Mania aggravated and drugs of ingredients of disulfiram - a phase IV clinical study of FDA data


Mania aggravated is found among people who take drugs with ingredients of disulfiram, especially for people who are female, 40-49 old . This phase IV clinical study is created by eHealthMe based on reports of 1,889 people who have side effects when taking drugs with ingredients of disulfiram from the FDA, and is updated regularly.

Drug(s) considered in the study (i.e. both brand name and generic drugs): Antabuse, Disulfiram.

Phase IV trials are used to detect adverse drug outcomes and monitor drug effectiveness in the real world. With medical big data and AI algorithms, eHealthMe is running millions of phase IV trials and makes the results available to the public. Our original studies have been referenced on 600+ medical publications including The Lancet, Mayo Clinic Proceedings, and Nature.

On Aug, 18, 2022

1,889 people reported to have side effects when taking drugs with ingredients of disulfiram.
Among them, 17 people (0.9%) have Mania aggravated

What is Mania aggravated?

Mania aggravated (worse irritable mood) is found to be associated with 579 drugs and 275 conditions by eHealthMe.

Number of reports submitted per year:

Could drugs with ingredients of disulfiram cause Mania aggravated?

Gender of people who have Mania aggravated when taking drugs with ingredients of disulfiram *:

  • female: 56.25 %
  • male: 43.75 %

Age of people who have Mania aggravated when taking drugs with ingredients of disulfiram *:

  • 0-1: 0.0 %
  • 2-9: 0.0 %
  • 10-19: 0.0 %
  • 20-29: 12.5 %
  • 30-39: 25.0 %
  • 40-49: 50.0 %
  • 50-59: 6.25 %
  • 60+: 6.25 %

Conditions people have *:

  1. Bipolar Disorder (mood disorder): 3 people, 17.65%
  2. Attention Deficit Hyperactivity Disorder (a chronic condition including attention difficulty, hyperactivity, and impulsiveness): 3 people, 17.65%
  3. Stress And Anxiety: 2 people, 11.76%
  4. Depression: 2 people, 11.76%
  5. Seizures (abnormal excessive or synchronous neuronal activity in the brain): 1 person, 5.88%
  6. Personality Disorder: 1 person, 5.88%
  7. Bipolar I Disorder (mood disorder that is characterized by at least one manic or mixed episode): 1 person, 5.88%

Other drugs people take *:

  1. Depakote: 4 people, 23.53%
  2. Prozac: 4 people, 23.53%
  3. Effexor: 3 people, 17.65%
  4. Seroquel: 3 people, 17.65%
  5. Zyprexa: 3 people, 17.65%
  6. Wellbutrin: 3 people, 17.65%
  7. Vivitrol: 2 people, 11.76%
  8. Hydrochlorothiazide: 2 people, 11.76%
  9. Aspirin: 2 people, 11.76%
  10. Ativan: 2 people, 11.76%

Other side effects people have besides Mania aggravated *:

  1. Insomnia (sleeplessness): 6 people, 35.29%
  2. Bipolar Disorder (mood disorder): 4 people, 23.53%
  3. Depression: 3 people, 17.65%
  4. Psychomotor Hyperactivity (feelings of extreme restlessness): 3 people, 17.65%
  5. Headache (pain in head): 2 people, 11.76%
  6. Hallucinations (sensations that appear real but are created by your mind): 2 people, 11.76%
  7. Dizziness: 2 people, 11.76%
  8. Disturbance In Attention: 2 people, 11.76%
  9. Delusion (a false belief or opinion): 2 people, 11.76%
  10. Memory Loss: 2 people, 11.76%

* Approximation only. Some reports may have incomplete information.

How to use the study?

You can discuss the study with your doctor, to ensure that all drug risks and benefits are fully discussed and understood.

Related studies

Drugs with ingredients of disulfiram, their effectiveness, alternatives and more:

How the study uses the data?

The study uses data from the FDA. It is based on disulfiram. All drugs that have the same active ingredients (e.g. brand name and generic drugs) are considered. Dosage of drugs is not considered in the study.

Who is eHealthMe?

With medical big data and proven AI algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 600+ medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).


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DISCLAIMER: All material available on is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

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