Ritalin-sr vs. Modafinil: side effect and effectiveness comparison - a phase IV clinical study
Summary:
We compare the side effects and drug effectiveness of Ritalin-sr and Modafinil. The phase IV clinical study is created by eHealthMe based on reports (from sources including the FDA) of 101,648 people who take Ritalin-sr and Modafinil, and is updated regularly. You can use the study as a second opinion to make health care decisions.
Phase IV trials are used to detect adverse drug outcomes and monitor drug effectiveness in the real world. With medical big data and AI algorithms, eHealthMe is running millions of phase IV trials and makes the results available to the public. Our original studies have been referenced on 600+ medical publications including The Lancet, Mayo Clinic Proceedings, and Nature.
101,648 people who take Ritalin-sr and Modafinil are studied.
What is Ritalin-sr?
Ritalin-sr has active ingredients of methylphenidate hydrochloride. It is often used in attention deficit hyperactivity disorder. eHealthMe is studying from 396 Ritalin-sr users for its effectiveness, alternative drugs and more.
What is Modafinil?
Modafinil has active ingredients of modafinil. It is often used in narcolepsy. eHealthMe is studying from 17,539 Modafinil users for its effectiveness, alternative drugs and more.
Number of reports submitted per year:
Drugs being compared in this study:
- Ritalin-Sr (methylphenidate hydrochloride)
- Modafinil (modafinil)
Most common side effects of the drugs, overall:
Most common side effects of the drugs, in long term (1+ years) use:
Drug effectiveness:
Ritalin-Sr:
- not at all: 1.9300000000000002 %
- somewhat: 15.61 %
- moderate: 36.08 %
- high: 34.83 %
- very high: 11.56 %
Modafinil:
- not at all: 2.63 %
- somewhat: 17.48 %
- moderate: 33.67 %
- high: 32.59 %
- very high: 13.63 %
Want to compare Ritalin-sr with Modafinil?
Personalize this study to your gender and age (0-99+).How to use the study?
You can discuss the study with your doctor, to ensure that all drug risks and benefits are fully discussed and understood.
Related publications that referenced our studies
- Coskun M, Adak I, "Excessive and frequent menstrual bleeding with methylphenidate in an adolescent girl with attention-deficit hyperactivity disorder", Journal of clinical psychopharmacology, 2017 Oct .
- Yektas ?, Samurcu ND, Tufan AE, "Loss of Eyebrows (Madarosis) After Use of Long-Acting Methylphenidate: Case Report", Journal of Clinical Psychopharmacology, 2017 Aug .
- Ersoy MA, Ersoy HT, "Manic symptoms associated with isotretinoin and methylphenidate combination: a case report", Klinik Psikofarmakoloji Bülteni-Bulletin of Clinical Psychopharmacology, 2014 Sep .
- Coskun M, Adak I, Akaltun I, "Bilateral gynecomastia in a preadolescent boy while under treatment with methylphenidate and paroxetine", Journal of clinical psychopharmacology, 2014 Aug .
- Lopes E, Pereira D, da Silva Behrens NS, de Almeida Fonseca H, Calvancanti PO, de Araújo Lima TF, Pradella-Hallinan M, Castro J, Tufik S, Coelho FM, "Cataplexy as a side effect of modafinil in a patient without narcolepsy", Sleep Science, 2014 Mar .
- Adak, I., & Coskun, M. , "Symptomatic cholelithiasis associated with combined use of methylphenidate and fluoxetine in an otherwise healthy adolescent girl", Psychiatry and Clinical Psychopharmacology, 2014 Jan .
- Coskun, M., & Adak, I. , "Excessive and frequent menstrual bleeding with methylphenidate in an adolescent girl with attention-deficit hyperactivity disorder", Journal of clinical psychopharmacology, 2014 Jan .
- Yalcin O, Aslan AA, Sari BA, Turkbay T, "Possible methylphenidate related hoarseness and disturbances of voice quality: two pediatric cases", Klinik Psikofarmakoloji Bülteni-Bulletin of Clinical Psychopharmacology, 2012 Sep .
