Omeprazole vs. Methotrexate


We compare the side effects and drug effectiveness of Omeprazole and Methotrexate. The study is created by eHealthMe based on reports of 621,382 people who take Omeprazole and Methotrexate, and is updated regularly.

What's eHealthMe?

eHealthMe is a health data analysis company based in Mountain View, California. eHealthMe monitors and analyzes the outcomes of drugs and supplements that are currently on the market. The results are readily available to health care professionals and consumers.

eHealthMe has released original studies on market drugs and worked with leading universities and institutions such as IBM, London Health Science Centre, Mayo Clinic, Northwestern University and VA. eHealthMe studies have now been referenced in over 500 peer-reviewed medical publications.

How we gather our data?

Healthcare data is obtained from a number of sources including the Food and Drug Administration (FDA). This information is aggregated and used to produce personalized reports that patients can reference.

The information that eHealthMe collects includes:

  • Side effects (including severity and how people recover from them)
  • Associated conditions or symptoms
  • Drug effectiveness
  • Demographic data regarding drug use

How the study uses the data?

The study is based on omeprazole and methotrexate sodium (the active ingredients of Omeprazole and Methotrexate, respectively). Other drugs that have the same active ingredients (e.g. generic drugs or brand names) are also considered.

What is Omeprazole?

Omeprazole has active ingredients of omeprazole. It is often used in gastroesophageal reflux disease. (latest outcomes from Omeprazole 224,591 users)

What is Methotrexate?

Methotrexate has active ingredients of methotrexate sodium. It is often used in rheumatoid arthritis. (latest outcomes from Methotrexate 307,853 users)

How to use the study?

Patients can bring a copy of the report to their healthcare provider to ensure that all drug risks and benefits are fully discussed and understood. It is recommended that patients use the information presented as a part of a broader decision-making process.

On Mar, 04, 2019

621,382 people who take Omeprazole and Methotrexate are studied.

Number of reports submitted per year:

Omeprazole vs Methotrexate drug comparison reports.

Drugs in this study:

  • Methotrexate (methotrexate sodium)
  • Omeprazole (omeprazole)

Most common side effects:

  1. Drug Ineffective
  2. Arthralgia (joint pain)
  3. Pain
  4. Nausea (feeling of having an urge to vomit)
  5. Fatigue (feeling of tiredness)
  6. Injection Site Pain
  7. Headache (pain in head)
  8. Pyrexia (fever)
  9. Pneumonia
  10. Pain In Extremity
  1. Nausea (feeling of having an urge to vomit)
  2. Diarrhoea
  3. Dyspnoea (difficult or laboured respiration)
  4. Fatigue (feeling of tiredness)
  5. Drug Ineffective
  6. Pain
  7. Vomiting
  8. Headache (pain in head)
  9. Chronic Kidney Disease
  10. Dizziness

Most common side effects experienced by people in long term use:

  1. Drug Ineffective
  2. Nausea (feeling of having an urge to vomit)
  3. Pneumonia
  4. Arthralgia (joint pain)
  5. Pyrexia (fever)
  6. Fatigue (feeling of tiredness)
  7. Pain
  8. Dyspnoea (difficult or laboured respiration)
  9. Drug Intolerance (drug sensitivity)
  10. Diarrhoea
  1. Chronic Kidney Disease
  2. Renal Failure (kidney dysfunction)
  3. Death
  4. Tubulointerstitial Nephritis (a form of nephritis affecting the interstitium of the kidneys surrounding the tubules)
  5. Depression
  6. Anxiety
  7. Diarrhoea
  8. Drug Ineffective
  9. Hypomagnesaemia (electrolyte disturbance in which there is an abnormally low level of magnesium in the blood)
  10. Fall

Drug effectiveness:

  • not at all: 5.92 %
  • somewhat: 25.78 %
  • moderate: 34.38 %
  • high: 25.91 %
  • very high: 8.01 %
  • not at all: 2.7199999999999998 %
  • somewhat: 14.25 %
  • moderate: 27.16 %
  • high: 37.12 %
  • very high: 18.75 %

Do you take Omeprazole or Methotrexate?

You are not alone:

Related publications that referenced our studies

Related studies:

Compare Omeprazole with similar drugs
Compare Methotrexate with similar drugs

Recent updates

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WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only, and has not been supported by scientific studies or clinical trials unless otherwise stated. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

You may report adverse side effects to the FDA at or 1-800-FDA-1088 (1-800-332-1088).

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.