Dupuytren's contracture and drugs of ingredients of duloxetine hydrochloride - a phase IV clinical study of FDA data


Summary:

Dupuytren's contracture is found among people who take drugs with ingredients of duloxetine hydrochloride, especially for people who are female, 60+ old . This phase IV clinical study is created by eHealthMe based on reports of 172,444 people who have side effects when taking drugs with ingredients of duloxetine hydrochloride from the FDA, and is updated regularly.

Drug(s) considered in the study (i.e. both brand name and generic drugs): Cymbalta, Drizalma sprinkle, Duloxetine hydrochloride.

With medical big data and AI algorithms, eHealthMe enables everyone to run phase IV clinical trial to detect adverse drug outcomes and monitor effectiveness. Our original studies have been referenced on 600+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Most recently, phase IV clinial trails for COVID 19 vaccines have been added, check here.


On May, 22, 2022

172,444 people reported to have side effects when taking drugs with ingredients of duloxetine hydrochloride.
Among them, 8 people (0.0%) have Dupuytren's contracture


What is Dupuytren's contracture?

Dupuytren's contracture (thickening of the fibrous tissue layer underneath the skin of the palm and fingers) is found to be associated with 429 drugs and 186 conditions by eHealthMe.

Number of reports submitted per year:

Could drugs with ingredients of duloxetine hydrochloride cause Dupuytren's contracture?

Gender of people who have Dupuytren's contracture when taking drugs with ingredients of duloxetine hydrochloride *:

  • female: 87.5 %
  • male: 12.5 %

Age of people who have Dupuytren's contracture when taking drugs with ingredients of duloxetine hydrochloride *:

  • 0-1: 0.0 %
  • 2-9: 0.0 %
  • 10-19: 0.0 %
  • 20-29: 0.0 %
  • 30-39: 0.0 %
  • 40-49: 20 %
  • 50-59: 20 %
  • 60+: 60 %

Conditions people have *:

  1. Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 5 people, 62.50%
  2. Pain: 2 people, 25.00%
  3. Neuropathy Peripheral (surface nerve damage): 2 people, 25.00%
  4. Essential Tremor: 2 people, 25.00%
  5. Psoriatic Arthropathy (inflammation of the skin and joints with kin condition which typically causes patches (plaques) of red, scaly skin to develop): 1 person, 12.50%
  6. Neuralgia (pain in one or more nerves): 1 person, 12.50%
  7. Multiple Sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath): 1 person, 12.50%
  8. High Blood Pressure: 1 person, 12.50%
  9. High Blood Cholesterol: 1 person, 12.50%
  10. Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 1 person, 12.50%

Other drugs people take *:

  1. Humira: 5 people, 62.50%
  2. Oxycodone: 2 people, 25.00%
  3. Calcium: 2 people, 25.00%
  4. Magnesium: 2 people, 25.00%
  5. Vitamin D: 2 people, 25.00%
  6. Zolpidem: 1 person, 12.50%
  7. Enbrel: 1 person, 12.50%
  8. Aleve: 1 person, 12.50%
  9. Arava: 1 person, 12.50%
  10. Atenolol: 1 person, 12.50%

Other side effects people have besides Dupuytren's contracture *:

  1. Joint Pain: 2 people, 25.00%
  2. Peripheral Swelling: 2 people, 25.00%
  3. Tooth Abscess (pus formation in tooth): 2 people, 25.00%
  4. Oedema Peripheral (superficial swelling): 2 people, 25.00%
  5. Joint Swelling: 2 people, 25.00%
  6. Pain In Extremity: 2 people, 25.00%
  7. Paraesthesia (sensation of tingling, tickling, prickling, pricking, or burning of a person's skin with no apparent long-term physical effect): 2 people, 25.00%
  8. Musculoskeletal Stiffness (stiffness of the body's muscles, joints, tendons, ligaments and nerves): 2 people, 25.00%
  9. Eye Pain: 1 person, 12.50%
  10. Full Blood Count Abnormal: 1 person, 12.50%

* Approximation only. Some reports may have incomplete information.


How to use the study?

You can discuss the study with your doctor, to ensure that all drug risks and benefits are fully discussed and understood.

Related studies

Drugs with ingredients of duloxetine hydrochloride, their effectiveness, alternatives and more:

How the study uses the data?

The study uses data from the FDA. It is based on duloxetine hydrochloride. All drugs that have the same active ingredients (e.g. brand name and generic drugs) are considered. Dosage of drugs is not considered in the study.

Who is eHealthMe?

With medical big data and proven AI algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 600+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.

Recent studies on eHealthMe: