Dupuytren's contracture and drugs of ingredients of collagenase clostridium histolyticum - a phase IV clinical study of FDA data
Dupuytren's contracture is found among people who take drugs with ingredients of collagenase clostridium histolyticum, especially for people who are male, 60+ old , have been taking the drugs for < 1 month. This phase IV clinical study is created by eHealthMe based on reports of 4,549 people who have side effects when taking drugs with ingredients of collagenase clostridium histolyticum from the FDA, and is updated regularly.
Drug(s) considered in the study (i.e. both brand name and generic drugs): Xiaflex.
With medical big data and AI algorithms, eHealthMe enables everyone to run phase IV clinical trial to detect adverse drug outcomes and monitor effectiveness. Our original studies have been referenced on 600+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Most recently, phase IV clinial trails for COVID 19 vaccines have been added, check here.
4,549 people reported to have side effects when taking drugs with ingredients of collagenase clostridium histolyticum.
Among them, 137 people (3.01%) have Dupuytren's contracture
What is Dupuytren's contracture?
Dupuytren's contracture (thickening of the fibrous tissue layer underneath the skin of the palm and fingers) is found to be associated with 435 drugs and 194 conditions by eHealthMe.
Number of reports submitted per year:
Time on drugs with ingredients of collagenase clostridium histolyticum when people have Dupuytren's contracture *:
- < 1 month: 94.87 %
- 1 - 6 months: 5.13 %
- 6 - 12 months: 0.0 %
- 1 - 2 years: 0.0 %
- 2 - 5 years: 0.0 %
- 5 - 10 years: 0.0 %
- 10+ years: 0.0 %
Gender of people who have Dupuytren's contracture when taking drugs with ingredients of collagenase clostridium histolyticum *:
- female: 29.32 %
- male: 70.68 %
Age of people who have Dupuytren's contracture when taking drugs with ingredients of collagenase clostridium histolyticum *:
- 0-1: 0.0 %
- 2-9: 0.0 %
- 10-19: 0.0 %
- 20-29: 1.75 %
- 30-39: 3.51 %
- 40-49: 1.75 %
- 50-59: 26.32 %
- 60+: 66.67 %
Conditions people have *:
- High Blood Cholesterol: 5 people, 3.65%
- High Blood Pressure: 5 people, 3.65%
- Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 3 people, 2.19%
- Hypothyroidism (abnormally low activity of the thyroid gland, resulting in retardation of growth and mental development): 3 people, 2.19%
- Breast Cancer: 2 people, 1.46%
- Mood Swings (an extreme or rapid change in mood): 2 people, 1.46%
- Migraine (headache): 2 people, 1.46%
- Type 1 Diabetes: 2 people, 1.46%
- Type 2 Diabetes: 1 person, 0.73%
- Insomnia (sleeplessness): 1 person, 0.73%
Other drugs people take *:
- Fish Oil: 4 people, 2.92%
- Zantac: 3 people, 2.19%
- Synthroid: 2 people, 1.46%
- Sertraline: 2 people, 1.46%
- Ibrance: 2 people, 1.46%
- Amlodipine: 2 people, 1.46%
- Pantoprazole: 2 people, 1.46%
- Celexa: 2 people, 1.46%
- Hyzaar: 1 person, 0.73%
- Hydrocodone Bitartrate And Ibuprofen: 1 person, 0.73%
Other side effects people have besides Dupuytren's contracture *:
- Drug Ineffective: 77 people, 56.20%
- Disease Recurrence: 34 people, 24.82%
- Injection Site Pain: 20 people, 14.60%
- Pain: 15 people, 10.95%
- Pain In Extremity: 13 people, 9.49%
- Head Injury: 10 people, 7.30%
- Peripheral Swelling: 10 people, 7.30%
- Cuts And Puncture Wounds: 7 people, 5.11%
- Injection Site Swelling: 6 people, 4.38%
- Tendon Rupture (tear of tendon): 6 people, 4.38%
* Approximation only. Some reports may have incomplete information.
How to use the study?
You can discuss the study with your doctor, to ensure that all drug risks and benefits are fully discussed and understood.
Drugs with ingredients of collagenase clostridium histolyticum, their effectiveness, alternatives and more:
How the study uses the data?
The study uses data from the FDA. It is based on collagenase clostridium histolyticum. All drugs that have the same active ingredients (e.g. brand name and generic drugs) are considered. Dosage of drugs is not considered in the study.
Who is eHealthMe?
With medical big data and proven AI algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 600+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).
WARNING, DISCLAIMER, USE FOR PUBLICATION
WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.
DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.
If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.
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