Gabapentin vs. Amitriptyline hydrochloride


We compare the side effects and drug effectiveness of Gabapentin and Amitriptyline hydrochloride. The study is created by eHealthMe based on reports of 303,111 people who take Gabapentin and Amitriptyline hydrochloride, and is updated regularly.

What's eHealthMe?

eHealthMe is a health data analysis company based in Mountain View, California. eHealthMe monitors and analyzes the outcomes of drugs and supplements that are currently on the market. The results are readily available to health care professionals and consumers.

eHealthMe has released original studies on market drugs and worked with leading universities and institutions such as IBM, London Health Science Centre, Mayo Clinic, Northwestern University and VA. eHealthMe studies have now been referenced in over 500 peer-reviewed medical publications.

How we gather our data?

Healthcare data is obtained from a number of sources including the Food and Drug Administration (FDA). This information is aggregated and used to produce personalized reports that patients can reference.

The information that eHealthMe collects includes:

  • Side effects (including severity and how people recover from them)
  • Associated conditions or symptoms
  • Drug effectiveness
  • Demographic data regarding drug use

How the study uses the data?

The study is based on gabapentin and amitriptyline hydrochloride (the active ingredients of Gabapentin and Amitriptyline hydrochloride, respectively). Other drugs that have the same active ingredients (e.g. generic drugs or brand names) are also considered.

What is Gabapentin?

Gabapentin has active ingredients of gabapentin. It is often used in neuralgia. (latest outcomes from Gabapentin 147,960 users)

What is Amitriptyline hydrochloride?

Amitriptyline hydrochloride has active ingredients of amitriptyline hydrochloride. It is often used in migraine. (latest outcomes from Amitriptyline hydrochloride 9,789 users)

How to use the study?

Patients can bring a copy of the report to their healthcare provider to ensure that all drug risks and benefits are fully discussed and understood. It is recommended that patients use the information presented as a part of a broader decision-making process.

On Mar, 23, 2019

303,111 people who take Gabapentin and Amitriptyline hydrochloride are studied.

Number of reports submitted per year:

Gabapentin vs Amitriptyline hydrochloride drug comparison reports.

Drugs in this study:

  • Amitriptyline Hydrochloride (amitriptyline hydrochloride)
  • Gabapentin (gabapentin)

Most common side effects:

  1. Nausea (feeling of having an urge to vomit)
  2. Headache (pain in head)
  3. Fatigue (feeling of tiredness)
  4. Drug Ineffective
  5. Dyspnoea (difficult or laboured respiration)
  6. Anxiety
  7. Dizziness
  8. Fall
  9. Diarrhoea
  10. Vomiting
Amitriptyline Hydrochloride:
  1. Drug Ineffective
  2. Nausea (feeling of having an urge to vomit)
  3. Fatigue (feeling of tiredness)
  4. Headache (pain in head)
  5. Dizziness
  6. Fall
  7. Diarrhoea
  8. Dyspnoea (difficult or laboured respiration)
  9. Asthenia (weakness)
  10. Pain In Extremity

Most common side effects experienced by people in long term use:

  1. Anxiety
  2. Fatigue (feeling of tiredness)
  3. Nausea (feeling of having an urge to vomit)
  4. Dizziness
  5. Headache (pain in head)
  6. Insomnia (sleeplessness)
  7. Pyrexia (fever)
  8. Suicidal Ideation
  9. Dyspnoea (difficult or laboured respiration)
  10. Fall
Amitriptyline Hydrochloride:
  1. Drug Ineffective
  2. Anxiety
  3. Suicidal Ideation
  4. Fatigue (feeling of tiredness)
  5. Dizziness
  6. Nausea (feeling of having an urge to vomit)
  7. Somnolence (a state of near-sleep, a strong desire for sleep)
  8. Headache (pain in head)
  9. Condition
  10. Fall

Drug effectiveness:

  • not at all: 6.16 %
  • somewhat: 27.38 %
  • moderate: 35.27 %
  • high: 22.97 %
  • very high: 8.21 %
Amitriptyline Hydrochloride:
  • not at all: 6.67 %
  • somewhat: 30.9 %
  • moderate: 35.88 %
  • high: 19.85 %
  • very high: 6.69 %

Do you take Gabapentin or Amitriptyline hydrochloride?

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WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only, and has not been supported by scientific studies or clinical trials unless otherwise stated. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

You may report adverse side effects to the FDA at or 1-800-FDA-1088 (1-800-332-1088).

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.