Swelling face: 134 reports
- Tardive dyskinesia (a disorder that involves involuntary movements): 408 reports
- Taste - impaired: 118 reports
- The flu (the flu is caused by an influenza virus): 207 reports
- Therapeutic response decreased (less preventive response): 116 reports
- Therapeutic response unexpected: 141 reports
- Thirst: 145 reports
- Thrombocytopenia (decrease of platelets in blood): 1,127 reports
- Thrombosis (formation of a blood clot inside a blood vessel): 162 reports
- Tinnitus (a ringing in the ears): 222 reports
- Tooth abscess (pus formation in tooth): 101 reports
- Tooth disorder (tooth disease): 120 reports
- Transient ischaemic attack (a transient episode of neurologic dysfunction caused by ischemia (loss of blood flow)): 182 reports
- Tremor (trembling or shaking movements in one or more parts of your body): 2,089 reports
- Type 1 diabetes: 296 reports
- Type 2 diabetes: 1,290 reports
- Unresponsive to stimuli: 130 reports
- Upper respiratory tract infection: 196 reports
- Urinary incontinence (inability to control the flow of urine and involuntary urination): 404 reports
- Urinary retention (the inability to completely or partially empty the bladder): 156 reports
- Urinary tract infection: 750 reports
- Urination - excessive volume: 120 reports
- Urination - painful: 212 reports
- Urticaria (rash of round, red welts on the skin that itch intensely): 258 reports
- Viral infection: 111 reports
- Vision blurred: 642 reports
- Visual acuity reduced (reduced clearness of vision): 129 reports
- Visual impairment: 274 reports
- Weakness: 1,732 reports
- Weight decreased: 1,196 reports
- Weight increased: 2,701 reports
- Weight loss: 612 reports
- White blood cell count decreased: 482 reports
- White blood cell count increased: 254 reports
- Withdrawal syndrome (a discontinuation syndrome is a set of symptoms occurred due to discontinuation of substance): 171 reports
How the study uses the data?
The study is based on methylphenidate hydrochloride and divalproex sodium (the active ingredients of Concerta and Depakote, respectively). Other drugs that have the same active ingredients (e.g. generic drugs or brand names) are also considered. Dosage of drugs is not considered in the study.
Who is eHealthMe?
With medical big data and proven AI algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 600+ medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).
WARNING, DISCLAIMER, USE FOR PUBLICATION
WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.
DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.
If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.
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