Melatonin vs. Zanaflex


We compare the side effects and drug effectiveness of Melatonin and Zanaflex. The study is created by eHealthMe based on reports of 49,464 people who take Melatonin and Zanaflex, and is updated regularly.

What's eHealthMe?

eHealthMe is a health data analysis company based in Mountain View, California. eHealthMe monitors and analyzes the outcomes of drugs and supplements that are currently on the market. The results are readily available to health care professionals and consumers.

eHealthMe has released original studies on market drugs and worked with leading universities and institutions such as IBM, London Health Science Centre, Mayo Clinic, Northwestern University and VA. eHealthMe studies have now been referenced in over 500 peer-reviewed medical publications.

How we gather our data?

Healthcare data is obtained from a number of sources including the Food and Drug Administration (FDA). This information is aggregated and used to produce personalized reports that patients can reference.

The information that eHealthMe collects includes:

  • Side effects (including severity and how people recover from them)
  • Associated conditions or symptoms
  • Drug effectiveness
  • Demographic data regarding drug use

How the study uses the data?

The study is based on melatonin and tizanidine hydrochloride (the active ingredients of Melatonin and Zanaflex, respectively). Other drugs that have the same active ingredients (e.g. generic drugs or brand names) are also considered.

What is Melatonin?

Melatonin has active ingredients of melatonin. It is often used in insomnia. (latest outcomes from Melatonin 18,393 users)

What is Zanaflex?

Zanaflex has active ingredients of tizanidine hydrochloride. It is often used in muscle spasms. (latest outcomes from Zanaflex 13,009 users)

How to use the study?

Patients can bring a copy of the report to their healthcare provider to ensure that all drug risks and benefits are fully discussed and understood. It is recommended that patients use the information presented as a part of a broader decision-making process.

On Feb, 28, 2019

49,464 people who take Melatonin and Zanaflex are studied.

Number of reports submitted per year:

Melatonin vs Zanaflex drug comparison reports.

Drugs in this study:

  • Melatonin (melatonin)
  • Zanaflex (tizanidine hydrochloride)

Most common side effects:

  1. Pain
  2. Nausea (feeling of having an urge to vomit)
  3. Fatigue (feeling of tiredness)
  4. Drug Ineffective
  5. Headache (pain in head)
  6. Fall
  7. Dizziness
  8. Depression
  9. Asthenia (weakness)
  10. Dyspnoea (difficult or laboured respiration)
  1. Fatigue (feeling of tiredness)
  2. Nausea (feeling of having an urge to vomit)
  3. Drug Ineffective
  4. Headache (pain in head)
  5. Diarrhoea
  6. Pain
  7. Dizziness
  8. Dyspnoea (difficult or laboured respiration)
  9. Fall
  10. Anxiety

Most common side effects experienced by people in long term use:

  1. Fall
  2. Depression
  3. Drug Ineffective
  4. Pain
  5. Dizziness
  6. Chronic Kidney Disease
  7. Nausea (feeling of having an urge to vomit)
  8. Anxiety
  9. Therapeutic Response Unexpected
  10. Weight Decreased
  1. Pre-Existing Condition Improved
  2. Depression
  3. Therapeutic Response Unexpected
  4. Headache (pain in head)
  5. Weight Decreased
  6. Nausea (feeling of having an urge to vomit)
  7. Anxiety
  8. Drug Ineffective
  9. Fall
  10. Migraine (headache)

Drug effectiveness:

  • not at all: 3.67 %
  • somewhat: 31.75 %
  • moderate: 36.81 %
  • high: 20.44 %
  • very high: 7.34 %
  • not at all: 3.55 %
  • somewhat: 24.63 %
  • moderate: 36.76 %
  • high: 25.49 %
  • very high: 9.56 %

Do you take Melatonin or Zanaflex?

You are not alone:

Related studies:

Compare Melatonin with similar drugs
Compare Zanaflex with similar drugs

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WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only, and has not been supported by scientific studies or clinical trials unless otherwise stated. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

You may report adverse side effects to the FDA at or 1-800-FDA-1088 (1-800-332-1088).

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.