Lamictal vs. Melatonin


We compare the side effects and drug effectiveness of Lamictal and Melatonin. The study is created by eHealthMe based on reports of 119,885 people who take Lamictal and Melatonin, and is updated regularly.

What's eHealthMe?

eHealthMe is a health data analysis company based in Mountain View, California. eHealthMe monitors and analyzes the outcomes of drugs and supplements that are currently on the market. The results are readily available to health care professionals and consumers.

eHealthMe has released original studies on market drugs and worked with leading universities and institutions such as IBM, London Health Science Centre, Mayo Clinic, Northwestern University and VA. eHealthMe studies have now been referenced in over 500 peer-reviewed medical publications.

How we gather our data?

Healthcare data is obtained from a number of sources including the Food and Drug Administration (FDA). This information is aggregated and used to produce personalized reports that patients can reference.

The information that eHealthMe collects includes:

  • Side effects (including severity and how people recover from them)
  • Associated conditions or symptoms
  • Drug effectiveness
  • Demographic data regarding drug use

How the study uses the data?

The study is based on lamotrigine and melatonin (the active ingredients of Lamictal and Melatonin, respectively). Other drugs that have the same active ingredients (e.g. generic drugs or brand names) are also considered.

What is Lamictal?

Lamictal has active ingredients of lamotrigine. It is often used in bipolar disorder. (latest outcomes from Lamictal 64,115 users)

What is Melatonin?

Melatonin has active ingredients of melatonin. It is often used in insomnia. (latest outcomes from Melatonin 18,393 users)

How to use the study?

Patients can bring a copy of the report to their healthcare provider to ensure that all drug risks and benefits are fully discussed and understood. It is recommended that patients use the information presented as a part of a broader decision-making process.

On Mar, 09, 2019

119,885 people who take Lamictal and Melatonin are studied.

Number of reports submitted per year:

Lamictal vs Melatonin drug comparison reports.

Drugs in this study:

  • Melatonin (melatonin)
  • Lamictal (lamotrigine)

Most common side effects:

  1. Fatigue (feeling of tiredness)
  2. Nausea (feeling of having an urge to vomit)
  3. Drug Ineffective
  4. Headache (pain in head)
  5. Diarrhoea
  6. Pain
  7. Dizziness
  8. Dyspnoea (difficult or laboured respiration)
  9. Fall
  10. Anxiety
  1. Rash
  2. Drug Ineffective
  3. Convulsion (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled shaking of the body)
  4. Pyrexia (fever)
  5. Nausea (feeling of having an urge to vomit)
  6. Headache (pain in head)
  7. Dizziness
  8. Fatigue (feeling of tiredness)
  9. Depression
  10. Vomiting

Most common side effects experienced by people in long term use:

  1. Pre-Existing Condition Improved
  2. Therapeutic Response Unexpected
  3. Depression
  4. Weight Decreased
  5. Nausea (feeling of having an urge to vomit)
  6. Headache (pain in head)
  7. Anxiety
  8. Drug Ineffective
  9. Fall
  10. Muscle Spasms (muscle contraction)
  1. Rash
  2. Depression
  3. Drug Ineffective
  4. Anxiety
  5. Dizziness
  6. Fatigue (feeling of tiredness)
  7. Convulsion (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled shaking of the body)
  8. Nausea (feeling of having an urge to vomit)
  9. Headache (pain in head)
  10. Tremor (trembling or shaking movements in one or more parts of your body)

Drug effectiveness:

  • not at all: 3.52 %
  • somewhat: 24.67 %
  • moderate: 37.08 %
  • high: 25.2 %
  • very high: 9.53 %
  • not at all: 3.47 %
  • somewhat: 18.2 %
  • moderate: 30.76 %
  • high: 31.12 %
  • very high: 16.46 %

Do you take Lamictal or Melatonin?

You are not alone:

Related publications that referenced our studies

Related studies:

Compare Lamictal with similar drugs
Compare Melatonin with similar drugs

Recent updates

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WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only, and has not been supported by scientific studies or clinical trials unless otherwise stated. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

You may report adverse side effects to the FDA at or 1-800-FDA-1088 (1-800-332-1088).

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.