Nucynta er vs. Clonidine hydrochloride: side effect and effectiveness comparison - a phase IV clinical study
Summary:
We compare the side effects and drug effectiveness of Nucynta er and Clonidine hydrochloride. The phase IV clinical study is created by eHealthMe based on reports (from sources including the FDA) of 44,344 people who take Nucynta er and Clonidine hydrochloride, and is updated regularly. You can use the study as a second opinion to make health care decisions.
With medical big data and AI algorithms, eHealthMe enables everyone to run phase IV clinical trial to detect adverse drug outcomes and monitor effectiveness. Our original studies have been referenced on 600+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Most recently, phase IV clinial trails for COVID 19 vaccines have been added, check here.
44,344 people who take Nucynta er and Clonidine hydrochloride are studied.
What is Nucynta er?
Nucynta er has active ingredients of tapentadol hydrochloride. It is often used in pain. eHealthMe is studying from 2,215 Nucynta er users for its effectiveness, alternative drugs and more.
What is Clonidine hydrochloride?
Clonidine hydrochloride has active ingredients of clonidine hydrochloride. It is often used in high blood pressure. eHealthMe is studying from 3,158 Clonidine hydrochloride users for its effectiveness, alternative drugs and more.
Number of reports submitted per year:

Drugs being compared in this study:
- Clonidine Hydrochloride (clonidine hydrochloride)
- Nucynta Er (tapentadol hydrochloride)
Most common side effects of the drugs, overall:
Most common side effects of the drugs, in long term (1+ years) use:
Drug effectiveness:
Nucynta Er:
- not at all: 6.95 %
- somewhat: 26.82 %
- moderate: 35.76 %
- high: 23.84 %
- very high: 6.62 %
Clonidine Hydrochloride:
- not at all: 4.51 %
- somewhat: 25.06 %
- moderate: 36.22 %
- high: 23.68 %
- very high: 10.53 %
Want to compare Nucynta er with Clonidine hydrochloride?
Personalize this study to your gender and age (0-99+).How to use the study?
You can discuss the study with your doctor, to ensure that all drug risks and benefits are fully discussed and understood.
Related studies
Alternative drugs to, pros and cons of:
- Nucynta er (2,127 reports)
- Clonidine hydrochloride (2,155 reports)
Common Nucynta er side effects:
- Drug ineffective: 315 reports
- Pain: 150 reports
Common Clonidine hydrochloride side effects:
- Acute kidney failure: 157 reports
- Breathing difficulty: 118 reports
- Chronic kidney disease: 150 reports
- Drug ineffective: 192 reports
- Fatigue (feeling of tiredness): 118 reports
- Headache (pain in head): 120 reports
- High blood pressure: 249 reports
- Hypotension (abnormally low blood pressure): 140 reports
- Nausea (feeling of having an urge to vomit): 133 reports
- Weakness: 112 reports
How the study uses the data?
The study is based on tapentadol hydrochloride and clonidine hydrochloride (the active ingredients of Nucynta er and Clonidine hydrochloride, respectively). Other drugs that have the same active ingredients (e.g. generic drugs or brand names) are also considered. Dosage of drugs is not considered in the study.
Who is eHealthMe?
With medical big data and proven AI algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 600+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).
WARNING, DISCLAIMER, USE FOR PUBLICATION
WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.
DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.
If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.
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