Invokana vs. Lisinopril: side effect and effectiveness comparison - a phase IV clinical study
Summary:
We compare the side effects and drug effectiveness of Invokana and Lisinopril. The phase IV clinical study is created by eHealthMe based on reports (from sources including the FDA) of 390,968 people who take Invokana and Lisinopril, and is updated regularly. You can use the study as a second opinion to make health care decisions.
Phase IV trials are used to detect adverse drug outcomes and monitor drug effectiveness in the real world. With medical big data and AI algorithms, eHealthMe is running millions of phase IV trials and makes the results available to the public. Our original studies have been referenced on 600+ medical publications including The Lancet, Mayo Clinic Proceedings, and Nature.
390,968 people who take Invokana and Lisinopril are studied.
What is Invokana?
Invokana has active ingredients of canagliflozin. It is often used in diabetes. eHealthMe is studying from 28,853 Invokana users for its effectiveness, alternative drugs and more.
What is Lisinopril?
Lisinopril has active ingredients of lisinopril. It is often used in high blood pressure. eHealthMe is studying from 325,399 Lisinopril users for its effectiveness, alternative drugs and more.
Number of reports submitted per year:

Drugs being compared in this study:
- Lisinopril (lisinopril)
- Invokana (canagliflozin)
Most common side effects of the drugs, overall:
Most common side effects of the drugs, in long term (1+ years) use:
Drug effectiveness:
Invokana:
- not at all: 2.31 %
- somewhat: 16.67 %
- moderate: 44.44 %
- high: 26.85 %
- very high: 9.72 %
Lisinopril:
- not at all: 1.54 %
- somewhat: 13.33 %
- moderate: 33.86 %
- high: 37.54 %
- very high: 13.73 %
Want to compare Invokana with Lisinopril?
Personalize this study to your gender and age (0-99+).How to use the study?
You can discuss the study with your doctor, to ensure that all drug risks and benefits are fully discussed and understood.
Related publications that referenced our studies
- Dobrosavljevi? Vukojevi? D, Stojkovi? Filipovi? J, Sjerobabin M, Vukovi? J, Vesi? S, "Lisinopril-induced pemphigus foliaceus in a patient with diabetes mellitus and Kaposi-Juliusberg varicelliform eruption", Serbian Journal of Dermatology and Venerology, 2012 Dec .
Related studies
Alternative drugs to, pros and cons of:
- Invokana (28,609 reports)
- Lisinopril (311,466 reports)
Common Invokana side effects:
- Diabetic ketoacidosis (diabetic ketoacidosis (dka) is high concentrations of ketone bodies): 4,429 reports
- Osteomyelitis (infection of bone): 2,342 reports
- Weight decreased: 1,336 reports
- Gangrene (body tissue dies): 1,163 reports
- Cellulitis (infection under the skin): 1,103 reports
- Urinary tract infection: 1,086 reports
- Drug ineffective: 917 reports
Browse all side effects of Invokana:
a b c d e f g h i j k l m n o p q r s t u v w x y zCommon Lisinopril side effects:
- Fatigue (feeling of tiredness): 20,962 reports
- Diarrhea: 17,320 reports
- Drug ineffective: 16,717 reports
- Pain: 15,476 reports
- Breathing difficulty: 15,475 reports
- High blood pressure: 14,865 reports
- Dizziness: 14,554 reports
Browse all side effects of Lisinopril:
a b c d e f g h i j k l m n o p q r s t u v w x y zHow the study uses the data?
The study is based on canagliflozin and lisinopril (the active ingredients of Invokana and Lisinopril, respectively). Other drugs that have the same active ingredients (e.g. generic drugs or brand names) are also considered. Dosage of drugs is not considered in the study.
Who is eHealthMe?
With medical big data and proven AI algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 600+ medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).
WARNING, DISCLAIMER, USE FOR PUBLICATION
WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.
DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.
If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.
Recent studies on eHealthMe:
- How effective is Folic Acid for Infertility? - 15 seconds ago
- Cyclocort and Chest Pain - 17 seconds ago
- Granisetron Hydrochloride and Osteoarthritis Aggravated - 23 seconds ago
- Armodafinil and Low Density Lipoprotein Increased - 34 seconds ago
- Transderm-Nitro and Hyponatraemia Aggravated - 38 seconds ago
- Flecainide Acetate and Heavy Or Prolong Menstrual Bleeding - 48 seconds ago
- Prednisolone and Meibomianitis - 50 seconds ago
- Tri-Luma and Hypertension Aggravated - 50 seconds ago
- Catapres-Tts-1 and Dyskinesia - 52 seconds ago
- Abilify and Lymphocytic Infiltration - 56 seconds ago