- Lufi D, Bucherman M, Akita M, Cohen R, Sibani C, "The effect of methylphenidate on speech patterns of children with attention deficit disorder", Journal of Behavioral Health, 2012 Jan .
Related studies
Alternative drugs to, pros and cons of:
- Ritalin-sr (262 reports)
- Modafinil (16,747 reports)
Common Modafinil side effects:
- Abdominal discomfort: 243 reports
- Abdominal pain: 172 reports
- Abdominal pain upper: 204 reports
- Abnormal dreams: 151 reports
- Aggression: 110 reports
- Agitation (state of anxiety or nervous excitement): 167 reports
- Anaemia (lack of blood): 107 reports
- Appetite - decreased (decreased appetite occurs when you have a reduced desire to eat): 320 reports
- Appetite - increased (increased appetite is when you want to eat much more often or in larger quantities than your body requires): 113 reports
- Arrhythmias (irregular heartbeat): 132 reports
- Arthritis (form of joint disorder that involves inflammation of one or more joints): 180 reports
- Asthma: 160 reports
- Atrial fibrillation/flutter (atrial fibrillation and flutter are abnormal heart rhythms in which the atria, or upper chambers of the heart, are out of sync with the ventricles): 107 reports
- Back pain: 382 reports
- Balance disorder: 375 reports
- Bedwetting: 110 reports
- Bipolar disorder (mood disorder): 114 reports
- Breathing difficulty: 491 reports
- Bronchitis (inflammation of the mucous membrane in the bronchial tubes): 190 reports
- Cataplexy (loss of muscle tone accompanied by full conscious awareness): 265 reports
- Chest pain: 365 reports
- Chills (felling of cold): 131 reports
- Chronic obstructive pulmonary disease (a progressive disease that makes it hard to breathe): 105 reports
- Cognitive disorder (mental health disorders affects learning, memory, perception, and problem solving): 153 reports
- Completed suicide (act of taking one's own life): 117 reports
- Condition: 409 reports
- Confusion: 113 reports
- Confusional state: 294 reports
- Constipation: 245 reports
- Cough: 335 reports
- Crying: 104 reports
- Death: 153 reports
- Dehydration (dryness resulting from the removal of water): 186 reports
- Depressed mood: 118 reports
- Depression: 1,049 reports
- Diabetes: 135 reports
- Diarrhea: 529 reports
- Disturbance in attention: 154 reports
- Dizziness: 897 reports
- Drowsiness: 887 reports
- Drug hypersensitivity: 239 reports
- Drug ineffective: 1,000 reports
- Drug intolerance (drug sensitivity): 124 reports
- Dry mouth: 164 reports
- Fall: 1,115 reports
- Fatigue (feeling of tiredness): 1,589 reports
- Feeling hot: 121 reports
- Fever: 290 reports
- Fibromyalgia (a long-term condition which causes pain all over the body): 126 reports
- Gait disturbance: 515 reports
- Gastroesophageal reflux disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 229 reports
- Gastrointestinal disorder (functional problems of gastrointestinal tract): 117 reports
- Hair loss: 228 reports
- Hallucinations (sensations that appear real but are created by your mind): 182 reports
- Headache (pain in head): 1,106 reports
- Head injury: 273 reports
- Heart palpitations (feelings or sensations that your heart is pounding or racing): 218 reports
- Heart rate increased: 169 reports
- High blood cholesterol: 165 reports
- High blood pressure: 1,101 reports
- Hospitalisation: 185 reports
- Hyperhidrosis (abnormally increased sweating): 247 reports
- Hypersensitivity: 245 reports
- Hypoaesthesia (reduced sense of touch or sensation): 378 reports
- Hypotension (abnormally low blood pressure): 230 reports
- Indigestion: 134 reports
- Infection: 125 reports
- Influenza like illness: 129 reports
- Insomnia (sleeplessness): 616 reports
- Intervertebral disc protrusion (spinal disc protrusion): 129 reports
- Irritability: 162 reports
- Itching: 275 reports
- Joint pain: 392 reports
- Kidney stones: 197 reports
