Multiple sclerosis and drugs of ingredients of buprenorphine hydrochloride; naloxone hydrochloride - a phase IV clinical study of FDA data

---

---

Number of reports submitted per year:

Time on drugs with ingredients of buprenorphine hydrochloride; naloxone hydrochloride when people have Multiple sclerosis *:

• < 1 month: 50 %
• 1 - 6 months: 0.0 %
• 6 - 12 months: 50 %
• 1 - 2 years: 0.0 %
• 2 - 5 years: 0.0 %
• 5 - 10 years: 0.0 %
• 10+ years: 0.0 %

Gender of people who have Multiple sclerosis when taking drugs with ingredients of buprenorphine hydrochloride; naloxone hydrochloride *:

• female: 73.33 %
• male: 26.67 %

Age of people who have Multiple sclerosis when taking drugs with ingredients of buprenorphine hydrochloride; naloxone hydrochloride *:

• 0-1: 0.0 %
• 2-9: 0.0 %
• 10-19: 0.0 %
• 20-29: 18.18 %
• 30-39: 59.09 %
• 40-49: 13.64 %
• 50-59: 9.09 %
• 60+: 0.0 %

Conditions people have *:

1. Drug Dependence: 7 people, 21.88%
2. Pain: 4 people, 12.50%
3. Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 3 people, 9.38%
4. Relapsing-Remitting Multiple Sclerosis (reoccurrence of an inflammatory disease in which the insulating covers of nerve cells in the brain and spinal cord are damaged): 3 people, 9.38%
5. Depression: 3 people, 9.38%
6. Urinary Incontinence (inability to control the flow of urine and involuntary urination): 2 people, 6.25%
7. Migraine (headache): 2 people, 6.25%
8. Generalized Anxiety Disorder (excessive, uncontrollable, unexplained and often irrational worry): 1 person, 3.12%
9. High Blood Cholesterol: 1 person, 3.12%
10. Herpes Simplex (herpes simplex is a common viral infection): 1 person, 3.12%

Other drugs people take *:

1. Benadryl: 6 people, 18.75%
2. Tylenol: 5 people, 15.62%
3. Gravol: 3 people, 9.38%
4. Rebif: 3 people, 9.38%
5. Zofran: 2 people, 6.25%
6. Myrbetriq: 2 people, 6.25%
7. Flonase: 2 people, 6.25%
8. Subutex: 2 people, 6.25%
9. Tysabri: 2 people, 6.25%
10. Vesicare: 2 people, 6.25%

Other side effects people have besides Multiple sclerosis *:

1. Fatigue (feeling of tiredness): 11 people, 34.38%
2. Stress And Anxiety: 8 people, 25.00%
3. Epilepsy (common and diverse set of chronic neurological disorders characterized by seizures): 5 people, 15.62%
4. Pain: 5 people, 15.62%
5. Dental Caries: 5 people, 15.62%
6. Convulsion (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled shaking of the body): 5 people, 15.62%
7. Balance Disorder: 5 people, 15.62%
8. Blindness: 5 people, 15.62%
9. Nausea And Vomiting: 5 people, 15.62%
10. Drowsiness: 4 people, 12.50%

---