Drug dependence and drugs of ingredients of ethinyl estradiol; levonorgestrel - a phase IV clinical study of FDA data


Drug dependence is found among people who take drugs with ingredients of ethinyl estradiol; levonorgestrel, especially for people who are female, 30-39 old , have been taking the drugs for 5 - 10 years. This phase IV clinical study is created by eHealthMe based on reports of 19,378 people who have side effects when taking drugs with ingredients of ethinyl estradiol; levonorgestrel from the FDA, and is updated regularly.

Drug(s) considered in the study (i.e. both brand name and generic drugs): Afirmelle, Alesse, Altavera, Ashlyna, Aviane-21, Aviane-28, Ayuna, Balcoltra, Cerinta, Daysee, Dolishale, Elifemme, Enpresse-21, Enpresse-28, Ethinyl estradiol and levonorgestrel, Ethinyl estradiol; levonorgestrel, Falmina, Fayosim, Iclevia, Introvale, Jaimiess, Kurvelo, Lessina-21, Lessina-28, Levlite, Levonest, Levonorgestrel and ethinyl estradiol, Levonorgestrel and ethinyl estradiol and ethinyl estradiol, Levora 0.15/30-21, Levora 0.15/30-28, Lo simpesse, Loseasonique, Lybrel, Marlissa, Myzilra, Nordette-21, Nordette-28, Orsythia, Portia-21, Portia-28, Preven emergency contraceptive kit, Quartette, Quasense, Seasonale, Seasonique, Setlakin, Simpesse, Sylevia, Triphasil-21, Triphasil-28, Trivora-21, Trivora-28, Tyblume, Vienva.

Phase IV trials are used to detect adverse drug outcomes and monitor drug effectiveness in the real world. With medical big data and AI algorithms, eHealthMe is running millions of phase IV trials and makes the results available to the public. Our original studies have been referenced on 600+ medical publications including The Lancet, Mayo Clinic Proceedings, and Nature.

On May, 26, 2023

19,378 people reported to have side effects when taking drugs with ingredients of ethinyl estradiol; levonorgestrel.
Among them, 14 people (0.07%) have Drug dependence

What is Drug dependence?

Drug dependence is found to be associated with 1,857 drugs and 1,115 conditions by eHealthMe.

Number of reports submitted per year:

Could drugs with ingredients of ethinyl estradiol; levonorgestrel cause Drug dependence?

Time on drugs with ingredients of ethinyl estradiol; levonorgestrel when people have Drug dependence *:

  • < 1 month: 0.0 %
  • 1 - 6 months: 0.0 %
  • 6 - 12 months: 0.0 %
  • 1 - 2 years: 0.0 %
  • 2 - 5 years: 0.0 %
  • 5 - 10 years: 100 %
  • 10+ years: 0.0 %

Gender of people who have Drug dependence when taking drugs with ingredients of ethinyl estradiol; levonorgestrel *:

  • female: 100 %
  • male: 0.0 %

Age of people who have Drug dependence when taking drugs with ingredients of ethinyl estradiol; levonorgestrel *:

  • 0-1: 0.0 %
  • 2-9: 0.0 %
  • 10-19: 0.0 %
  • 20-29: 28.57 %
  • 30-39: 57.14 %
  • 40-49: 0.0 %
  • 50-59: 14.29 %
  • 60+: 0.0 %

Conditions people have *:

  1. Insomnia (sleeplessness): 4 people, 28.57%
  2. Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 3 people, 21.43%
  3. Cataplexy (loss of muscle tone accompanied by full conscious awareness): 2 people, 14.29%
  4. Withdrawal Syndrome (a discontinuation syndrome is a set of symptoms occurred due to discontinuation of substance): 1 person, 7.14%
  5. Stress And Anxiety: 1 person, 7.14%
  6. Speech Impairment (Adult) (inability to speak (adult)): 1 person, 7.14%
  7. Seasonal Allergy (allergic condition due to certain season): 1 person, 7.14%
  8. Pain: 1 person, 7.14%
  9. Ill-Defined Disorder: 1 person, 7.14%

Other drugs people take *:

  1. Xyrem: 7 people, 50.00%
  2. Adderall: 6 people, 42.86%
  3. Klonopin: 6 people, 42.86%
  4. Saccharomyces Boulardii: 4 people, 28.57%
  5. Sulfamethoxazole And Trimethoprim: 4 people, 28.57%
  6. Lamictal: 4 people, 28.57%
  7. Lidoderm: 4 people, 28.57%
  8. Lyrica: 4 people, 28.57%
  9. Inositol: 4 people, 28.57%
  10. Pepcid Ac: 4 people, 28.57%

Other side effects people have besides Drug dependence *:

  1. Nausea (feeling of having an urge to vomit): 7 people, 50.00%
  2. Drug Withdrawal Syndrome (interfere with normal social, occupational, or other functioning. are not due to another medical condition, drug use, or discontinuation): 5 people, 35.71%
  3. Drug Ineffective: 4 people, 28.57%
  4. Crying: 4 people, 28.57%
  5. Hepatomegaly (abnormal enlargement of the liver): 4 people, 28.57%
  6. Migraine (headache): 4 people, 28.57%
  7. Nausea And Vomiting: 4 people, 28.57%
  8. Pre-Existing Condition Improved: 4 people, 28.57%
  9. Infection In An Immunocompromised Host: 4 people, 28.57%
  10. Therapeutic Response Unexpected: 3 people, 21.43%

* Approximation only. Some reports may have incomplete information.

How to use the study?

You can discuss the study with your doctor, to ensure that all drug risks and benefits are fully discussed and understood.

Related studies

Drugs with ingredients of ethinyl estradiol; levonorgestrel, their effectiveness, alternatives and more:

How the study uses the data?

The study uses data from the FDA. It is based on ethinyl estradiol; levonorgestrel. All drugs that have the same active ingredients (e.g. brand name and generic drugs) are considered. Dosage of drugs is not considered in the study.

Who is eHealthMe?

With medical big data and proven AI algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 600+ medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).


WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

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