Lortab vs. Benadryl


We compare the side effects and drug effectiveness of Lortab and Benadryl. The study is created by eHealthMe based on reports of 257,380 people who take Lortab and Benadryl, and is updated regularly.

What's eHealthMe?

eHealthMe is a health data analysis company based in Mountain View, California. eHealthMe monitors and analyzes the outcomes of drugs and supplements that are currently on the market. The results are readily available to health care professionals and consumers.

eHealthMe has released original studies on market drugs and worked with leading universities and institutions such as IBM, London Health Science Centre, Mayo Clinic, Northwestern University and VA. eHealthMe studies have now been referenced in over 500 peer-reviewed medical publications.

How we gather our data?

Healthcare data is obtained from a number of sources including the Food and Drug Administration (FDA). This information is aggregated and used to produce personalized reports that patients can reference.

The information that eHealthMe collects includes:

  • Side effects (including severity and how people recover from them)
  • Associated conditions or symptoms
  • Drug effectiveness
  • Demographic data regarding drug use

How the study uses the data?

The study is based on acetaminophen; hydrocodone bitartrate and diphenhydramine hydrochloride (the active ingredients of Lortab and Benadryl, respectively), and Lortab and Benadryl (the brand names). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered.

What is Lortab?

Lortab has active ingredients of acetaminophen; hydrocodone bitartrate. It is often used in pain. (latest outcomes from Lortab 24,483 users)

What is Benadryl?

Benadryl has active ingredients of diphenhydramine hydrochloride. It is often used in allergies. (latest outcomes from Benadryl 57,530 users)

How to use the study?

Patients can bring a copy of the report to their healthcare provider to ensure that all drug risks and benefits are fully discussed and understood. It is recommended that patients use the information presented as a part of a broader decision-making process.

On Feb, 20, 2019

257,380 people who take Lortab and Benadryl are studied.

Number of reports submitted per year:

Lortab vs Benadryl drug comparison reports.

Drugs in this study:

  • Benadryl (diphenhydramine hydrochloride)
  • Lortab (acetaminophen; hydrocodone bitartrate)

eHealthMe real world results:

Most common side effects:

  1. Nausea (feeling of having an urge to vomit)
  2. Dyspnoea (difficult or laboured respiration)
  3. Fatigue (feeling of tiredness)
  4. Headache (pain in head)
  5. Vomiting
  6. Diarrhoea
  7. Pyrexia (fever)
  8. Rash
  9. Drug Ineffective
  10. Infusion Related Reaction
  1. Death
  2. Nausea (feeling of having an urge to vomit)
  3. Fatigue (feeling of tiredness)
  4. Dyspnoea (difficult or laboured respiration)
  5. Drug Ineffective
  6. Anxiety
  7. Headache (pain in head)
  8. Vomiting
  9. Overdose
  10. Diarrhoea

Most common side effects experienced by people in long term use:

  1. Drug Ineffective
  2. Weight Decreased
  3. Infusion Related Reaction
  4. Arthralgia (joint pain)
  5. Headache (pain in head)
  6. Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints)
  7. Fatigue (feeling of tiredness)
  8. Nausea (feeling of having an urge to vomit)
  9. Blood Pressure Increased
  10. Diarrhoea
  1. Depression
  2. Anxiety
  3. Nausea (feeling of having an urge to vomit)
  4. Drug Ineffective
  5. Headache (pain in head)
  6. Injury
  7. Hypertension (high blood pressure)
  8. Fall
  9. Emotional Distress
  10. Myocardial Infarction (destruction of heart tissue resulting from obstruction of the blood supply to the heart muscle)

Drug effectiveness:

  • not at all: 3.26 %
  • somewhat: 24.91 %
  • moderate: 35.78 %
  • high: 26.74 %
  • very high: 9.32 %
  • not at all: 1.5 %
  • somewhat: 21.68 %
  • moderate: 41.8 %
  • high: 26.98 %
  • very high: 8.04 %

Do you take Lortab or Benadryl?

You are not alone:

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WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only, and has not been supported by scientific studies or clinical trials unless otherwise stated. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

You may report adverse side effects to the FDA at http://www.fda.gov/medwatch/ or 1-800-FDA-1088 (1-800-332-1088).

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.

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