Sinequan vs. Valproic acid: side effect and effectiveness comparison - a phase IV clinical study
Summary:
We compare the side effects and drug effectiveness of Sinequan and Valproic acid. The phase IV clinical study is created by eHealthMe based on reports (from sources including the FDA) of 65,968 people who take Sinequan and Valproic acid, and is updated regularly. You can use the study as a second opinion to make health care decisions.
Phase IV trials are used to detect adverse drug outcomes and monitor drug effectiveness in the real world. With medical big data and AI algorithms, eHealthMe is running millions of phase IV trials and makes the results available to the public. Our original studies have been referenced on 600+ medical publications including The Lancet, Mayo Clinic Proceedings, and Nature.
65,968 people who take Sinequan and Valproic acid are studied.
What is Sinequan?
Sinequan has active ingredients of doxepin hydrochloride. It is often used in depression. eHealthMe is studying from 1,796 Sinequan users for its effectiveness, alternative drugs and more.
What is Valproic acid?
Valproic acid has active ingredients of valproic acid. It is often used in epilepsy. eHealthMe is studying from 31,102 Valproic acid users for its effectiveness, alternative drugs and more.
Number of reports submitted per year:
Drugs being compared in this study:
- Sinequan (doxepin hydrochloride)
- Valproic Acid (valproic acid)
Most common side effects of the drugs, overall:
Most common side effects of the drugs, in long term (1+ years) use:
Drug effectiveness:
Sinequan:
- not at all: 6.9 %
- somewhat: 26.5 %
- moderate: 26.73 %
- high: 30.51 %
- very high: 9.35 %
Valproic Acid:
- not at all: 5.78 %
- somewhat: 22.45 %
- moderate: 29.59 %
- high: 26.19 %
- very high: 15.99 %
Want to compare Sinequan with Valproic acid?
Personalize this study to your gender and age (0-99+).How to use the study?
You can discuss the study with your doctor, to ensure that all drug risks and benefits are fully discussed and understood.
Related publications that referenced our studies
- Gupta E, Kunjal R, Cury JD, "Severe hyponatremia due to valproic acid toxicity", Journal of clinical medicine research, 2015 Jan .
- Hwabejire JO, Lu J, Liu B, Li Y, Halaweish I, Alam HB, "Valproic acid for the treatment of hemorrhagic shock: a dose-optimization study", journal of surgical research, 2014 Jan .
Related studies
Alternative drugs to, pros and cons of:
- Sinequan (1,705 reports)
- Valproic acid (30,758 reports)
Common Sinequan side effects:
- Drug ineffective: 144 reports
- Pain: 138 reports
- Fatigue (feeling of tiredness): 131 reports
- Diarrhea: 125 reports
- Depression: 119 reports
Browse all side effects of Sinequan:
a b c d e f g h i j k l m n o p q r s t u v w x y zCommon Valproic acid side effects:
- Drug ineffective: 2,811 reports
- Seizures (abnormal excessive or synchronous neuronal activity in the brain): 1,509 reports
- Depression: 1,471 reports
- Drowsiness: 1,302 reports
- Fever: 1,151 reports
- Thrombocytopenia (decrease of platelets in blood): 1,031 reports
- Fatigue (feeling of tiredness): 1,022 reports
Browse all side effects of Valproic acid:
a b c d e f g h i j k l m n o p q r s t u v w x y zHow the study uses the data?
The study is based on doxepin hydrochloride and valproic acid (the active ingredients of Sinequan and Valproic acid, respectively). Other drugs that have the same active ingredients (e.g. generic drugs or brand names) are also considered. Dosage of drugs is not considered in the study.
Who is eHealthMe?
With medical big data and proven AI algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 600+ medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).
WARNING, DISCLAIMER, USE FOR PUBLICATION
WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.
DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.
If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.
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