Metformin hydrochloride vs. Duetact: side effect and effectiveness comparison - a phase IV clinical study
Summary:
We compare the side effects and drug effectiveness of Metformin hydrochloride and Duetact. The phase IV clinical study is created by eHealthMe based on reports (from sources including the FDA) of 462,447 people who take Metformin hydrochloride and Duetact, and is updated regularly. You can use the study as a second opinion to make health care decisions.
Phase IV trials are used to detect adverse drug outcomes and monitor drug effectiveness in the real world. With medical big data and AI algorithms, eHealthMe is running millions of phase IV trials and makes the results available to the public. Our original studies have been referenced on 600+ medical publications including The Lancet, Mayo Clinic Proceedings, and Nature.
462,447 people who take Metformin hydrochloride and Duetact are studied.
What is Metformin hydrochloride?
Metformin hydrochloride has active ingredients of metformin hydrochloride. It is often used in diabetes. eHealthMe is studying from 42,965 Metformin hydrochloride users for its effectiveness, alternative drugs and more.
What is Duetact?
Duetact has active ingredients of glimepiride; pioglitazone hydrochloride. It is often used in diabetes. eHealthMe is studying from 107 Duetact users for its effectiveness, alternative drugs and more.
Number of reports submitted per year:

Drugs being compared in this study:
- Metformin Hydrochloride (metformin hydrochloride)
- Duetact (glimepiride; pioglitazone hydrochloride)
Most common side effects of the drugs, overall:
Most common side effects of the drugs, in long term (1+ years) use:
Drug effectiveness:
Metformin Hydrochloride:
- not at all: 2.58 %
- somewhat: 19.64 %
- moderate: 38.29 %
- high: 30.11 %
- very high: 9.39 %
Duetact:
- not at all: 0 %
- somewhat: 25 %
- moderate: 0 %
- high: 0 %
- very high: 75 %
Want to compare Metformin hydrochloride with Duetact?
Personalize this study to your gender and age (0-99+).How to use the study?
You can discuss the study with your doctor, to ensure that all drug risks and benefits are fully discussed and understood.
Related publications that referenced our studies
- T.Audi Yanto, I.Huang, F.Nathania Kosasih, NP Hardjo Lugito, "Nightmare and Abnormal Dreams: Rare Side Effects of Metformin?", Case Reports in Endocrinology, 2018 Jan .
- Al-Hamdy RA, "Assessment of electrolytes and HbA1c in type 2 diabetic patients using metformin and evaluation of guidelines obedience regarding renal impairment", J.Thi-Qar Sci., 2015 Jan .
- Wiwanitkit S, Wiwanitkit V, "Metformin and sleep disorders", Indian journal of endocrinology and metabolism, 2012 Jan .
Related studies
Alternative drugs to, pros and cons of:
- Metformin hydrochloride (39,149 reports)
- Duetact (103 reports)
Common Metformin hydrochloride side effects:
- Lactic acidosis (low ph in body tissues): 3,307 reports
- Diarrhea: 2,870 reports
- Fatigue (feeling of tiredness): 2,017 reports
- Drug ineffective: 1,860 reports
- Indigestion: 1,775 reports
- Weakness: 1,673 reports
- Breathing difficulty: 1,564 reports
- High blood pressure: 1,556 reports
Browse all side effects of Metformin hydrochloride:
a b c d e f g h i j k l m n o p q r s t u v w x y zHow the study uses the data?
The study is based on metformin hydrochloride and glimepiride; pioglitazone hydrochloride (the active ingredients of Metformin hydrochloride and Duetact, respectively). Other drugs that have the same active ingredients (e.g. generic drugs or brand names) are also considered. Dosage of drugs is not considered in the study.
Who is eHealthMe?
With medical big data and proven AI algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 600+ medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).
WARNING, DISCLAIMER, USE FOR PUBLICATION
WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.
DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.
If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.
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