- Loss of consciousness: 233 reports
- Malaise (a feeling of general discomfort or uneasiness): 501 reports
- Memory loss: 611 reports
- Migraine (headache): 383 reports
- Mobility decreased (ability to move is reduced): 192 reports
- Multiple sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath): 394 reports
- Multiple sclerosis relapse (reoccurrence of a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath): 503 reports
- Muscle aches (muscle pain): 144 reports
- Muscle spasms (muscle contraction): 400 reports
- Muscle spasticity (tight or stiff muscles and an inability to control those muscles): 110 reports
- Musculoskeletal stiffness (stiffness of the body's muscles, joints, tendons, ligaments and nerves): 137 reports
- Nasopharyngitis (inflammation of the nasopharynx): 348 reports
- Nausea (feeling of having an urge to vomit): 1,234 reports
- Nausea and vomiting: 576 reports
- Neck pain: 125 reports
- Nervousness: 110 reports
- Neuropathy peripheral (surface nerve damage): 150 reports
- Nightmares (unpleasant dreams): 128 reports
- Night sweats (sweating in night): 101 reports
- Oedema peripheral (superficial swelling): 106 reports
- Oropharyngeal pain: 117 reports
- Osteoarthritis (a joint disease caused by cartilage loss in a joint): 114 reports
- Pain: 718 reports
- Pain in extremity: 314 reports
- Panic disorder: 131 reports
- Paraesthesia (sensation of tingling, tickling, prickling, pricking, or burning of a person's skin with no apparent long-term physical effect): 351 reports
- Peripheral swelling: 190 reports
- Pneumonia: 352 reports
- Pre-existing condition improved: 488 reports
- Psychotic disorder: 110 reports
- Rashes (redness): 371 reports
- Restless leg syndrome (a powerful urge to move your legs): 160 reports
- Road traffic accident: 109 reports
- Seizures (abnormal excessive or synchronous neuronal activity in the brain): 233 reports
- Sepsis (a severe blood infection that can lead to organ failure and death): 119 reports
- Sinusitis (inflammation of sinus): 258 reports
- Skin blushing/flushing (a sudden reddening of the face, neck): 283 reports
- Sleep apnea syndrome: 604 reports
- Sleep disorder: 119 reports
- Sleep walking (walking during sleep): 172 reports
- Snoring: 117 reports
- Speech disorder: 107 reports
- Speech impairment (adult) (inability to speak (adult)): 114 reports
- Stress and anxiety: 1,137 reports
- Suicidal ideation: 481 reports
- Surgery: 255 reports
- Swelling: 126 reports
- The flu (the flu is caused by an influenza virus): 183 reports
- Therapeutic response decreased (less preventive response): 116 reports
- Therapeutic response unexpected: 329 reports
- Tremor (trembling or shaking movements in one or more parts of your body): 399 reports
- Urinary incontinence (inability to control the flow of urine and involuntary urination): 130 reports
- Urinary tract infection: 484 reports
- Urticaria (rash of round, red welts on the skin that itch intensely): 142 reports
- Vision blurred: 204 reports
- Visual impairment: 182 reports
- Weakness: 844 reports
- Weight decreased: 688 reports
- Weight increased: 308 reports
- Weight loss: 109 reports
- White blood cell count decreased: 122 reports
How the study uses the data?
The study is based on methylphenidate hydrochloride and modafinil (the active ingredients of Ritalin-sr and Modafinil, respectively). Other drugs that have the same active ingredients (e.g. generic drugs or brand names) are also considered. Dosage of drugs is not considered in the study.
Who is eHealthMe?
With medical big data and proven AI algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 600+ medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).
WARNING, DISCLAIMER, USE FOR PUBLICATION
WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.
DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.
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