Zantac vs. Zegerid: side effect and effectiveness comparison - a phase IV clinical study
Summary:
We compare the side effects and drug effectiveness of Zantac and Zegerid. The phase IV clinical study is created by eHealthMe based on reports (from sources including the FDA) of 424,019 people who take Zantac and Zegerid, and is updated regularly. You can use the study as a second opinion to make health care decisions.
Phase IV trials are used to detect adverse drug outcomes and monitor drug effectiveness in the real world. With medical big data and AI algorithms, eHealthMe is running millions of phase IV trials and makes the results available to the public. Our original studies have been referenced on 600+ medical publications including The Lancet, Mayo Clinic Proceedings, and Nature.
424,019 people who take Zantac and Zegerid are studied.
What is Zantac?
Zantac has active ingredients of ranitidine hydrochloride. It is often used in gastroesophageal reflux disease. eHealthMe is studying from 367,146 Zantac users for its effectiveness, alternative drugs and more.
What is Zegerid?
Zegerid has active ingredients of omeprazole; sodium bicarbonate. It is often used in gastroesophageal reflux disease. eHealthMe is studying from 3,168 Zegerid users for its effectiveness, alternative drugs and more.
Number of reports submitted per year:

Drugs being compared in this study:
- Zegerid (omeprazole; sodium bicarbonate)
- Zantac (ranitidine hydrochloride)
Most common side effects of the drugs, overall:
Most common side effects of the drugs, in long term (1+ years) use:
Drug effectiveness:
Zantac:
- not at all: 2.38 %
- somewhat: 23.7 %
- moderate: 38.65 %
- high: 27.34 %
- very high: 7.92 %
Zegerid:
- not at all: 2.48 %
- somewhat: 19.88 %
- moderate: 23.6 %
- high: 34.78 %
- very high: 19.25 %
Want to compare Zantac with Zegerid?
Personalize this study to your gender and age (0-99+).How to use the study?
You can discuss the study with your doctor, to ensure that all drug risks and benefits are fully discussed and understood.
Related studies
Alternative drugs to, pros and cons of:
Common Zantac side effects:
- Prostate cancer: 42,886 reports
- Colon cancer: 38,454 reports
- Renal cell carcinoma (a kidney cancer): 31,691 reports
- Breast cancer: 31,011 reports
- Bladder cancer: 28,922 reports
- Gastric cancer (stomach cancer): 14,090 reports
- Pancreatic carcinoma (pancreatic cancer): 11,333 reports
Browse all side effects of Zantac:
a b c d e f g h i j k l m n o p q r s t u v w x y zCommon Zegerid side effects:
- Chronic kidney disease: 684 reports
- Acute kidney failure: 309 reports
- Drug ineffective: 214 reports
- Pain: 204 reports
- Fatigue (feeling of tiredness): 150 reports
- Stress and anxiety: 139 reports
Browse all side effects of Zegerid:
a b c d e f g h i j k l m n o p q r s t u v w x y zHow the study uses the data?
The study is based on ranitidine hydrochloride and omeprazole; sodium bicarbonate (the active ingredients of Zantac and Zegerid, respectively). Other drugs that have the same active ingredients (e.g. generic drugs or brand names) are also considered. Dosage of drugs is not considered in the study.
Who is eHealthMe?
With medical big data and proven AI algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 600+ medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).
WARNING, DISCLAIMER, USE FOR PUBLICATION
WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.
DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.
If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.
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