Subdural empyema and drugs of ingredients of diclofenac sodium - a phase IV clinical study of FDA data


Subdural empyema is reported only by a few people who take drugs with ingredients of diclofenac sodium. This phase IV clinical study analyzes 120,496 people who have side effects while taking drugs with ingredients of diclofenac sodium from the the FDA. Among them, 5 have Subdural empyema. Find out below who they are, when they have Subdural empyema and more.

Drug(s) considered in the study (i.e. both brand name and generic drugs): Diclofenac sodium, Dyloject, Pennsaid, Solaraze, Voltaren, Voltaren arthritis pain, Voltaren-xr.

Phase IV trials are used to detect adverse drug outcomes and monitor drug effectiveness in the real world. With medical big data and AI algorithms, eHealthMe is running millions of phase IV trials and makes the results available to the public. Our original studies have been referenced on 600+ medical publications including The Lancet, Mayo Clinic Proceedings, and Nature.

On Feb, 07, 2023

120,496 people reported to have side effects when taking drugs with ingredients of diclofenac sodium.
Among them, 5 people (0.0%) have Subdural empyema

What is Subdural empyema?

Subdural empyema (collection of supportive material between the dura mater and arachnoids surrounding the brain) is found to be associated with 138 drugs and 60 conditions by eHealthMe.

Number of reports submitted per year:

Could drugs with ingredients of diclofenac sodium cause Subdural empyema?

Gender of people who have Subdural empyema when taking drugs with ingredients of diclofenac sodium *:

  • female: 0.0 %
  • male: 100 %

Age of people who have Subdural empyema when taking drugs with ingredients of diclofenac sodium *:

  • 0-1: 0.0 %
  • 2-9: 0.0 %
  • 10-19: 0.0 %
  • 20-29: 0.0 %
  • 30-39: 0.0 %
  • 40-49: 0.0 %
  • 50-59: 60 %
  • 60+: 40 %

Conditions people have *:

  1. Fever: 3 people, 60.00%
  2. Thrombocytopenia (decrease of platelets in blood): 2 people, 40.00%
  3. Prostate Cancer Metastatic: 2 people, 40.00%
  4. Pain In Extremity: 2 people, 40.00%
  5. Muscle Spasms (muscle contraction): 2 people, 40.00%
  6. Itching: 2 people, 40.00%
  7. Infection: 2 people, 40.00%
  8. High Blood Pressure: 2 people, 40.00%
  9. Haemoglobin Decreased: 2 people, 40.00%
  10. Cancer Pain: 2 people, 40.00%

Other drugs people take *:

  1. Zoledronic Acid: 2 people, 40.00%
  2. Triamterene: 2 people, 40.00%
  3. Tramadol Hydrochloride: 2 people, 40.00%
  4. Selenium: 2 people, 40.00%
  5. Prednisolone: 2 people, 40.00%
  6. Morphine Sulfate: 2 people, 40.00%
  7. Metoclopramide: 2 people, 40.00%
  8. Inositol: 2 people, 40.00%
  9. Hydrochlorothiazide: 2 people, 40.00%
  10. Clarithromycin: 2 people, 40.00%

Other side effects people have besides Subdural empyema *:

  1. Infection: 4 people, 80.00%
  2. Periodontitis (inflammation of the tissue around the teeth): 3 people, 60.00%
  3. Brain Abscess: 3 people, 60.00%
  4. Headache (pain in head): 3 people, 60.00%
  5. Myositis (inflammation of the muscles): 3 people, 60.00%
  6. Nausea And Vomiting: 3 people, 60.00%
  7. Abscess (pus): 3 people, 60.00%
  8. Terminal State (the transitional states between life and biological death): 2 people, 40.00%
  9. Lymphadenopathy Mediastinal (an enlargement of the lymph nodes in the part of the chest that separates the lungs): 2 people, 40.00%
  10. Encephalitis (inflammation of the brain): 2 people, 40.00%

* Approximation only. Some reports may have incomplete information.

How to use the study?

You can discuss the study with your doctor, to ensure that all drug risks and benefits are fully discussed and understood.

Related studies

Drugs with ingredients of diclofenac sodium, their effectiveness, alternatives and more:

How the study uses the data?

The study uses data from the FDA. It is based on diclofenac sodium. All drugs that have the same active ingredients (e.g. brand name and generic drugs) are considered. Dosage of drugs is not considered in the study.

Who is eHealthMe?

With medical big data and proven AI algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 600+ medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).


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DISCLAIMER: All material available on is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

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