Gastrointestinal inflammation and drugs of ingredients of cobalamin - a phase IV clinical study of FDA data


Summary:

Gastrointestinal inflammation is found among people who take drugs with ingredients of cobalamin, especially for people who are female, 60+ old , have been taking the drugs for 2 - 5 years. This phase IV clinical study is created by eHealthMe based on reports of 86,847 people who have side effects when taking drugs with ingredients of cobalamin from the FDA, and is updated regularly.

Drug(s) considered in the study (i.e. both brand name and generic drugs): Vitamin b12.

With medical big data and AI algorithms, eHealthMe enables everyone to run phase IV clinical trial to detect adverse drug outcomes and monitor effectiveness. Our original studies have been referenced on 600+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Most recently, phase IV clinial trails for COVID 19 vaccines have been added, check here.


On Jun, 25, 2022

86,847 people reported to have side effects when taking drugs with ingredients of cobalamin.
Among them, 142 people (0.16%) have Gastrointestinal inflammation


What is Gastrointestinal inflammation?

Gastrointestinal inflammation (inflammation of stomach and intestine) is found to be associated with 755 drugs and 490 conditions by eHealthMe.

Number of reports submitted per year:

Could drugs with ingredients of cobalamin cause Gastrointestinal inflammation?

Time on drugs with ingredients of cobalamin when people have Gastrointestinal inflammation *:

  • < 1 month: 0.0 %
  • 1 - 6 months: 0.0 %
  • 6 - 12 months: 0.0 %
  • 1 - 2 years: 0.0 %
  • 2 - 5 years: 100 %
  • 5 - 10 years: 0.0 %
  • 10+ years: 0.0 %

Gender of people who have Gastrointestinal inflammation when taking drugs with ingredients of cobalamin *:

  • female: 72.31 %
  • male: 27.69 %

Age of people who have Gastrointestinal inflammation when taking drugs with ingredients of cobalamin *:

  • 0-1: 0.0 %
  • 2-9: 1.04 %
  • 10-19: 3.12 %
  • 20-29: 7.29 %
  • 30-39: 11.46 %
  • 40-49: 18.75 %
  • 50-59: 18.75 %
  • 60+: 39.58 %

Conditions people have *:

  1. Crohn's Disease (condition that causes inflammation of the gastrointestinal tract): 118 people, 83.10%
  2. High Blood Pressure: 14 people, 9.86%
  3. Pain: 13 people, 9.15%
  4. Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 10 people, 7.04%
  5. Ulcerative Colitis (inflammatory bowel disease (ibd). it causes swelling, ulcerations, and loss of function of the large intestine): 9 people, 6.34%
  6. Primary Myelofibrosis (primary disorder of the bone marrow): 8 people, 5.63%
  7. Rickets (softening of bones): 8 people, 5.63%
  8. Infection: 8 people, 5.63%
  9. Depression: 7 people, 4.93%
  10. Osteoporosis (bones weak and more likely to break): 7 people, 4.93%

Other drugs people take *:

  1. Humira: 85 people, 59.86%
  2. Vitamin D: 32 people, 22.54%
  3. Calcium: 20 people, 14.08%
  4. Vitamin D3: 17 people, 11.97%
  5. Pantoprazole: 14 people, 9.86%
  6. Vitamin C: 14 people, 9.86%
  7. Imuran: 13 people, 9.15%
  8. Tylenol: 12 people, 8.45%
  9. Inflectra: 11 people, 7.75%
  10. Symbicort: 10 people, 7.04%

Other side effects people have besides Gastrointestinal inflammation *:

  1. Diarrhea: 45 people, 31.69%
  2. Crohn's Disease (condition that causes inflammation of the gastrointestinal tract): 44 people, 30.99%
  3. Abdominal Pain: 44 people, 30.99%
  4. Intestinal Obstruction: 32 people, 22.54%
  5. Drug Ineffective: 20 people, 14.08%
  6. Constipation: 19 people, 13.38%
  7. Itching: 18 people, 12.68%
  8. Rashes (redness): 18 people, 12.68%
  9. Weight Decreased: 17 people, 11.97%
  10. Breathing Difficulty: 17 people, 11.97%

* Approximation only. Some reports may have incomplete information.


How to use the study?

You can discuss the study with your doctor, to ensure that all drug risks and benefits are fully discussed and understood.

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Drugs with ingredients of cobalamin, their effectiveness, alternatives and more:

How the study uses the data?

The study uses data from the FDA. It is based on cobalamin. All drugs that have the same active ingredients (e.g. brand name and generic drugs) are considered. Dosage of drugs is not considered in the study.

Who is eHealthMe?

With medical big data and proven AI algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 600+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.

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