Sepsis and drugs of ingredients of duloxetine hydrochloride - a phase IV clinical study of FDA data


Summary:

Sepsis is found among people who take drugs with ingredients of duloxetine hydrochloride, especially for people who are female, 60+ old , have been taking the drugs for < 1 month. This phase IV clinical study is created by eHealthMe based on reports of 186,349 people who have side effects when taking drugs with ingredients of duloxetine hydrochloride from the FDA, and is updated regularly.

Drug(s) considered in the study (i.e. both brand name and generic drugs): Cymbalta, Drizalma sprinkle, Duloxetine hydrochloride.

Phase IV trials are used to detect adverse drug outcomes and monitor drug effectiveness in the real world. With medical big data and AI algorithms, eHealthMe is running millions of phase IV trials and makes the results available to the public. Our original studies have been referenced on 600+ medical publications including The Lancet, Mayo Clinic Proceedings, and Nature.


On Oct, 03, 2022

186,349 people reported to have side effects when taking drugs with ingredients of duloxetine hydrochloride.
Among them, 1,179 people (0.63%) have Sepsis


What is Sepsis?

Sepsis (a severe blood infection that can lead to organ failure and death) is found to be associated with 3,110 drugs and 3,178 conditions by eHealthMe.

Number of reports submitted per year:

Could drugs with ingredients of duloxetine hydrochloride cause Sepsis?

Time on drugs with ingredients of duloxetine hydrochloride when people have Sepsis *:

  • < 1 month: 43.86 %
  • 1 - 6 months: 24.56 %
  • 6 - 12 months: 5.26 %
  • 1 - 2 years: 12.28 %
  • 2 - 5 years: 5.26 %
  • 5 - 10 years: 7.02 %
  • 10+ years: 1.75 %

Gender of people who have Sepsis when taking drugs with ingredients of duloxetine hydrochloride *:

  • female: 65.74 %
  • male: 34.26 %

Age of people who have Sepsis when taking drugs with ingredients of duloxetine hydrochloride *:

  • 0-1: 0.34 %
  • 2-9: 0.0 %
  • 10-19: 0.23 %
  • 20-29: 1.82 %
  • 30-39: 4.77 %
  • 40-49: 13.96 %
  • 50-59: 26.56 %
  • 60+: 52.33 %

Conditions people have *:

  1. Pain: 144 people, 12.21%
  2. High Blood Pressure: 138 people, 11.70%
  3. Multiple Sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath): 121 people, 10.26%
  4. Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 108 people, 9.16%
  5. Multiple Myeloma (cancer of the plasma cells): 95 people, 8.06%
  6. Constipation: 67 people, 5.68%
  7. Insomnia (sleeplessness): 62 people, 5.26%
  8. Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 61 people, 5.17%
  9. Nausea (feeling of having an urge to vomit): 61 people, 5.17%
  10. High Blood Cholesterol: 57 people, 4.83%

Other drugs people take *:

  1. Lyrica: 169 people, 14.33%
  2. Lasix: 122 people, 10.35%
  3. Metformin: 110 people, 9.33%
  4. Ambien: 103 people, 8.74%
  5. Pantoprazole: 100 people, 8.48%
  6. Synthroid: 98 people, 8.31%
  7. Neurontin: 97 people, 8.23%
  8. Prilosec: 96 people, 8.14%
  9. Amlodipine: 95 people, 8.06%
  10. Nexium: 93 people, 7.89%

Other side effects people have besides Sepsis *:

  1. Pneumonia: 268 people, 22.73%
  2. Urinary Tract Infection: 262 people, 22.22%
  3. Pain: 173 people, 14.67%
  4. Fatigue (feeling of tiredness): 146 people, 12.38%
  5. Fall: 144 people, 12.21%
  6. Weakness: 139 people, 11.79%
  7. Hypotension (abnormally low blood pressure): 129 people, 10.94%
  8. Breathing Difficulty: 121 people, 10.26%
  9. Diarrhea: 119 people, 10.09%
  10. Nausea (feeling of having an urge to vomit): 117 people, 9.92%

* Approximation only. Some reports may have incomplete information.


How to use the study?

You can discuss the study with your doctor, to ensure that all drug risks and benefits are fully discussed and understood.

Related studies

Drugs with ingredients of duloxetine hydrochloride, their effectiveness, alternatives and more:

How the study uses the data?

The study uses data from the FDA. It is based on duloxetine hydrochloride. All drugs that have the same active ingredients (e.g. brand name and generic drugs) are considered. Dosage of drugs is not considered in the study.

Who is eHealthMe?

With medical big data and proven AI algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 600+ medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.

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