Ototoxicity and drugs of ingredients of gentamicin sulfate - a phase IV clinical study of FDA data


Summary:

Ototoxicity is found among people who take drugs with ingredients of gentamicin sulfate, especially for people who are female, 60+ old , have been taking the drugs for < 1 month. This phase IV clinical study is created by eHealthMe based on reports of 17,744 people who have side effects when taking drugs with ingredients of gentamicin sulfate from the FDA, and is updated regularly.

Drug(s) considered in the study (i.e. both brand name and generic drugs): Apogen, Bristagen, Garamycin, Genoptic, Gentacidin, Gentafair, Gentak, Gentamicin, Gentamicin sulfate, Gentamicin sulfate in sodium chloride 0.9% in plastic container, Isotonic gentamicin sulfate in plastic container, U-gencin.

With medical big data and AI algorithms, eHealthMe enables everyone to run phase IV clinical trial to detect adverse drug outcomes and monitor effectiveness. Our original studies have been referenced on 600+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Most recently, phase IV clinial trails for COVID 19 vaccines have been added, check here.


On Jun, 28, 2022

17,744 people reported to have side effects when taking drugs with ingredients of gentamicin sulfate.
Among them, 159 people (0.9%) have Ototoxicity


What is Ototoxicity?

Ototoxicity (damage to the ear) is found to be associated with 593 drugs and 325 conditions by eHealthMe.

Number of reports submitted per year:

Could drugs with ingredients of gentamicin sulfate cause Ototoxicity?

Time on drugs with ingredients of gentamicin sulfate when people have Ototoxicity *:

  • < 1 month: 77.27 %
  • 1 - 6 months: 15.91 %
  • 6 - 12 months: 0.0 %
  • 1 - 2 years: 4.55 %
  • 2 - 5 years: 2.27 %
  • 5 - 10 years: 0.0 %
  • 10+ years: 0.0 %

Gender of people who have Ototoxicity when taking drugs with ingredients of gentamicin sulfate *:

  • female: 55.47 %
  • male: 44.53 %

Age of people who have Ototoxicity when taking drugs with ingredients of gentamicin sulfate *:

  • 0-1: 0.0 %
  • 2-9: 2.33 %
  • 10-19: 3.1 %
  • 20-29: 2.33 %
  • 30-39: 6.2 %
  • 40-49: 12.4 %
  • 50-59: 26.36 %
  • 60+: 47.29 %

Conditions people have *:

  1. Peritonitis (inflammation of the peritoneum, the thin tissue that lines the inner wall of the abdomen and covers most of the abdominal organs): 11 people, 6.92%
  2. Endocarditis (inflammation in heart muscle): 7 people, 4.40%
  3. Osteomyelitis (infection of bone): 6 people, 3.77%
  4. Sepsis (a severe blood infection that can lead to organ failure and death): 4 people, 2.52%
  5. Rhodococcus Infection: 3 people, 1.89%
  6. Cervix Carcinoma (cancer of cervix): 3 people, 1.89%
  7. Device Related Infection: 3 people, 1.89%
  8. Brain Abscess: 3 people, 1.89%
  9. Pseudomonas Infection (pseudomonas infection is caused by a bacterium, pseudomonas aeruginosa): 3 people, 1.89%
  10. Cystic Fibrosis (disease of the secretary glands): 2 people, 1.26%

Other drugs people take *:

  1. Vancomycin: 22 people, 13.84%
  2. Furosemide: 5 people, 3.14%
  3. Taxol: 5 people, 3.14%
  4. Ceftazidime: 4 people, 2.52%
  5. Omeprazole: 3 people, 1.89%
  6. Metoclopramide Hydrochloride: 3 people, 1.89%
  7. Clopidogrel: 3 people, 1.89%
  8. Levothyroxine Sodium: 3 people, 1.89%
  9. Olanzapine: 3 people, 1.89%
  10. Cipro: 3 people, 1.89%

Other side effects people have besides Ototoxicity *:

  1. Dizziness: 26 people, 16.35%
  2. Vestibular Disorder (disorders of the body's balance (vestibular) system in the inner ear): 22 people, 13.84%
  3. Deafness Neurosensory: 21 people, 13.21%
  4. Tinnitus (a ringing in the ears): 18 people, 11.32%
  5. Balance Disorder: 18 people, 11.32%
  6. Nausea (feeling of having an urge to vomit): 14 people, 8.81%
  7. Hearing Loss: 12 people, 7.55%
  8. Vision Blurred: 12 people, 7.55%
  9. Fall: 10 people, 6.29%
  10. Hearing Impaired: 9 people, 5.66%

* Approximation only. Some reports may have incomplete information.


How to use the study?

You can discuss the study with your doctor, to ensure that all drug risks and benefits are fully discussed and understood.

How the study uses the data?

The study uses data from the FDA. It is based on gentamicin sulfate. All drugs that have the same active ingredients (e.g. brand name and generic drugs) are considered. Dosage of drugs is not considered in the study.

Who is eHealthMe?

With medical big data and proven AI algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 600+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

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