Norethindrone and ethinyl estradiol vs. Medroxyprogesterone acetate: side effect and effectiveness comparison - a phase IV clinical study
Summary:
We compare the side effects and drug effectiveness of Norethindrone and ethinyl estradiol and Medroxyprogesterone acetate. The phase IV clinical study is created by eHealthMe based on reports (from sources including the FDA) of 71,536 people who take Norethindrone and ethinyl estradiol and Medroxyprogesterone acetate, and is updated regularly. You can use the study as a second opinion to make health care decisions.
Phase IV trials are used to detect adverse drug outcomes and monitor drug effectiveness in the real world. With medical big data and AI algorithms, eHealthMe is running millions of phase IV trials and makes the results available to the public. Our original studies have been referenced on 600+ medical publications including The Lancet, Mayo Clinic Proceedings, and Nature.
71,536 people who take Norethindrone and ethinyl estradiol and Medroxyprogesterone acetate are studied.
What is Norethindrone and ethinyl estradiol?
Norethindrone and ethinyl estradiol has active ingredients of ethinyl estradiol; norethindrone. It is often used in birth control. eHealthMe is studying from 238 Norethindrone and ethinyl estradiol users for its effectiveness, alternative drugs and more.
What is Medroxyprogesterone acetate?
Medroxyprogesterone acetate has active ingredients of medroxyprogesterone acetate. It is often used in birth control. eHealthMe is studying from 11,960 Medroxyprogesterone acetate users for its effectiveness, alternative drugs and more.
Number of reports submitted per year:

Drugs being compared in this study:
- Medroxyprogesterone Acetate (medroxyprogesterone acetate)
- Norethindrone And Ethinyl Estradiol (ethinyl estradiol; norethindrone)
Most common side effects of the drugs, overall:
Most common side effects of the drugs, in long term (1+ years) use:
Drug effectiveness:
Norethindrone And Ethinyl Estradiol:
- not at all: 0.47000000000000003 %
- somewhat: 4.25 %
- moderate: 15.09 %
- high: 36.79 %
- very high: 43.4 %
Medroxyprogesterone Acetate:
- not at all: 4.0 %
- somewhat: 6.71 %
- moderate: 12.21 %
- high: 32.53 %
- very high: 44.54 %
Want to compare Norethindrone and ethinyl estradiol with Medroxyprogesterone acetate?
Personalize this study to your gender and age (0-99+).How to use the study?
You can discuss the study with your doctor, to ensure that all drug risks and benefits are fully discussed and understood.
Related publications that referenced our studies
- Bahall M, Reyes AJ, Ramcharan K, Hosein N, Seegobin K, Bahall K, Sharma H, Dhansingh S, Mahabir A, "Neuro-ophthalmological manifestations after intramuscular medroxyprogesterone: a forme fruste of idiopathic intracranial hypertension?", Neurology international, 2016 Sep .
Related studies
Alternative drugs to, pros and cons of:
- Norethindrone and ethinyl estradiol (207 reports)
- Medroxyprogesterone acetate (11,778 reports)
Common Medroxyprogesterone acetate side effects:
- Breast cancer: 2,765 reports
- Drug ineffective: 371 reports
- Pain: 262 reports
- Ovarian cancer (cancer of ovary): 247 reports
Browse all side effects of Medroxyprogesterone acetate:
a b c d e f g h i j k l m n o p q r s t u v w x y zHow the study uses the data?
The study is based on ethinyl estradiol; norethindrone and medroxyprogesterone acetate (the active ingredients of Norethindrone and ethinyl estradiol and Medroxyprogesterone acetate, respectively). Other drugs that have the same active ingredients (e.g. generic drugs or brand names) are also considered. Dosage of drugs is not considered in the study.
Who is eHealthMe?
With medical big data and proven AI algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 600+ medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).
WARNING, DISCLAIMER, USE FOR PUBLICATION
WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.
DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.
If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.
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