Xifaxan vs. Nortriptyline hydrochloride: side effect and effectiveness comparison - a phase IV clinical study


We compare the side effects and drug effectiveness of Xifaxan and Nortriptyline hydrochloride. The phase IV clinical study is created by eHealthMe based on reports (from sources including the FDA) of 44,640 people who take Xifaxan and Nortriptyline hydrochloride, and is updated regularly. You can use the study as a second opinion to make health care decisions.

Phase IV trials are used to detect adverse drug outcomes and monitor drug effectiveness in the real world. With medical big data and AI algorithms, eHealthMe is running millions of phase IV trials and makes the results available to the public. Our original studies have been referenced on 600+ medical publications including The Lancet, Mayo Clinic Proceedings, and Nature.

On Sep, 19, 2022

44,640 people who take Xifaxan and Nortriptyline hydrochloride are studied.

What is Xifaxan?

Xifaxan has active ingredients of rifaximin. It is often used in irritable bowel syndrome. eHealthMe is studying from 13,509 Xifaxan users for its effectiveness, alternative drugs and more.

What is Nortriptyline hydrochloride?

Nortriptyline hydrochloride has active ingredients of nortriptyline hydrochloride. It is often used in migraine. eHealthMe is studying from 3,559 Nortriptyline hydrochloride users for its effectiveness, alternative drugs and more.

Number of reports submitted per year:

Xifaxan vs Nortriptyline hydrochloride drug comparison reports.

Drugs being compared in this study:

  • Nortriptyline Hydrochloride (nortriptyline hydrochloride)
  • Xifaxan (rifaximin)

Most common side effects of the drugs, overall:

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Most common side effects of the drugs, in long term (1+ years) use:

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Drug effectiveness:

  • not at all: 7.69 %
  • somewhat: 30.77 %
  • moderate: 29.81 %
  • high: 14.42 %
  • very high: 17.31 %
Nortriptyline Hydrochloride:
  • not at all: 8.63 %
  • somewhat: 28.01 %
  • moderate: 34.44 %
  • high: 21.59 %
  • very high: 7.33 %

Want to compare Xifaxan with Nortriptyline hydrochloride?

Personalize this study to your gender and age (0-99+).

How to use the study?

You can discuss the study with your doctor, to ensure that all drug risks and benefits are fully discussed and understood.

Related studies

Alternative drugs to, pros and cons of:

Common Xifaxan side effects:

Common Nortriptyline hydrochloride side effects:

How the study uses the data?

The study is based on rifaximin and nortriptyline hydrochloride (the active ingredients of Xifaxan and Nortriptyline hydrochloride, respectively). Other drugs that have the same active ingredients (e.g. generic drugs or brand names) are also considered. Dosage of drugs is not considered in the study.

Who is eHealthMe?

With medical big data and proven AI algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 600+ medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).


WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.

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