Dupuytren's contracture and drugs of ingredients of diltiazem hydrochloride - a phase IV clinical study of FDA data


Summary:

Dupuytren's contracture is found among people who take drugs with ingredients of diltiazem hydrochloride, especially for people who are male, 60+ old . This phase IV clinical study is created by eHealthMe based on reports of 113,616 people who have side effects when taking drugs with ingredients of diltiazem hydrochloride from the FDA, and is updated regularly.

Drug(s) considered in the study (i.e. both brand name and generic drugs): Cardizem, Cardizem cd, Cardizem la, Cardizem sr, Cartia xt, Dilacor xr, Dilt-cd, Diltiazem hydrochloride, Diltiazem hydrochloride in dextrose 5%, Diltzac, Taztia xt, Tiazac.

Phase IV trials are used to detect adverse drug outcomes and monitor drug effectiveness in the real world. With medical big data and AI algorithms, eHealthMe is running millions of phase IV trials and makes the results available to the public. Our original studies have been referenced on 600+ medical publications including The Lancet, Mayo Clinic Proceedings, and Nature.


On Sep, 25, 2022

113,616 people reported to have side effects when taking drugs with ingredients of diltiazem hydrochloride.
Among them, 9 people (0.01%) have Dupuytren's contracture


What is Dupuytren's contracture?

Dupuytren's contracture (thickening of the fibrous tissue layer underneath the skin of the palm and fingers) is found to be associated with 459 drugs and 212 conditions by eHealthMe.

Number of reports submitted per year:

Could drugs with ingredients of diltiazem hydrochloride cause Dupuytren's contracture?

Gender of people who have Dupuytren's contracture when taking drugs with ingredients of diltiazem hydrochloride *:

  • female: 22.22 %
  • male: 77.78 %

Age of people who have Dupuytren's contracture when taking drugs with ingredients of diltiazem hydrochloride *:

  • 0-1: 0.0 %
  • 2-9: 0.0 %
  • 10-19: 0.0 %
  • 20-29: 0.0 %
  • 30-39: 0.0 %
  • 40-49: 0.0 %
  • 50-59: 12.5 %
  • 60+: 87.5 %

Conditions people have *:

  1. Rash Pruritic (redness with itching): 3 people, 33.33%
  2. Ulcerative Colitis (inflammatory bowel disease (ibd). it causes swelling, ulcerations, and loss of function of the large intestine): 1 person, 11.11%
  3. Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 1 person, 11.11%
  4. Pain: 1 person, 11.11%
  5. Nasal Congestion (blockage of the nasal passages usually due to membranes lining the nose becoming swollen from inflamed blood vessels): 1 person, 11.11%
  6. Immunodeficiency Common Variable: 1 person, 11.11%
  7. Ill-Defined Disorder: 1 person, 11.11%
  8. Epilepsy (common and diverse set of chronic neurological disorders characterized by seizures): 1 person, 11.11%
  9. Diarrhea: 1 person, 11.11%

Other drugs people take *:

  1. Metoprolol Tartrate: 4 people, 44.44%
  2. Lasix: 4 people, 44.44%
  3. Keflex: 3 people, 33.33%
  4. Multihance: 3 people, 33.33%
  5. Mevacor: 3 people, 33.33%
  6. Magnevist: 3 people, 33.33%
  7. Lovastatin: 3 people, 33.33%
  8. Lopressor: 3 people, 33.33%
  9. Lisinopril: 3 people, 33.33%
  10. Lidex: 3 people, 33.33%

Other side effects people have besides Dupuytren's contracture *:

  1. Rashes (redness): 4 people, 44.44%
  2. Weakness: 3 people, 33.33%
  3. Depression: 3 people, 33.33%
  4. Fibrosis (formation of excess fibrous connective tissue in an organ or tissue): 3 people, 33.33%
  5. Ischaemic Ulcer (arterial ulcer): 3 people, 33.33%
  6. Joint Contracture (a permanent shortening of a muscle or joint): 3 people, 33.33%
  7. Joint Range Of Motion Decreased (disease of joint movement): 3 people, 33.33%
  8. Joint Swelling: 3 people, 33.33%
  9. Mental Disorder (a psychological term for a mental or behavioural pattern or anomaly that causes distress or disability): 3 people, 33.33%
  10. Mobility Decreased (ability to move is reduced): 3 people, 33.33%

* Approximation only. Some reports may have incomplete information.


How to use the study?

You can discuss the study with your doctor, to ensure that all drug risks and benefits are fully discussed and understood.

Related studies

Drugs with ingredients of diltiazem hydrochloride, their effectiveness, alternatives and more:

How the study uses the data?

The study uses data from the FDA. It is based on diltiazem hydrochloride. All drugs that have the same active ingredients (e.g. brand name and generic drugs) are considered. Dosage of drugs is not considered in the study.

Who is eHealthMe?

With medical big data and proven AI algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 600+ medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

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DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

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