Tylenol w/ codeine vs. Diclofenac sodium: side effect and effectiveness comparison - a phase IV clinical study
Summary:
We compare the side effects and drug effectiveness of Tylenol w/ codeine and Diclofenac sodium. The phase IV clinical study is created by eHealthMe based on reports (from sources including the FDA) of 162,782 people who take Tylenol w/ codeine and Diclofenac sodium, and is updated regularly. You can use the study as a second opinion to make health care decisions.
Phase IV trials are used to detect adverse drug outcomes and monitor drug effectiveness in the real world. With medical big data and AI algorithms, eHealthMe is running millions of phase IV trials and makes the results available to the public. Our original studies have been referenced on 600+ medical publications including The Lancet, Mayo Clinic Proceedings, and Nature.
162,782 people who take Tylenol w/ codeine and Diclofenac sodium are studied.
What is Tylenol w/ codeine?
Tylenol w/ codeine has active ingredients of acetaminophen; codeine phosphate. It is often used in pain. eHealthMe is studying from 8,098 Tylenol w/ codeine users for its effectiveness, alternative drugs and more.
What is Diclofenac sodium?
Diclofenac sodium has active ingredients of diclofenac sodium. It is often used in arthritis. eHealthMe is studying from 34,057 Diclofenac sodium users for its effectiveness, alternative drugs and more.
Number of reports submitted per year:

Drugs being compared in this study:
- Diclofenac Sodium (diclofenac sodium)
- Tylenol W/ Codeine (acetaminophen; codeine phosphate)
Most common side effects of the drugs, overall:
Most common side effects of the drugs, in long term (1+ years) use:
Drug effectiveness:
Tylenol W/ Codeine:
- not at all: 4.22 %
- somewhat: 26.72 %
- moderate: 40.31 %
- high: 22.13 %
- very high: 6.61 %
Diclofenac Sodium:
- not at all: 4.58 %
- somewhat: 28.5 %
- moderate: 36.3 %
- high: 23.24 %
- very high: 7.38 %
Want to compare Tylenol w/ codeine with Diclofenac sodium?
Personalize this study to your gender and age (0-99+).How to use the study?
You can discuss the study with your doctor, to ensure that all drug risks and benefits are fully discussed and understood.
Related studies
Alternative drugs to, pros and cons of:
- Tylenol w/ codeine (7,306 reports)
- Diclofenac sodium (32,787 reports)
Common Tylenol w/ codeine side effects:
- Pain: 726 reports
- Stress and anxiety: 574 reports
- Breathing difficulty: 573 reports
- Fatigue (feeling of tiredness): 572 reports
- Headache (pain in head): 506 reports
- Weakness: 481 reports
Browse all side effects of Tylenol w/ codeine:
a b c d e f g h i j k l m n o p q r s t u v w x y zCommon Diclofenac sodium side effects:
- Drug ineffective: 5,365 reports
- Pain: 5,126 reports
- Fatigue (feeling of tiredness): 4,524 reports
- Rashes (redness): 4,000 reports
- Rheumatoid arthritis (a chronic progressive disease causing inflammation in the joints): 3,918 reports
- Hair loss: 3,611 reports
- Systemic lupus erythematosus (an autoimmune disease, which means the body's immune system mistakenly, attacks healthy tissue): 3,445 reports
Browse all side effects of Diclofenac sodium:
a b c d e f g h i j k l m n o p q r s t u v w x y zHow the study uses the data?
The study is based on acetaminophen; codeine phosphate and diclofenac sodium (the active ingredients of Tylenol w/ codeine and Diclofenac sodium, respectively). Other drugs that have the same active ingredients (e.g. generic drugs or brand names) are also considered. Dosage of drugs is not considered in the study.
Who is eHealthMe?
With medical big data and proven AI algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 600+ medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).
WARNING, DISCLAIMER, USE FOR PUBLICATION
WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.
DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.
If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.
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