Dupuytren's contracture and drugs of ingredients of adalimumab - a phase IV clinical study of FDA data


Summary:

Dupuytren's contracture is found among people who take drugs with ingredients of adalimumab, especially for people who are male, 60+ old , have been taking the drugs for 2 - 5 years. This phase IV clinical study is created by eHealthMe based on reports of 662,238 people who have side effects when taking drugs with ingredients of adalimumab from the FDA, and is updated regularly.

Drug(s) considered in the study (i.e. both brand name and generic drugs): Humira.

Phase IV trials are used to detect adverse drug outcomes and monitor drug effectiveness in the real world. With medical big data and AI algorithms, eHealthMe is running millions of phase IV trials and makes the results available to the public. Our original studies have been referenced on 600+ medical publications including The Lancet, Mayo Clinic Proceedings, and Nature.


On Sep, 24, 2022

662,238 people reported to have side effects when taking drugs with ingredients of adalimumab.
Among them, 68 people (0.01%) have Dupuytren's contracture


What is Dupuytren's contracture?

Dupuytren's contracture (thickening of the fibrous tissue layer underneath the skin of the palm and fingers) is found to be associated with 459 drugs and 212 conditions by eHealthMe.

Number of reports submitted per year:

Could drugs with ingredients of adalimumab cause Dupuytren's contracture?

Time on drugs with ingredients of adalimumab when people have Dupuytren's contracture *:

  • < 1 month: 0.0 %
  • 1 - 6 months: 10 %
  • 6 - 12 months: 25 %
  • 1 - 2 years: 15 %
  • 2 - 5 years: 35 %
  • 5 - 10 years: 15 %
  • 10+ years: 0.0 %

Gender of people who have Dupuytren's contracture when taking drugs with ingredients of adalimumab *:

  • female: 44.12 %
  • male: 55.88 %

Age of people who have Dupuytren's contracture when taking drugs with ingredients of adalimumab *:

  • 0-1: 0.0 %
  • 2-9: 0.0 %
  • 10-19: 0.0 %
  • 20-29: 0.0 %
  • 30-39: 2.94 %
  • 40-49: 11.76 %
  • 50-59: 32.35 %
  • 60+: 52.94 %

Conditions people have *:

  1. Psoriatic Arthropathy (inflammation of the skin and joints with kin condition which typically causes patches (plaques) of red, scaly skin to develop): 17 people, 25.00%
  2. Psoriasis (immune-mediated disease that affects the skin): 14 people, 20.59%
  3. High Blood Pressure: 10 people, 14.71%
  4. Pain: 5 people, 7.35%
  5. Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 4 people, 5.88%
  6. Hypersensitivity: 3 people, 4.41%
  7. Diabetes: 3 people, 4.41%
  8. Ankylosing Spondylitis (type of arthritis affecting the spine): 3 people, 4.41%
  9. Arthritis (form of joint disorder that involves inflammation of one or more joints): 3 people, 4.41%
  10. Hypothyroidism (abnormally low activity of the thyroid gland, resulting in retardation of growth and mental development): 3 people, 4.41%

Other drugs people take *:

  1. Enbrel: 8 people, 11.76%
  2. Synthroid: 6 people, 8.82%
  3. Vitamin D3: 5 people, 7.35%
  4. Methotrexate: 5 people, 7.35%
  5. Zyrtec: 4 people, 5.88%
  6. Percocet: 4 people, 5.88%
  7. Zantac: 4 people, 5.88%
  8. Amlodipine: 4 people, 5.88%
  9. Vitamin D: 4 people, 5.88%
  10. Selenium: 4 people, 5.88%

Other side effects people have besides Dupuytren's contracture *:

  1. Joint Pain: 13 people, 19.12%
  2. Drug Ineffective: 9 people, 13.24%
  3. Hypoaesthesia (reduced sense of touch or sensation): 9 people, 13.24%
  4. Gait Disturbance: 7 people, 10.29%
  5. Pain In Extremity: 7 people, 10.29%
  6. Carpal Tunnel Syndrome (nerve compression at wrist results numbness weakness, pain , swelling): 6 people, 8.82%
  7. Depression: 6 people, 8.82%
  8. Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 6 people, 8.82%
  9. Nausea (feeling of having an urge to vomit): 6 people, 8.82%
  10. Pain: 6 people, 8.82%

* Approximation only. Some reports may have incomplete information.


How to use the study?

You can discuss the study with your doctor, to ensure that all drug risks and benefits are fully discussed and understood.

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Drugs with ingredients of adalimumab, their effectiveness, alternatives and more:

How the study uses the data?

The study uses data from the FDA. It is based on adalimumab. All drugs that have the same active ingredients (e.g. brand name and generic drugs) are considered. Dosage of drugs is not considered in the study.

Who is eHealthMe?

With medical big data and proven AI algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 600+ medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

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